(Q38111801)

29 August 2017

title

Contributions of co-chaperones and post-translational modifications towards Hsp90 drug sensitivity (English)

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29 August 2017

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5

Len Neckers

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29 August 2017

4

Jane B Trepel

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29 August 2017

author name string

Annerleim Walton-Diaz

1

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29 August 2017

Sahar Khan

2

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29 August 2017

Dimitra Bourboulia

3

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29 August 2017

Mehdi Mollapour

6

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29 August 2017

publication date

1 June 2013

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Future Medicinal Chemistry

29 August 2017

published in

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29 August 2017

volume

5

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29 August 2017

issue

9

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29 August 2017

page(s)

1059-1071

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Hsp90 molecular chaperone inhibitors: are we there yet?

29 August 2017

cites work

1 reference

Structure and functional relationships of Hsp90.

21 January 2018

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Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

21 January 2018

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Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

21 January 2018

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The cellular world according to Hsp90.

21 January 2018

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The Hsp90 chaperone machinery: conformational dynamics and regulation by co-chaperones

21 January 2018

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Post-translational modifications of Hsp90 and their contributions to chaperone regulation

21 January 2018

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Evolution and function of diverse Hsp90 homologs and cochaperone proteins

21 January 2018

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Targeting the dynamic HSP90 complex in cancer

21 January 2018

1 reference

HSP90 and the chaperoning of cancer

21 January 2018

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The molecular chaperone Hsp90α is required for meiotic progression of spermatocytes beyond pachytene in the mouse

21 January 2018

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HSP90 at the hub of protein homeostasis: emerging mechanistic insights

21 January 2018

1 reference

Heat-shock protein 90, a chaperone for folding and regulation

21 January 2018

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Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex

21 January 2018

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Structures of GRP94-nucleotide complexes reveal mechanistic differences between the hsp90 chaperones

21 January 2018

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Spatially and kinetically resolved changes in the conformational dynamics of the Hsp90 chaperone machine

21 January 2018

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Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90.

21 January 2018

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The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis

21 January 2018

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The complex dance of the molecular chaperone Hsp90.

21 January 2018

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Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements

21 January 2018

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Structure of an Hsp90-Cdc37-Cdk4 complex.

21 January 2018

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Hsp90: structure and function

21 January 2018

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Structure and mechanism of the Hsp90 molecular chaperone machinery

21 January 2018

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HSP90 as a platform for the assembly of more effective cancer chemotherapy

21 January 2018

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Tumor-intrinsic and tumor-extrinsic factors impacting hsp90- targeted therapy

21 January 2018

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HSP90 inhibition is effective in breast cancer: a phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab.

21 January 2018

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Inhibition of heat shock protein 90 (HSP90) as a therapeutic strategy for the treatment of myeloma and other cancers

21 January 2018

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The Hsp90 inhibitor IPI-504 overcomes bortezomib resistance in mantle cell lymphoma in vitro and in vivo by down-regulation of the prosurvival ER chaperone BiP/Grp78

21 January 2018

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Antitumor activity of the Hsp90 inhibitor IPI-504 in HER2-positive trastuzumab-resistant breast cancer

21 January 2018

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Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

21 January 2018

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Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol

21 January 2018

1 reference

NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models

21 January 2018

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89Zr-bevacizumab PET of early antiangiogenic tumor response to treatment with HSP90 inhibitor NVP-AUY922.

21 January 2018

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Anti-tumor activity against multiple myeloma by combination of KW-2478, an Hsp90 inhibitor, with bortezomib

21 January 2018

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Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design

21 January 2018

1 reference

A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

21 January 2018

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Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms

21 January 2018

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Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

21 January 2018

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The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors

21 January 2018

1 reference

NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis

21 January 2018

1 reference

New molecular and biological mechanism of antitumor activities of KW-2478, a novel nonansamycin heat shock protein 90 inhibitor, in multiple myeloma cells.

21 January 2018

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The novel HSP90 inhibitor STA-1474 exhibits biologic activity against osteosarcoma cell lines

21 January 2018

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The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

21 January 2018

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Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket

21 January 2018

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Modulation of Hsf1 activity by novobiocin and geldanamycin.

21 January 2018

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A systematic protocol for the characterization of Hsp90 modulators.

