(Q38137808)

29 August 2017

title

The insulin receptor changes conformation in unforeseen ways on ligand binding: sharpening the picture of insulin receptor activation (English)

1 reference

29 August 2017

1 reference

1 reference

John G Menting

2

0 references

Michael C Lawrence

object named as

Michael C Lawrence

series ordinal

3

0 references

author name string

Colin W Ward

series ordinal

1

1 reference

29 August 2017

language of work or name

English

0 references

publication date

28 August 2013

1 reference

29 August 2017

1 reference

29 August 2017

volume

35

1 reference

29 August 2017

issue

11

1 reference

29 August 2017

page(s)

945-54, doi/10.1002/bies.201370111

1 reference

Insulin interactions with its receptors: experimental evidence for negative cooperativity.

29 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Insight into the molecular basis for the kinetic differences between the two insulin receptor isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

How insulin engages its primary binding site on the insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Structure of Rhombohedral 2 Zinc Insulin Crystals

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

The disulphide bonds of insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Insulin and its receptor: structure, function and evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Importance of the solvent-exposed residues of the insulin B chain alpha-helix for receptor binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Alanine scanning of a putative receptor binding surface of insulin-like growth factor-I

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

A novel approach to identify two distinct receptor binding surfaces of insulin-like growth factor II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

On the tertiary structure of the extracellular domains of the epidermal growth factor and insulin receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

N-linked glycans of the human insulin receptor and their distribution over the crystal structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

The location and characterisation of the O-linked glycans of the human insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

SH2 domains, interaction modules and cellular wiring

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

High-throughput phosphotyrosine profiling using SH2 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Structure of the insulin receptor ectodomain reveals a folded-over conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Expression and characterization of a 70-kDa fragment of the insulin receptor that binds insulin. Minimizing ligand binding domain of the insulin receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Identification of common ligand binding determinants of the insulin and insulin-like growth factor 1 receptors. Insights into mechanisms of ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Diabetes-associated mutations in insulin: consecutive residues in the B chain contact distinct domains of the insulin receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

The insulin and EGF receptor structures: new insights into ligand-induced receptor activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Complementation analysis demonstrates that insulin cross-links both alpha subunits in a truncated insulin receptor dimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

α-Helical element at the hormone-binding surface of the insulin receptor functions as a signaling element to activate its tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Receptor binding redefined by a structural switch in a mutant human insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

A structural switch in a mutant insulin exposes key residues for receptor binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Implications for the active form of human insulin based on the structural convergence of highly active hormone analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Diabetes-associated mutations in human insulin: crystal structure and photo-cross-linking studies of a-chain variant insulin Wakayama.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Fine details of IGF-1R activation, inhibition, and asymmetry determined by associated hydrogen /deuterium-exchange and peptide mass mapping

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

A comparative structural bioinformatics analysis of the insulin receptor family ectodomain based on phylogenetic information.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Insulin receptor-related receptor as an extracellular alkali sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Localization of the insulin-binding site to the cysteine-rich region of the insulin receptor alpha-subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Structure of insulin in 4-zinc insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Chiral mutagenesis of insulin. Foldability and function are inversely regulated by a stereospecific switch in the B chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

High-affinity insulin binding: insulin interacts with two receptor ligand binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Mutational analysis of the N-linked glycosylation sites of the human insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Solution structure of ectodomains of the insulin receptor family: the ectodomain of the type 1 insulin-like growth factor receptor displays asymmetry of ligand binding accompanied by limited conformational change

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Molecular dynamics of insulin/IGF-I receptor transmembrane signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

A novel human insulin receptor gene mutation uniquely inhibits insulin binding without impairing posttranslational processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Two mutant alleles of the insulin receptor gene in a family with a genetic form of insulin resistance: a 10 base pair deletion in exon 1 and a mutation substituting serine for asparagine-462.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Hormone-triggered conformational changes within the insulin-receptor ectodomain: requirement for transmembrane anchors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Negative cooperativity in the insulin-like growth factor-I receptor and a chimeric IGF-I/insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

High affinity insulin binding by soluble insulin receptor extracellular domain fused to a leucine zipper

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Dimeric fragment of the insulin receptor alpha-subunit binds insulin with full holoreceptor affinity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Role of insulin receptor dimerization domains in ligand binding, cooperativity, and modulation by anti-receptor antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Insulin receptor transmembrane signaling: evidence for an intermolecular oligomerization mechanism of activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Conformational coupling across the plasma membrane in activation of the EGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Architecture and membrane interactions of the EGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Ligand-induced activation of the insulin receptor: a multi-step process involving structural changes in both the ligand and the receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Landmarks in insulin research

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Insulin/IGF‐1 hybrid receptors: Implications for the dominant‐negative phenotype in syndromes of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Autoinhibition of the insulin-like growth factor I receptor by the juxtamembrane region

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

Structural analysis of macromolecular assemblies by electron microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

A third fibronectin-type-III domain in the insulin-family receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

An Investigation of the Ligand Binding Properties and Negative Cooperativity of Soluble Insulin-like Growth Factor Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIES.201300065

21 January 2018

Identifiers

DOI

10.1002/BIES.201300065

1 reference

29 August 2017

1 reference