(Q38110358)

29 August 2017

title

On 'polypharmacy' and multi-target agents, complementary strategies for improving the treatment of depression: a comparative appraisal (English)

1 reference

29 August 2017

Mark J Millan

1

1 reference

29 August 2017

publication date

30 May 2013

1 reference

The International Journal of Neuropsychopharmacology

29 August 2017

published in

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29 August 2017

volume

17

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29 August 2017

issue

7

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29 August 2017

page(s)

1009-1037

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NPY intraperitoneal injections produce antidepressant-like effects and downregulate BDNF in the rat hypothalamus

29 August 2017

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Genetic and epigenetic defects in mental retardation.

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Efficacy of the novel antidepressant agomelatine on the circadian rest-activity cycle and depressive and anxiety symptoms in patients with major depressive disorder: a randomized, double-blind comparison with sertraline

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Celecoxib enhances the effect of reboxetine and fluoxetine on cortical noradrenaline and serotonin output in the rat.

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The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder

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Serum ghrelin levels and the effects of antidepressants in major depressive disorder and panic disorder

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Infusion of neuropeptide Y into CA3 region of hippocampus produces antidepressant-like effect via Y1 receptor

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The mGlu5 receptor antagonist MPEP activates specific stress-related brain regions and lacks neurotoxic effects of the NMDA receptor antagonist MK-801: significance for the use as anxiolytic/antidepressant drug

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Sleep deprivation in depression

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Current perspectives on selective dopamine D(3) receptor antagonists as pharmacotherapeutics for addictions and related disorders

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Chronic treatment with celecoxib reverses chronic unpredictable stress-induced depressive-like behavior via reducing cyclooxygenase-2 expression in rat brain

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Efficacy of the sequential integration of psychotherapy and pharmacotherapy in major depressive disorder: a preliminary meta-analysis

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Epigenetic dysregulation in cognitive disorders.

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Cholinergic receptor subtypes and their role in cognition, emotion, and vigilance control: an overview of preclinical and clinical findings

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Antidepressant-like effect induced by systemic and intra-hippocampal administration of DNA methylation inhibitors.

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The hidden third: improving outcome in treatment-resistant depression

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Glucocorticoid antagonists in neuropsychiatric [corrected] disorders

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Transcranial direct current stimulation for the outpatient treatment of poor-responder depressed patients.

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Aberrant epigenetic landscape in intellectual disability.

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S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models

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Addition of the alpha2-antagonist yohimbine to fluoxetine: effects on rate of antidepressant response

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Combining medications to enhance depression outcomes (CO-MED): acute and long-term outcomes of a single-blind randomized study.

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Agomelatine, the first melatonergic antidepressant: discovery, characterization and development

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Combination of antidepressants in the treatment of major depressive disorder: a systematic review and meta-analysis

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Polypharmacy in schizophrenia

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Escitalopram, an antidepressant with an allosteric effect at the serotonin transporter--a review of current understanding of its mechanism of action

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Antidepressant-like effect of sodium butyrate (HDAC inhibitor) and its molecular mechanism of action in the rat hippocampus

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Characterization of the potent 5-HT(1A/B) receptor antagonist and serotonin reuptake inhibitor SB-649915: preclinical evidence for hastened onset of antidepressant/anxiolytic efficacy.

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Selective blockade of dopamine D3 receptors enhances while D2 receptor antagonism impairs social novelty discrimination and novel object recognition in rats: a key role for the prefrontal cortex.

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Neurokinin1 antagonists potentiate antidepressant properties of serotonin reuptake inhibitors, yet blunt their anxiogenic actions: a neurochemical, electrophysiological, and behavioral characterization

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Buspirone modulates basal and fluoxetine-stimulated dialysate levels of dopamine, noradrenaline and serotonin in the frontal cortex of freely moving rats: activation of serotonin1A receptors and blockade of alpha2-adrenergic receptors underlie its a

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Polypharmacy prevalence rates in the treatment of unipolar depression in an outpatient clinic

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Tricyclic antidepressant pharmacology and therapeutic drug interactions updated

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The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress

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Serotonin receptors, type 4: a new hope?

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7 January 2021

Reboxetine combination in treatment-resistant depression to selective serotonin reuptake inhibitors.

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7 January 2021

Epigenetic treatments for cognitive impairments

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5-HT1 receptor augmentation strategies as enhanced efficacy: therapeutics for psychiatric disorders

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Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans

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Trace amine-associated receptor 1 partial agonism reveals novel paradigm for neuropsychiatric therapeutics.

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Efficacy of light therapy for perinatal depression: a review

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The efficacy profile of vilazodone, a novel antidepressant for the treatment of major depressive disorder

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Results from 2 randomized, double-blind, placebo-controlled studies of the novel NK1 receptor antagonist casopitant in patients with major depressive disorder

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Augmentation of SSRI effects on serotonin by 5-HT2C antagonists: mechanistic studies.

