(Q38116494)

29 August 2017

Pathways mediating resolution of inflammation: when enough is too much (English)

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29 August 2017

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James N Fullerton

1

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Derek W Gilroy

object named as

Derek W Gilroy

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3

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author name string

Alastair J O'Brien

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2

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29 August 2017

1 September 2013

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29 August 2017

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29 August 2017

231

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29 August 2017

1

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29 August 2017

8-20

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Critical care and the global burden of critical illness in adults

29 August 2017

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Critical care: advances and future perspectives

21 January 2018

1 reference

Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

21 January 2018

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The epidemiology of severe sepsis in England, Wales and Northern Ireland, 1996 to 2004: secondary analysis of a high quality clinical database, the ICNARC Case Mix Programme Database

21 January 2018

1 reference

A genomic storm in critically injured humans

21 January 2018

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A novel model of common Toll-like receptor 4- and injury-induced transcriptional themes in human leukocytes

21 January 2018

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Gene-expression profiling of gram-positive and gram-negative sepsis in critically ill patients.

21 January 2018

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Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis

21 January 2018

1 reference

Insights into host responses against pathogens from transcriptional profiling.

21 January 2018

1 reference

Does severe non-infectious SIRS differ from severe sepsis? Results from a multi-centre Australian and New Zealand intensive care unit study.

21 January 2018

1 reference

The pathogenesis of sepsis

21 January 2018

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Septic shock in humans. Advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy

21 January 2018

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The pathophysiology and treatment of sepsis

21 January 2018

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Mechanisms of mortality in early and late sepsis.

21 January 2018

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Contribution of anti-inflammatory/immune suppressive processes to the pathology of sepsis

21 January 2018

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Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality.

21 January 2018

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Chronic sepsis mortality characterized by an individualized inflammatory response

21 January 2018

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The determinants of hospital mortality among patients with septic shock receiving appropriate initial antibiotic treatment*.

21 January 2018

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Impact of nosocomial infections on clinical outcome and resource consumption in critically ill patients

21 January 2018

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Macroscopic postmortem findings in 235 surgical intensive care patients with sepsis

21 January 2018

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Predictors of 30-day mortality and hospital costs in patients with ventilator-associated pneumonia attributed to potentially antibiotic-resistant gram-negative bacteria

21 January 2018

1 reference

Normal responses to injury prevent systemic inflammation and can be immunosuppressive

21 January 2018

1 reference

Anti-inflammatory mechanisms of sepsis

21 January 2018

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21 January 2018

1 reference

Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis

21 January 2018

1 reference

Leukocyte apoptosis and its significance in sepsis and shock

21 January 2018

1 reference

Immunosuppression in patients who die of sepsis and multiple organ failure

21 January 2018

1 reference

Leukocyte phenotyping to stratify septic shock patients.

21 January 2018

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Clinical relevance of the severe abnormalities of the T cell compartment in septic shock patients

21 January 2018

1 reference

A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis

21 January 2018

1 reference

The function of neutrophils in sepsis

21 January 2018

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Sepsis induces early alterations in innate immunity that impact mortality to secondary infection

21 January 2018

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The compensatory anti-inflammatory response syndrome (CARS) in critically ill patients

21 January 2018

1 reference

Immunosuppression following surgical and traumatic injury

21 January 2018

1 reference

Molecular and cellular aspects of sepsis-induced immunosuppression

21 January 2018

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Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial.

21 January 2018

1 reference

Immunomodulatory therapy for sepsis: an update

21 January 2018

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A systematic review of randomized controlled trials exploring the effect of immunomodulative interventions on infection, organ failure, and mortality in trauma patients

21 January 2018

1 reference

New perspectives on immunomodulatory therapy for bacteraemia and sepsis

21 January 2018

1 reference

Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways

21 January 2018

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Resolution of inflammation: state of the art, definitions and terms

21 January 2018

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CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury

21 January 2018

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Novel biphasic role for lymphocytes revealed during resolving inflammation

21 January 2018

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Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP.

21 January 2018

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Nonresolving inflammation

21 January 2018

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Hanging in the balance: endogenous anti-inflammatory mechanisms in tissue repair and fibrosis

21 January 2018

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Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not?

21 January 2018

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Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators

21 January 2018

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Neutrophil paralysis in sepsis

21 January 2018

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C5a-mediated neutrophil dysfunction is RhoA-dependent and predicts infection in critically ill patients

21 January 2018

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Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation

21 January 2018

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Neutrophil clearance: when the party is over, clean-up begins

21 January 2018

1 reference

Upregulation of reactive oxygen species generation and phagocytosis, and increased apoptosis in human neutrophils during severe sepsis and septic shock

21 January 2018

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Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activity

21 January 2018

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Transcriptome kinetics of circulating neutrophils during human experimental endotoxemia

21 January 2018

1 reference

Neutrophil apoptosis: a marker of disease severity in sepsis and sepsis-induced acute respiratory distress syndrome

21 January 2018

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Dysregulated expression of neutrophil apoptosis in the systemic inflammatory response syndrome.