21 January 2018

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KU135, a novel novobiocin-derived C-terminal inhibitor of the 90-kDa heat shock protein, exerts potent antiproliferative effects in human leukemic cells

21 January 2018

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21 January 2018

What is a co-chaperone?

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The Hsp90 co-chaperones Cdc37 and Sti1 interact physically and genetically

21 January 2018

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In vivo analysis of the Hsp90 cochaperone Sti1 (p60)

21 January 2018

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Sti1 is a non-competitive inhibitor of the Hsp90 ATPase. Binding prevents the N-terminal dimerization reaction during the atpase cycle

21 January 2018

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Independent regulation of Hsp70 and Hsp90 chaperones by Hsp70/Hsp90-organizing protein Sti1 (Hop1).

21 January 2018

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Sti1 and Cdc37 can stabilize Hsp90 in chaperone complexes with a protein kinase

21 January 2018

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Cdc37 goes beyond Hsp90 and kinases

21 January 2018

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Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37.

21 January 2018

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Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37.

21 January 2018

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The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins

21 January 2018

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Intracellular dynamics of the Hsp90 co-chaperone p23 is dictated by Hsp90.

21 January 2018

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The influence of ATP and p23 on the conformation of hsp90.

21 January 2018

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Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone

21 January 2018

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Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery

21 January 2018

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Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1

21 January 2018

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Nucleotide-dependent interaction of Saccharomyces cerevisiae Hsp90 with the cochaperone proteins Sti1, Cpr6, and Sba1.

21 January 2018

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Cpr6 and Cpr7, two closely related Hsp90-associated immunophilins from Saccharomyces cerevisiae, differ in their functional properties

21 January 2018

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Sgt1p is a unique co-chaperone that acts as a client adaptor to link Hsp90 to Skp1p

21 January 2018

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Molecular chaperones and protein kinase quality control.

21 January 2018

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Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes

21 January 2018

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The Hsp90/Cdc37p chaperone system is a determinant of molybdate resistance in Saccharomyces cerevisiae

21 January 2018

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A common conformationally coupled ATPase mechanism for yeast and human cytoplasmic HSP90s

21 January 2018

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p23/Sba1p protects against Hsp90 inhibitors independently of its intrinsic chaperone activity

21 January 2018

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Plasticity of the Hsp90 chaperone machine in divergent eukaryotic organisms

21 January 2018

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The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)

21 January 2018

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Co-chaperone regulation of conformational switching in the Hsp90 ATPase cycle

21 January 2018

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Targeting Cdc37 inhibits multiple signaling pathways and induces growth arrest in prostate cancer cells

21 January 2018

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Silencing the cochaperone CDC37 destabilizes kinase clients and sensitizes cancer cells to HSP90 inhibitors

21 January 2018

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Characterization of celastrol to inhibit hsp90 and cdc37 interaction

21 January 2018

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A positive feedback loop between protein kinase CKII and Cdc37 promotes the activity of multiple protein kinases

21 January 2018

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Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery

21 January 2018

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Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37.

21 January 2018

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Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine

21 January 2018

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Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis

21 January 2018

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Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin

21 January 2018

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The Co-chaperone Sba1 connects the ATPase reaction of Hsp90 to the progression of the chaperone cycle

21 January 2018

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Heat shock protein 90: a unique chemotherapeutic target

21 January 2018

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Structural studies on the co-chaperone Hop and its complexes with Hsp90.

21 January 2018

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The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop

21 January 2018

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Mixed Hsp90-cochaperone complexes are important for the progression of the reaction cycle

21 January 2018

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Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90beta, a property that can be exploited in screens for new Hsp90 chaperone inhibitors

21 January 2018

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hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures

21 January 2018

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Chaperone ligand-discrimination by the TPR-domain protein Tah1.

21 January 2018

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Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones

21 January 2018

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Chaperoning the chaperone: a role for the co-chaperone Cpr7 in modulating Hsp90 function in Saccharomyces cerevisiae.

21 January 2018

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Integration of the accelerator Aha1 in the Hsp90 co-chaperone cycle

21 January 2018

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CNS1 encodes an essential p60/Sti1 homolog in Saccharomyces cerevisiae that suppresses cyclophilin 40 mutations and interacts with Hsp90.

