(Q38160660)

30 August 2017

The autophagosome: origins unknown, biogenesis complex (English)

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Gene Ontology release 2020-05-02

30 August 2017

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3

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30 August 2017

Christopher A Lamb

1

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Tamotsu Yoshimori

series ordinal

2

object named as

Tamotsu Yoshimori

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30 August 2017

8 November 2013

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Nature Reviews Molecular Cell Biology

30 August 2017

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30 August 2017

14

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30 August 2017

12

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30 August 2017

759-774

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https://scigraph.springernature.com/pub.10.1038/nrm3696

30 August 2017

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cites work

Autophagy in human health and disease

1 reference

Physiological role of autophagy as an intracellular recycling system: with an emphasis on nutrient metabolism

31 March 2020

1 reference

Post-Golgi Sec proteins are required for autophagy in Saccharomyces cerevisiae

31 March 2020

1 reference

Membrane delivery to the yeast autophagosome from the Golgi-endosomal system

31 March 2020

1 reference

RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly

31 March 2020

1 reference

Exit from the Golgi is required for the expansion of the autophagosomal phagophore in yeast Saccharomyces cerevisiae

31 March 2020

1 reference

Characterization of the isolation membranes and the limiting membranes of autophagosomes in rat hepatocytes by lectin cytochemistry

31 March 2020

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Plasma membrane contributes to the formation of pre-autophagosomal structures

31 March 2020

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Mitochondria supply membranes for autophagosome biogenesis during starvation

31 March 2020

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Endocytosis and autophagy: Shared machinery for degradation.

31 March 2020

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Seeing is believing: the impact of electron microscopy on autophagy research

31 March 2020

1 reference

Cytolysomes and mitochondrial degeneration

31 March 2020

1 reference

Studies on vinblastine-induced autophagocytosis in mouse liver. V. A cytochemical study on the origin of membranes

31 March 2020

1 reference

Cytoplasmic components in hepatic cell lysosomes

31 March 2020

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Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction

31 March 2020

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Isolation of autophagocytosis mutants of Saccharomyces cerevisiae

31 March 2020

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Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae

31 March 2020

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Induction of autophagy and inhibition of tumorigenesis by beclin 1

31 March 2020

1 reference

The role of autophagy during the early neonatal starvation period

31 March 2020

1 reference

The role of Atg proteins in autophagosome formation

31 March 2020

1 reference

Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks

31 March 2020

1 reference

Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2.

31 March 2020

1 reference

Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage.

31 March 2020

1 reference

Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism

31 March 2020

1 reference

Architecture of the Atg17 Complex as a Scaffold for Autophagosome Biogenesis

31 March 2020

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The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

31 March 2020

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Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy

31 March 2020

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mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.

31 March 2020

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ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase.

31 March 2020

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Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes

31 March 2020

1 reference

The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes.

31 March 2020

1 reference

Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation.

31 March 2020

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Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation

31 March 2020

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Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets.

31 March 2020

1 reference

Two-Site Recognition of Phosphatidylinositol 3-Phosphate by PROPPINs in Autophagy

31 March 2020

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Structural and functional characterization of the two phosphoinositide binding sites of PROPPINs, a β-propeller protein family

31 March 2020

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Structure-based analyses reveal distinct binding sites for Atg2 and phosphoinositides in Atg18.

31 March 2020

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Control of autophagy initiation by phosphoinositide 3-phosphatase Jumpy

31 March 2020

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Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy

31 March 2020

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The molecular machinery of autophagy: unanswered questions

31 March 2020

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An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure

31 March 2020

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LC3 and GATE-16 N termini mediate membrane fusion processes required for autophagosome biogenesis

31 March 2020

1 reference

Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy.

31 March 2020

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An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis

31 March 2020

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Atg9 vesicles are an important membrane source during early steps of autophagosome formation

31 March 2020

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Membrane shaping by the Bin/amphiphysin/Rvs (BAR) domain protein superfamily

31 March 2020

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Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L).

31 March 2020

1 reference

Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L.

31 March 2020

1 reference

A HORMA domain in Atg13 mediates PI 3-kinase recruitment in autophagy

31 March 2020

1 reference

Dynamic association of the ULK1 complex with omegasomes during autophagy induction.

31 March 2020

1 reference

mTOR signaling in growth control and disease

31 March 2020

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

31 March 2020

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Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1

31 March 2020

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

31 March 2020

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mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

31 March 2020

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TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1

31 March 2020

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

31 March 2020

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Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

31 March 2020

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

31 March 2020

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

31 March 2020

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Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes

31 March 2020

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Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling

31 March 2020

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Activation of the Akt-NF-kappaB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response

31 March 2020

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Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains

31 March 2020

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Hypoxia induces the expression of the pro-apoptotic gene BNIP3

31 March 2020

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Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L.

31 March 2020

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Nix is a selective autophagy receptor for mitochondrial clearance

31 March 2020

1 reference

The pathways of mitophagy for quality control and clearance of mitochondria

31 March 2020

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Exorcising the exocyst complex

31 March 2020

1 reference

Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase

31 March 2020

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Arf6 promotes autophagosome formation via effects on phosphatidylinositol 4,5-bisphosphate and phospholipase D.

