(Q38120833)

29 August 2017

title

Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications (English)

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29 August 2017

Nico Scheer

1

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29 August 2017

C Roland Wolf

series ordinal

2

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29 August 2017

language of work or name

English

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publication date

11 July 2013

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29 August 2017

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29 August 2017

volume

44

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29 August 2017

issue

2

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29 August 2017

page(s)

96-108

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The impact of CYP2E1 on the development of alcoholic liver disease as studied in a transgenic mouse model

29 August 2017

cites work

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Only low levels of exogenous N-acetyltransferase can be achieved in transgenic mice.

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N-acetyltransferase 2 activity and folate levels

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Urinary metabolite profiling reveals CYP1A2-mediated metabolism of NSC686288 (aminoflavone).

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Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus.

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Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity

21 January 2018

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Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha

21 January 2018

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Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate

21 January 2018

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Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for CYP1A1 and CYP1A2.

21 January 2018

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Growth hormone determines sexual dimorphism of hepatic cytochrome P450 3A4 expression in transgenic mice.

21 January 2018

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The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity

21 January 2018

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Theophylline pharmacokinetics: comparison of Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+/+) wild-type mice.

21 January 2018

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Genomically humanized mice: technologies and promises

21 January 2018

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For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential

21 January 2018

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Generation of 'humanized' hCYP1A1_1A2_Cyp1a1/1a2(-/-) mouse line

21 January 2018

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Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice

21 January 2018

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Metabolites in safety testing: "MIST" for the clinical pharmacologist

21 January 2018

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Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus

21 January 2018

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Membrane transporters in drug development

21 January 2018

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Expression of the Human CYP3A4 Gene in the Small Intestine of Transgenic Mice: In Vitro Metabolism and Pharmacokinetics of Midazolam

21 January 2018

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Cytochrome p450 and chemical toxicology

21 January 2018

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Enhanced acetaminophen toxicity by activation of the pregnane X receptor

21 January 2018

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Pregnancy Effects on Lamotrigine Levels

21 January 2018

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PXR/CYP3A4-humanized mice for studying drug-drug interactions involving intestinal P-glycoprotein

21 January 2018

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Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus

21 January 2018

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Oxidative stress and regulation of anti-oxidant enzymes in cytochrome P4502E1 transgenic mouse model of non-alcoholic fatty liver

21 January 2018

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Overexpression of liver-specific cytochrome P4502E1 impairs hepatic insulin signaling in a transgenic mouse model of nonalcoholic fatty liver disease

21 January 2018

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Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans.

21 January 2018

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Metabolomics reveals the metabolic map of procainamide in humans and mice.

21 January 2018

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Establishment of transgenic mice carrying human fetus-specific CYP3A7.

21 January 2018

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https://api.crossref.org/works/10.3109%2F00498254.2013.815831

Regulation of human CYP2C18 and CYP2C19 in transgenic mice: influence of castration, testosterone, and growth hormone

21 January 2018

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https://api.crossref.org/works/10.3109%2F00498254.2013.815831

Generation of mice transgenic for human CYP2C18 and CYP2C19: characterization of the sexually dimorphic gene and enzyme expression

21 January 2018

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Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice

21 January 2018

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https://api.crossref.org/works/10.3109%2F00498254.2013.815831

A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4

21 January 2018

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Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

21 January 2018

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Paracetamol metabolism in pregnancy

21 January 2018

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Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage

21 January 2018

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Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis

21 January 2018

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Clarifying adverse drug events: a clinician's guide to terminology, documentation, and reporting

21 January 2018

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Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities

21 January 2018

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The human intestinal cytochrome P450 "pie".

21 January 2018

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Safety assessment of drug metabolites: implications of regulatory guidance and potential application of genetically engineered mouse models that express human P450s.

21 January 2018

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https://api.crossref.org/works/10.3109%2F00498254.2013.815831

Metabolites in safety testing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.815831

Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.

21 January 2018

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Comparative cytochrome P450 -1A1, -2A6, -2B6, -2C, -2D6, -2E1, -3A5 and -4B1 expressions in human larynx tissue analysed at mRNA level.

21 January 2018

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https://api.crossref.org/works/10.3109%2F00498254.2013.815831

Generation and characterization of a novel multidrug resistance protein 2 humanized mouse line

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.815831

Modeling human cytochrome P450 2D6 metabolism and drug-drug interaction by a novel panel of knockout and humanized mouse lines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.815831

In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.815831

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.815831

Xenobiotic receptor humanized mice and their utility

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.815831

Effects of monoamine oxidase inhibitor and cytochrome P450 2D6 status on 5-methoxy-N,N-dimethyltryptamine metabolism and pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.815831

Liver-selective expression of human arylamine N-acetyltransferase NAT2 in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.815831

Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.815831

Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (SLCO1B1).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.815831

Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.815831

Midazolam and cyclosporin a metabolism in transgenic mice with liver-specific expression of human CYP3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.815831

Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.815831

Inhibition and stimulation of intestinal and hepatic CYP3A activity: studies in humanized CYP3A4 transgenic mice using triazolam

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.815831

Intestinal cytochrome P450 3A plays an important role in the regulation of detoxifying systems in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.815831

Midazolam metabolism in cytochrome P450 3A knockout mice can be attributed to up-regulated CYP2C enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.815831

Generation and characterization of a CYP2A13/2B6/2F1-transgenic mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.815831

Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.815831

The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.815831

Potential role for human cytochrome P450 3A4 in estradiol homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.815831

Inhibition of human UGT2B7 gene expression in transgenic mice by the constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.815831

Generation and characterization of a transgenic mouse model with hepatic expression of human CYP2A6.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.815831

Dubin-Johnson and Rotor syndromes: molecular basis and pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2013.815831

10.3109/00498254.2013.815831

21 January 2018

Identifiers

DOI

1 reference

29 August 2017

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