21 January 2018

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Neutrophil beta2 integrins: moderators of life or death decisions

21 January 2018

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In vivo regulation of neutrophil apoptosis by C5a during sepsis.

21 January 2018

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Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis

21 January 2018

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Aspirin-triggered lipoxins override the apoptosis-delaying action of serum amyloid A in human neutrophils: a novel mechanism for resolution of inflammation

21 January 2018

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Neutrophils in development of multiple organ failure in sepsis

21 January 2018

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Contribution of neutrophils to acute lung injury

21 January 2018

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The acute respiratory distress syndrome

21 January 2018

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Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis

21 January 2018

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Apoptosis is essential for neutrophil functional shutdown and determines tissue damage in experimental pneumococcal meningitis

21 January 2018

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15-epi-lipoxin A4 inhibits myeloperoxidase signaling and enhances resolution of acute lung injury

21 January 2018

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Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation

21 January 2018

1 reference

Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation

21 January 2018

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Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections

21 January 2018

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Resolvin D2 restores neutrophil directionality and improves survival after burns

21 January 2018

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Infection regulates pro-resolving mediators that lower antibiotic requirements

21 January 2018

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Modulation of the Bcl-2 family blocks sepsis-induced depletion of dendritic cells and macrophages.

21 January 2018

1 reference

Apoptosis in sepsis: mechanisms, clinical impact and potential therapeutic targets.

21 January 2018

1 reference

Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis

21 January 2018

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TRAIL limits excessive host immune responses in bacterial meningitis

21 January 2018

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Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) improves the innate immune response and enhances survival in murine polymicrobial sepsis

21 January 2018

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IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis.

21 January 2018

1 reference

CD4+ lymphocytes control gut epithelial apoptosis and mediate survival in sepsis

21 January 2018

1 reference

Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis

21 January 2018

1 reference

Cecal ligation and puncture-induced impairment of innate immune function does not occur in the absence of caspase-1

21 January 2018

1 reference

Inhibition of Fas/Fas ligand signaling improves septic survival: differential effects on macrophage apoptotic and functional capacity

21 January 2018

1 reference

PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis

21 January 2018

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Apoptosis and caspases regulate death and inflammation in sepsis

21 January 2018

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Apoptosis in sepsis: a new target for therapeutic exploration

21 January 2018

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Death-defying immunity: do apoptotic cells influence antigen processing and presentation?

21 January 2018

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Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2/EP2 signaling

21 January 2018

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Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF

21 January 2018

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Corpse clearance defines the meaning of cell death

21 January 2018

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Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells

21 January 2018

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The induction of tolerance by dendritic cells that have captured apoptotic cells

21 January 2018

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Innate immune recognition of infected apoptotic cells directs T(H)17 cell differentiation.

21 January 2018

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21 January 2018

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Modulation of macrophage efferocytosis in inflammation

21 January 2018

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High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserine

21 January 2018

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HMGB1 inhibits macrophage activity in efferocytosis through binding to the alphavbeta3-integrin

21 January 2018

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Inhibition of neutrophil apoptosis by PAI-1.

21 January 2018

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PAI-1 inhibits neutrophil efferocytosis

21 January 2018

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Urokinase-type plasminogen activator inhibits efferocytosis of neutrophils

21 January 2018

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Vitronectin inhibits efferocytosis through interactions with apoptotic cells as well as with macrophages

21 January 2018

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Extracellular histones are major mediators of death in sepsis

21 January 2018

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Extracellular histones inhibit efferocytosis.

21 January 2018

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Drotrecogin alfa (activated) in adults with septic shock.

21 January 2018

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A non-lethal traumatic/hemorrhagic insult strongly modulates the compartment-specific PAI-1 response in the subsequent polymicrobial sepsis

21 January 2018

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Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages

21 January 2018

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Trypanosoma cruzi: the role of PGE2 in immune response during the acute phase of experimental infection

21 January 2018

1 reference

Prostaglandin E2 inhibits alveolar macrophage phagocytosis through an E-prostanoid 2 receptor-mediated increase in intracellular cyclic AMP.

21 January 2018

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Prostaglandin E2 suppresses bacterial killing in alveolar macrophages by inhibiting NADPH oxidase

21 January 2018

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Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

21 January 2018

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E-prostanoid 2 receptor signaling suppresses lung innate immunity against Streptococcus pneumoniae.

21 January 2018

1 reference

Prostaglandin E2 restrains macrophage maturation via E prostanoid receptor 2/protein kinase A signaling.

21 January 2018

1 reference

Induction of apoptosis in thymocytes by prostaglandin E2 in vivo

21 January 2018

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Prostaglandins antagonistically control Bax activation during apoptosis

21 January 2018

1 reference

Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage death

21 January 2018

1 reference

Prostaglandin E2 promotes the survival of bone marrow-derived dendritic cells

21 January 2018

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Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation

21 January 2018

1 reference

E-prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infection

21 January 2018

1 reference

Cyclooxygenase inhibition in sepsis: is there life after death?