21 January 2018

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Hsp90 chaperone complexes are required for the activity and stability of yeast protein kinases Mik1, Wee1 and Swe1.

21 January 2018

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Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function

21 January 2018

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Combined inhibition of Wee1 and Hsp90 activates intrinsic apoptosis in cancer cells

21 January 2018

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Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion

21 January 2018

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HDAC6 inhibition enhances 17-AAG--mediated abrogation of hsp90 chaperone function in human leukemia cells

21 January 2018

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Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity

21 January 2018

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Possible role for serine/threonine phosphorylation in the regulation of the heteroprotein complex between the hsp90 stress protein and the pp60v-src tyrosine kinase

21 January 2018

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The phosphatase Ppt1 is a dedicated regulator of the molecular chaperone Hsp90

21 January 2018

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Cancer cells harboring MET gene amplification activate alternative signaling pathways to escape MET inhibition but remain sensitive to Hsp90 inhibitors

21 January 2018

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Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity

21 January 2018

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The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains

21 January 2018

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The middle domain of Hsp90 acts as a discriminator between different types of client proteins

21 January 2018

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Mutational analysis of Hsp90 function: interactions with a steroid receptor and a protein kinase

21 January 2018

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Intra- and intermonomer interactions are required to synergistically facilitate ATP hydrolysis in Hsp90.

21 January 2018

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Src-mediated phosphorylation of Hsp90 in response to vascular endothelial growth factor (VEGF) is required for VEGF receptor-2 signaling to endothelial NO synthase.

21 January 2018

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Hsp90 phosphorylation, Wee1 and the cell cycle

21 January 2018

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An acetylation site in the middle domain of Hsp90 regulates chaperone function

21 January 2018

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Lysine deacetylases Hda1 and Rpd3 regulate Hsp90 function thereby governing fungal drug resistance.

21 January 2018

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Class II histone deacetylases play pivotal roles in heat shock protein 90-mediated proteasomal degradation of vascular endothelial growth factor receptors

21 January 2018

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Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors.

21 January 2018

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HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

21 January 2018

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HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling

21 January 2018

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Regulation of the dynamics of hsp90 action on the glucocorticoid receptor by acetylation/deacetylation of the chaperone

21 January 2018

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HDAC6 regulates androgen receptor hypersensitivity and nuclear localization via modulating Hsp90 acetylation in castration-resistant prostate cancer

21 January 2018

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Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90

21 January 2018

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A simple yeast-based system for analyzing inhibitor resistance in the human cancer drug targets Hsp90alpha/beta

21 January 2018

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Mutations that increase both Hsp90 ATPase activity in vitro and Hsp90 drug resistance in vivo

21 January 2018

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A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

21 January 2018

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The co-chaperone Hch1 regulates Hsp90 function differently than its homologue Aha1 and confers sensitivity to yeast to the Hsp90 inhibitor NVP-AUY922

21 January 2018

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DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90

21 January 2018

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Acquired resistance to 17-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin) in glioblastoma cells

21 January 2018

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P-Glycoprotein-mediated resistance to Hsp90-directed therapy is eclipsed by the heat shock response

21 January 2018

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Abrogation of heat shock protein 70 induction as a strategy to increase antileukemia activity of heat shock protein 90 inhibitor 17-allylamino-demethoxy geldanamycin

21 January 2018

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Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis

21 January 2018

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Post-translational modification of heat-shock protein 90: impact on chaperone function

21 January 2018

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12 December 2020

Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228

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12 December 2020

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

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12 December 2020

Asymmetric Activation of the Hsp90 Dimer by Its Cochaperone Aha1

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12 December 2020

Targeting HSP90 by the novel inhibitor NVP-AUY922 reduces growth and angiogenesis of pancreatic cancer.

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12 December 2020

Chaperoning oncogenes: Hsp90 as a target of geldanamycin.

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12 December 2020

Reaction of geldanamycin and C17-substituted analogues with glutathione: product identifications and pharmacological implications

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12 December 2020

Mechanisms of resistance to ansamycin antibiotics in human breast cancer cell lines.

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12 December 2020

Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins

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12 December 2020

Binding of p23 and hsp90 during assembly with the progesterone receptor

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12 December 2020

Detecting HSP90 phosphorylation

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12 December 2020

Identifiers

DOI

10.4155/FMC.13.88

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29 August 2017

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