(Q38106011)

28 August 2017

Molecular players in neutrophil chemotaxis--focus on PI3K and small GTPases (English)

1 reference

28 August 2017

1 reference

Sonja Vermeren

2

0 references

author name string

Laure Gambardella

series ordinal

1

1 reference

28 August 2017

10 May 2013

1 reference

Journal of Leukocyte Biology

28 August 2017

1 reference

28 August 2017

94

1 reference

28 August 2017

4

1 reference

28 August 2017

603-612

1 reference

Neutrophils and immunity: challenges and opportunities

28 August 2017

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Getting to the site of inflammation: the leukocyte adhesion cascade updated

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Receptors induce chemotaxis by releasing the betagamma subunit of Gi, not by activating Gq or Gs

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Polarization of chemoattractant receptor signaling during neutrophil chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Mechanisms of force generation and force transmission during interstitial leukocyte migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

21 January 2018

Life at the leading edge

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Cell mechanics and the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Cellular responses to extracellular guidance cues

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Collective cell migration in morphogenesis, regeneration and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Importance of integrin LFA-1 deactivation for the generation of immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Rapid leukocyte migration by integrin-independent flowing and squeezing

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Random locomotion and chemotaxis of human blood polymorphonuclear leukocytes (PMN) in the presence of EDTA: PMN in close quarters require neither leukocyte integrins nor external divalent cations

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Rapid recruitment of inflammatory monocytes is independent of neutrophil migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Transendothelial migration and trafficking of leukocytes in LFA-1-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Ability of polymorphonuclear leukocytes to orient in gradients of chemotactic factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

A novel optical assay system for the quantitative measurement of chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Microfluidic technologies for temporal perturbations of chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

A transgenic zebrafish model of neutrophilic inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Neutrophil chemotaxis within a competing gradient of chemoattractants

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

A unique requirement for the leukotriene B4 receptor BLT1 for neutrophil recruitment in inflammatory arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Neutrophils lacking phosphoinositide 3-kinase gamma show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Mechanisms and implications of phosphoinositide 3-kinase delta in promoting neutrophil trafficking into inflamed tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

PI(3)Kγ has an important context-dependent role in neutrophil chemokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

PI3-kinase signaling contributes to orientation in shallow gradients and enhances speed in steep chemoattractant gradients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Regulation of PTEN by Rho small GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Myeloid-specific deletion of tumor suppressor PTEN augments neutrophil transendothelial migration during inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Phosphoinositide lipid phosphatase SHIP1 and PTEN coordinate to regulate cell migration and adhesion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Involvement of SHIP in TLR2-induced neutrophil activation and acute lung injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

The SH2-domain-containing inositol 5-phosphatase (SHIP) limits the motility of neutrophils and their recruitment to wounds in zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Rho GTPases in cell biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

GBF1 bears a novel phosphatidylinositol-phosphate binding module, BP3K, to link PI3Kγ activity with Arf1 activation involved in GPCR-mediated neutrophil chemotaxis and superoxide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Cytohesin-1 regulates human blood neutrophil adhesion to endothelial cells through β2 integrin activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

P-Rex1 regulates neutrophil function

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Vav GEFs are required for beta2 integrin-dependent functions of neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

The hemopoietic Rho/Rac guanine nucleotide exchange factor Vav1 regulates N-formyl-methionyl-leucyl-phenylalanine-activated neutrophil functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Vav1 is essential for mechanotactic crawling and migration of neutrophils out of the inflamed microvasculature

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Spatiotemporal dynamics of RhoA activity in migrating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Coordination of Rho GTPase activities during cell protrusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Multiple roles for RhoA during T cell transendothelial migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Neutrophil polarization: spatiotemporal dynamics of RhoA activity support a self-organizing mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Integrin-induced PIP5K1C kinase polarization regulates neutrophil polarization, directionality, and in vivo infiltration

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Activation of Rhoa and ROCK are essential for detachment of migrating leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

RhoA is required for monocyte tail retraction during transendothelial migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

The mDial formin is required for neutrophil polarization, migration, and activation of the LARG/RhoA/ROCK signaling axis during chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Phosphoinositide 3-OH kinase regulates integrin-dependent processes in neutrophils by signaling through its effector ARAP3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Neutrophil functions and autoimmune arthritis in the absence of p190RhoGAP: generation and analysis of a novel null mutation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Galpha13 stimulates cell migration through cortactin-interacting protein Hax-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Hax1 regulates neutrophil adhesion and motility through RhoA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

A comparison of mathematical models for polarization of single eukaryotic cells in response to guided cues

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

How cells integrate complex stimuli: the effect of feedback from phosphoinositides and cell shape on cell polarization and motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

A local coupling model and compass parameter for eukaryotic chemotaxis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Chemotaxis: a feedback-based computational model robustly predicts multiple aspects of real cell behaviour

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Network crosstalk dynamically changes during neutrophil polarization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

Chemotaxis in the Absence of PIP3 Gradients

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

ARAP3 is a PI3K- and rap-regulated GAP for RhoA

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.1112564

21 January 2018

Identifiers

DOI

10.1189/JLB.1112564

1 reference

28 August 2017

1 reference

PubMed ID

23667166