21 January 2018

1 reference

Macrophage plasticity and polarization: in vivo veritas

21 January 2018

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Monocyte and macrophage heterogeneity

21 January 2018

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The chemokine system in diverse forms of macrophage activation and polarization

21 January 2018

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Macrophage polarization and bacterial infections

21 January 2018

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Alternative activation of macrophages

21 January 2018

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Transcriptomic analyses of murine resolution-phase macrophages

21 January 2018

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Myeloid-derived suppressor cells as regulators of the immune system

21 January 2018

1 reference

Myeloid-derived suppressor cell heterogeneity and subset definition.

21 January 2018

1 reference

Gr-1+CD115+ Immature Myeloid Suppressor Cells Mediate the Development of Tumor-Induced T Regulatory Cells and T-Cell Anergy in Tumor-Bearing Host

21 January 2018

1 reference

MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis

21 January 2018

1 reference

Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function.

21 January 2018

1 reference

Myeloid-derived suppressor cells evolve during sepsis and can enhance or attenuate the systemic inflammatory response

21 January 2018

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Myeloid-derived suppressor cells control microbial sepsis.

21 January 2018

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Myeloid-derived suppressor cells accumulate in the liver site after sepsis to induce immunosuppression

21 January 2018

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A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma

21 January 2018

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Cutting Edge: LPS-Induced Emergency Myelopoiesis Depends on TLR4-Expressing Nonhematopoietic Cells

21 January 2018

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Cutting edge: Type I IFN drives emergency myelopoiesis and peripheral myeloid expansion during chronic TLR7 signaling

21 January 2018

1 reference

A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1.

21 January 2018

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Myeloid-derived suppressor cells in sepsis: friend or foe?

21 January 2018

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Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans

21 January 2018

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Myeloid-derived suppressor cells in parasitic infections

21 January 2018

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In vivo suppressive function of myeloid-derived suppressor cells is limited to the inflammatory site

21 January 2018

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Characterization and modulation of the immunosuppressive phase of sepsis

21 January 2018

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Increased susceptibility to Candida infection following cecal ligation and puncture

21 January 2018

1 reference

Regulatory T cell populations in sepsis and trauma.

21 January 2018

1 reference

Regulatory T cells: friend or foe in immunity to infection?

21 January 2018

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FOXP3 modifies the phenotypic and functional properties of regulatory T cells

21 January 2018

1 reference

The role of T regulatory cells in human sepsis

21 January 2018

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Natural regulatory T cells in infectious disease

21 January 2018

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Marked elevation of human circulating CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysis.

21 January 2018

1 reference

Sepsis is characterized by the increases in percentages of circulating CD4+CD25+ regulatory T cells and plasma levels of soluble CD25.

21 January 2018

1 reference

Association between regulatory T cell activity and sepsis and outcome of severely burned patients: a prospective, observational study

21 January 2018

1 reference

The relationship between CD4+CD25+CD127- regulatory T cells and inflammatory response and outcome during shock states

21 January 2018

1 reference

The post sepsis-induced expansion and enhanced function of regulatory T cells create an environment to potentiate tumor growth

21 January 2018

1 reference

Increased circulating regulatory T cells (CD4(+)CD25 (+)CD127 (-)) contribute to lymphocyte anergy in septic shock patients

21 January 2018

1 reference

Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis.

21 January 2018

1 reference

The contribution of CD4+ CD25+ T-regulatory-cells to immune suppression in sepsis

21 January 2018

1 reference

Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells.

21 January 2018

1 reference

Depletion of natural CD4+CD25+ T regulatory cells with anti-CD25 antibody does not change the course of Pseudomonas aeruginosa-induced acute lung infection in mice.

21 January 2018

1 reference

Regulatory T cells reduce acute lung injury fibroproliferation by decreasing fibrocyte recruitment

21 January 2018

1 reference

Adoptive transfer of in vitro-stimulated CD4+CD25+ regulatory T cells increases bacterial clearance and improves survival in polymicrobial sepsis

21 January 2018

1 reference

The kinetics of T regulatory cells in shock: beyond sepsis.

21 January 2018

1 reference

The outcome of polymicrobial sepsis is independent of T and B cells

21 January 2018

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B cells enhance early innate immune responses during bacterial sepsis

21 January 2018

1 reference

Dysregulated cytokine expression by CD4+ T cells from post-septic mice modulates both Th1 and Th2-mediated granulomatous lung inflammation

21 January 2018

1 reference

Inflammatory resolution: new opportunities for drug discovery

21 January 2018

1 reference

Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction

21 January 2018

1 reference

21 January 2018

Gone but not forgotten

1 reference

Immunosuppressive effects of apoptotic cells

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/PATH.4232

1 reference

29 August 2017

1 reference

PubMed ID

23794437