31 March 2020

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Autophagosome precursor maturation requires homotypic fusion

31 March 2020

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Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

31 March 2020

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Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

31 March 2020

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A novel mammalian trans-membrane protein reveals an alternative initiation pathway for autophagy

31 March 2020

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The VMP1-Beclin 1 interaction regulates autophagy induction

31 March 2020

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A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

31 March 2020

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3D tomography reveals connections between the phagophore and endoplasmic reticulum

31 March 2020

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Autophagosomes form at ER-mitochondria contact sites

31 March 2020

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Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

31 March 2020

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Endoplasmic reticulum-mitochondria contacts: function of the junction

31 March 2020

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The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes

31 March 2020

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Membrane lipids: where they are and how they behave

31 March 2020

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Autophagosome formation depends on the small GTPase Rab1 and functional ER exit sites

31 March 2020

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The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis

31 March 2020

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ER exit sites are physical and functional core autophagosome biogenesis components

31 March 2020

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Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae

31 March 2020

1 reference

Coordinated regulation of autophagy by p38alpha MAPK through mAtg9 and p38IP

31 March 2020

1 reference

Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes

31 March 2020

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TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes

31 March 2020

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Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy

31 March 2020

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Atg9 vesicles recruit vesicle-tethering proteins Trs85 and Ypt1 to the autophagosome formation site

31 March 2020

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Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways

31 March 2020

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α-Synuclein impairs macroautophagy: implications for Parkinson's disease.

31 March 2020

1 reference

Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase

31 March 2020

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Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy

31 March 2020

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Network organization of the human autophagy system

31 March 2020

1 reference

Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation

31 March 2020

1 reference

RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins

31 March 2020

1 reference

OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation

31 March 2020

1 reference

Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network

31 March 2020

1 reference

Identification of a candidate therapeutic autophagy-inducing peptide

31 March 2020

1 reference

Rab conversion as a mechanism of progression from early to late endosomes

31 March 2020

1 reference

The phospholipase D1 pathway modulates macroautophagy

31 March 2020

1 reference

Membrane remodeling by the PX-BAR protein SNX18 promotes autophagosome formation

31 March 2020

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Diverse autophagosome membrane sources coalesce in recycling endosomes.

31 March 2020

1 reference

Bacterial subversion of host innate immune pathways

31 March 2020

1 reference

When autophagy meets viruses: a double-edged sword with functions in defense and offense

31 March 2020

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Aggrephagy: selective disposal of protein aggregates by macroautophagy.

31 March 2020

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Excess peroxisomes are degraded by autophagic machinery in mammals

31 March 2020

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

31 March 2020

1 reference

Chaperone-mediated autophagy: molecular mechanisms and physiological relevance

31 March 2020

1 reference

Microautophagy in mammalian cells: revisiting a 40-year-old conundrum

31 March 2020

1 reference

The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella

31 March 2020

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p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

31 March 2020

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Structural basis for sorting mechanism of p62 in selective autophagy

31 March 2020

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Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins.

31 March 2020

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The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy

31 March 2020

1 reference

siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy

31 March 2020

1 reference

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

31 March 2020

1 reference

Atg101, a novel mammalian autophagy protein interacting with Atg13

31 March 2020

1 reference

A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy

31 March 2020

1 reference

Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase

31 March 2020

1 reference

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

31 March 2020

1 reference

Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p

31 March 2020

1 reference

LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

31 March 2020

1 reference

A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy

31 March 2020

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Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

31 March 2020

1 reference

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

31 March 2020

1 reference

Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate

31 March 2020

1 reference

Role of HRB in clathrin-dependent endocytosis.

31 March 2020

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Cargo recognition during clathrin-mediated endocytosis: a team effort

31 March 2020

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Biological basket weaving: formation and function of clathrin-coated vesicles

31 March 2020

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31 March 2020

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

31 March 2020

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Lipid kinases: charging PtdIns(4,5)P2 synthesis

31 March 2020

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Molecular mechanisms of PLD function in membrane traffic.

31 March 2020

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Molecular mechanisms of clathrin-independent endocytosis.

31 March 2020

1 reference

Multiple roles for Arf6: sorting, structuring, and signaling at the plasma membrane

31 March 2020

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The dynamin superfamily: universal membrane tubulation and fission molecules?

31 March 2020

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Rab GTPases as coordinators of vesicle traffic

31 March 2020

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Regulation of TOR by small GTPases

31 March 2020

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SNAREs--engines for membrane fusion

31 March 2020

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Multisubunit tethering complexes and their role in membrane fusion

31 March 2020

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TRAPP complexes in membrane traffic: convergence through a common Rab.

31 March 2020

1 reference

Atg12-Atg5 conjugate enhances E2 activity of Atg3 by rearranging its catalytic site

31 March 2020

1 reference

Freeze-fracture of drug-induced autophagocytosis in the mouse exocrine pancreas

31 March 2020

1 reference

12 December 2020

A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system

1 reference

12 December 2020

The LIR motif - crucial for selective autophagy

1 reference

12 December 2020

Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRM3696

1 reference

PubMed ID

24201109

Dimensions Publication ID

30 August 2017

1039377484

0 references

Fatcat ID

release_cwrpuxl3z5crrfy332p4qva2lq

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/cwrpuxl3z5crrfy332p4qva2lq

24 November 2022

mapped directly with Wikidata item

PubMed ID

24201109

1 reference

PubMed ID

24201109