(Q38140116)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24053899%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

title

Activin receptor-like kinase 1 as a target for anti-angiogenesis therapy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24053899%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

author

Lukas J.A.C. Hawinkels

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24053899%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

3

Peter Ten Dijke

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24053899%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

author name string

Amaya Garcia de Vinuesa

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24053899%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

language of work or name

English

0 references

publication date

21 September 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24053899%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Investigational Drugs

22 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24053899%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

volume

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24053899%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24053899%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

page(s)

1371-1383

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24053899%20AND%20SRC:MED&resulttype=core&format=json

Molecular regulation of angiogenesis and lymphangiogenesis

22 February 2020

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21 January 2018

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Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin shedding inhibits tumor angiogenesis.

21 January 2018

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The shedding of betaglycan is regulated by pervanadate and mediated by membrane type matrix metalloprotease-1.

21 January 2018

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ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2

21 January 2018

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Characterization of the human Activin-A receptor type II-like kinase 1 (ACVRL1) promoter and its regulation by Sp1

21 January 2018

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Isolation of a regulatory region of activin receptor-like kinase 1 gene sufficient for arterial endothelium-specific expression

21 January 2018

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Vascular injury triggers Krüppel-like factor 6 mobilization and cooperation with specificity protein 1 to promote endothelial activation through upregulation of the activin receptor-like kinase 1 gene.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Nonoverlapping expression patterns of ALK1 and ALK5 reveal distinct roles of each receptor in vascular development

21 January 2018

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Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis

21 January 2018

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21 January 2018

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Activin receptor-like kinase 1 is essential for placental vascular development in mice

21 January 2018

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Interaction between alk1 and blood flow in the development of arteriovenous malformations

21 January 2018

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21 January 2018

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21 January 2018

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Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Retention in the endoplasmic reticulum is the underlying mechanism of some hereditary haemorrhagic telangiectasia type 2 ALK1 missense mutations.

21 January 2018

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21 January 2018

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21 January 2018

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Pulmonary hypertension in adult Alk1 heterozygous mice due to oxidative stress.

21 January 2018

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Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.837884

Characterization of type I receptors for transforming growth factor-beta and activin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.837884

BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.837884

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.837884

Structure of the Alk1 extracellular domain and characterization of its bone morphogenetic protein (BMP) binding properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.837884

Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.837884

BMP-9 induced endothelial cell tubule formation and inhibition of migration involves Smad1 driven endothelin-1 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.837884

Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.837884

Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2013.837884

Age-dependent alteration of TGF-β signalling in osteoarthritis

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2013.837884

Bone morphogenetic protein-9 activates Smad and ERK pathways and supports human osteoclast function and survival in vitro

21 January 2018

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TGFbeta/BMP type I receptors ALK1 and ALK2 are essential for BMP9-induced osteogenic signaling in mesenchymal stem cells

21 January 2018

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21 January 2018

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21 January 2018

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Evaluation of the prognostic value of TGF-β superfamily type I receptor and TGF-β type II receptor expression in nasopharyngeal carcinoma using high-throughput tissue microarrays

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2013.837884

Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.837884

Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.837884

Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.837884

ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.837884

ALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.837884

Anti-human activin receptor-like kinase 1 (ALK1) antibody attenuates bone morphogenetic protein 9 (BMP9)-induced ALK1 signaling and interferes with endothelial cell sprouting

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.837884

Targeting activin receptor-like kinase 1 inhibits angiogenesis and tumorigenesis through a mechanism of action complementary to anti-VEGF therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.837884

A phase I first-in-human study of TRC105 (Anti-Endoglin Antibody) in patients with advanced cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.837884

Endoglin for tumor imaging and targeted cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.837884

BMP9 and BMP10 are critical for postnatal retinal vascular remodeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2013.837884

10.1517/13543784.2013.837884

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24053899%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference