(Q38108123)

29 August 2017

title

Post-traumatic osteoarthritis: from mouse models to clinical trials (English)

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29 August 2017

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2

David J Hunter

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29 August 2017

Christopher B Little

1

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29 August 2017

language of work or name

English

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publication date

21 May 2013

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Nature Reviews Rheumatology

29 August 2017

published in

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29 August 2017

volume

9

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29 August 2017

issue

8

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29 August 2017

page(s)

485-497

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https://scigraph.springernature.com/pub.10.1038/nrrheum.2013.72

29 August 2017

exact match

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

31 March 2020

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ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization

31 March 2020

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Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor

31 March 2020

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Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis

31 March 2020

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Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair

31 March 2020

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Identification of a central role for complement in osteoarthritis

31 March 2020

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Mice over-expressing salmon calcitonin have strongly attenuated osteoarthritic histopathological changes after destabilization of the medial meniscus

31 March 2020

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Treatment with calcitonin suppresses the responses of bone, cartilage, and synovium in the early stages of canine experimental osteoarthritis and significantly reduces the severity of the cartilage lesions

31 March 2020

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Oral salmon calcitonin reduces cartilage and bone pathology in an osteoarthritis rat model with increased subchondral bone turnover.

31 March 2020

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Treatment with calcitonin prevents the net loss of collagen, hyaluronan and proteoglycan aggregates from cartilage in the early stages of canine experimental osteoarthritis

31 March 2020

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T helper cells promote disease progression of osteoarthritis by inducing macrophage inflammatory protein-1γ

31 March 2020

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C/EBPbeta Promotes transition from proliferation to hypertrophic differentiation of chondrocytes through transactivation of p57.

31 March 2020

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Osteoarthritic change is delayed in a Ctsk-knockout mouse model of osteoarthritis

31 March 2020

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Protective effects of a cathepsin K inhibitor, SB-553484, in the canine partial medial meniscectomy model of osteoarthritis.

31 March 2020

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Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis

31 March 2020

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Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice

31 March 2020

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Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development.

31 March 2020

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Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction

31 March 2020

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Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction

31 March 2020

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In vivo bone-specific EphB4 overexpression in mice protects both subchondral bone and cartilage during osteoarthritis.

31 March 2020

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Proteinase-activated receptor-2 gene disruption limits the effect of osteoarthritis on cartilage in mice: a novel target in joint degradation

31 March 2020

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Protease-activated receptor 2: a novel pathogenic pathway in a murine model of osteoarthritis

31 March 2020

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Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice

31 March 2020

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In vivo osteoarthritis target validation utilizing genetically-modified mice

31 March 2020

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Chondroprotective effect of intraarticular injections of interleukin-1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase-1 expression

31 March 2020

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Osteoprotegerin inhibits cartilage degradation through an effect on trabecular bone in murine experimental osteoarthritis

31 March 2020

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Interleukin-6 plays an essential role in hypoxia-inducible factor 2α-induced experimental osteoarthritic cartilage destruction in mice

31 March 2020

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Enhanced cartilage regeneration in MIA/CD-RAP deficient mice

31 March 2020

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Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.

31 March 2020

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Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects

31 March 2020

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Cartilage degradation biomarkers predict efficacy of a novel, highly selective matrix metalloproteinase 13 inhibitor in a dog model of osteoarthritis: confirmation by multivariate analysis that modulation of type II collagen and aggrecan degradation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.72

MMP13 is a critical target gene during the progression of osteoarthritis.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.72

Absence of posttraumatic arthritis following intraarticular fracture in the MRL/MpJ mouse

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.72

Proteoglycan 4 expression protects against the development of osteoarthritis

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.72

Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin

31 March 2020

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Prevention of cartilage degeneration and restoration of chondroprotection by lubricin tribosupplementation in the rat following anterior cruciate ligament transection.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.72

Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development

31 March 2020

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Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability.

31 March 2020

1 reference

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Inhibition of bone resorption blunts osteoarthritis in mice with high bone remodelling.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.72

Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.72

Modulating hedgehog signaling can attenuate the severity of osteoarthritis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.72

Transglutaminase-2 differently regulates cartilage destruction and osteophyte formation in a surgical model of osteoarthritis

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.72

Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.72

Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament

31 March 2020

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Pralnacasan, an inhibitor of interleukin-1beta converting enzyme, reduces joint damage in two murine models of osteoarthritis

31 March 2020

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Cytokine-like 1 knock-out mice (Cytl1-/-) show normal cartilage and bone development but exhibit augmented osteoarthritic cartilage destruction

31 March 2020

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Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis

31 March 2020

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The therapeutic effects of basic fibroblast growth factor contained in gelatin hydrogel microspheres on experimental osteoarthritis in the rabbit knee.

31 March 2020

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Genetic deletion of low-density lipoprotein receptor-related protein 5 increases cartilage degradation in instability-induced osteoarthritis.

31 March 2020

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MicroRNA-140 plays dual roles in both cartilage development and homeostasis

31 March 2020

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Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase

31 March 2020

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Accelerated development of aging-associated and instability-induced osteoarthritis in osteopontin-deficient mice

31 March 2020

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Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.72

Deficiency of tenascin-C delays articular cartilage repair in mice

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.72

TIMP2 deficient mice develop accelerated osteoarthritis via promotion of angiogenesis upon destabilization of the medial meniscus

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.72

Prevention of cartilage destruction with intraarticular osteoclastogenesis inhibitory factor/osteoprotegerin in a murine model of osteoarthritis

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.72

Interruption of glycosphingolipid synthesis enhances osteoarthritis development in mice

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.72

IL-17RA aptamer-mediated repression of IL-6 inhibits synovium inflammation in a murine model of osteoarthritis

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.72

Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.72

Intra-articular delivery of purified mesenchymal stem cells from C57BL/6 or MRL/MpJ superhealer mice prevents posttraumatic arthritis

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.72

Autophagy activation by rapamycin reduces severity of experimental osteoarthritis.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.72

MicroRNA-181b regulates articular chondrocytes differentiation and cartilage integrity.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.72

Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.72

Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.72

Procyanidin B3 prevents articular cartilage degeneration and heterotopic cartilage formation in a mouse surgical osteoarthritis model

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.72

A novel disease-modifying osteoarthritis drug candidate targeting Runx1

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2013.72

Articular fractures: does an anatomic reduction really change the result?

31 March 2020

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12 December 2020

Epidemiology of Acute Knee Injuries: A Prospective Hospital Investigation

1 reference

12 December 2020

Long-term results after primary repair or non-surgical treatment of anterior cruciate ligament rupture: a randomized study with a 15-year follow-up

1 reference

12 December 2020

Arthritis prevalence and activity limitations--United States, 1990

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12 December 2020

Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association

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12 December 2020

The pathomechanical etiology of post-traumatic osteoarthritis following intraarticular fractures

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12 December 2020

Anterior cruciate ligament tears: conservative or surgical treatment? A critical review of the literature

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12 December 2020

Acute rotational trauma to the knee: poor agreement between clinical assessment and magnetic resonance imaging findings

1 reference

12 December 2020

Towards a national sports safety strategy: addressing facilitators and barriers towards safety guideline uptake

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12 December 2020

Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors

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12 December 2020

Identifiers

DOI

10.1038/NRRHEUM.2013.72

1 reference

Dimensions Publication ID

29 August 2017

1005163041

0 references

1 reference