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7 January 2021

Mode of action of agomelatine: synergy between melatonergic and 5-HT2C receptors.

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From synapse to nucleus: novel targets for treating depression

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5-HT2 ligands in the treatment of anxiety and depression

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Antidepressant actions of histone deacetylase inhibitors

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Tachykinin receptor antagonists in clinical trials

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https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Potential antidepressants displayed combined alpha(2)-adrenoceptor antagonist and monoamine uptake inhibitor properties

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Potentially inappropriate use of psychotropic medications in hospitalized elderly patients in France: cross-sectional analysis of the prospective, multicentre SAFEs cohort

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

From single- to multi-target drugs in cancer therapy: when aspecificity becomes an advantage.

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Genes, environment, and individual differences in responding to treatment for depression

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Medication augmentation after the failure of SSRIs for depression.

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Efficacy and tolerability of the novel triple reuptake inhibitor amitifadine in the treatment of patients with major depressive disorder: a randomized, double-blind, placebo-controlled trial

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

A conformational restriction approach to the development of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

The central and basolateral amygdala are critical sites of neuropeptide Y/Y2 receptor-mediated regulation of anxiety and depression.

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Emerging drugs for major depressive disorder

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Exploration of structure-activity relationships for dual serotonin transporter reuptake inhibitors-histamine H3 receptor antagonists

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

If at first you don't succeed: a review of the evidence for antidepressant augmentation, combination and switching strategies

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Agomelatine prevents relapse in generalized anxiety disorder: a 6-month randomized, double-blind, placebo-controlled discontinuation study

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Can we discover pharmacological promiscuity early in the drug discovery process?

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

MCL0042: a nonpeptidic MC4 receptor antagonist and serotonin reuptake inhibitor with anxiolytic- and antidepressant-like activity

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Systems genetics for drug target discovery

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Melanocortin-4 receptor antagonists for the treatment of depression and anxiety disorders

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Emerging targets for the pharmacological treatment of depression: focus on melatonergic system

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Activation of the mGlu7 receptor elicits antidepressant-like effects in mice

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Discovery of Lu AA33810: a highly selective and potent NPY5 antagonist with in vivo efficacy in a model of mood disorder

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Acute ghrelin administration reverses depressive-like behavior induced by bilateral olfactory bulbectomy in mice

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

ECNP Summit on the future of CNS drug research in Europe 2011: report prepared for ECNP by David Nutt and Guy Goodwin.

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Metabotropic glutamate receptors: from the workbench to the bedside

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Blockade of the high-affinity noradrenaline transporter (NET) by the selective 5-HT reuptake inhibitor escitalopram: an in vivo microdialysis study in mice

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Immune system to brain signaling: neuropsychopharmacological implications.

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Characterization of an mGluR2/3 negative allosteric modulator in rodent models of depression

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Celecoxib treatment in an early stage of schizophrenia: results of a randomized, double-blind, placebo-controlled trial of celecoxib augmentation of amisulpride treatment

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Recent developments in the design of anti-depressive therapies: targeting the serotonin transporter

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Circadian abnormalities, molecular clock genes and chronobiological treatments in depression

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Rapid-acting antidepressant strategies: mechanisms of action

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

MicroRNAs and depression

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Selective p38α MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Fragments, network biology and designing multiple ligands

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

The physicochemical challenges of designing multiple ligands

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol-2(3H)-one]: a novel dopamine D2 receptor partial agonist/serotonin reuptake inhibitor with preclinical antipsychotic-like and antidepressant-like activity

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Pharmacological effects of Lu AA21004: a novel multimodal compound for the treatment of major depressive disorder.

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

NIMH initiatives to facilitate collaborations among industry, academia, and government for the discovery and clinical testing of novel models and drugs for psychiatric disorders

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Acceleration and augmentation of antidepressants with lithium for depressive disorders: two meta-analyses of randomized, placebo-controlled trials.

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Which antidepressants have demonstrated superior efficacy? A review of the evidence

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Intra-lateral septal infusions of folic acid alone or combined with various antidepressant drugs produce antidepressant-like actions in male Wistar rats forced to swim

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

The mGluR7 allosteric agonist AMN082 produces antidepressant-like effects by modulating glutamatergic signaling

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

Randomized comparison of selective serotonin reuptake inhibitor (escitalopram) monotherapy and antidepressant combination pharmacotherapy for major depressive disorder with melancholic features: a CO-MED report.

1 reference

https://api.crossref.org/works/10.1017%2FS1461145712001496

7 January 2021

10.1017/S1461145712001496

Identifiers

DOI

1 reference

29 August 2017

1 reference