(Q38164841)

30 August 2017

title

Recapitulating the α-helix: nonpeptidic, low-molecular-weight ligands for the modulation of helix-mediated protein-protein interactions (English)

1 reference

protein-protein interaction

30 August 2017

main subject

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Maryanna Lanning

1

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30 August 2017

Steven Fletcher

series ordinal

2

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30 August 2017

publication date

1 December 2013

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Future Medicinal Chemistry

30 August 2017

published in

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30 August 2017

volume

5

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30 August 2017

issue

18

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30 August 2017

page(s)

2157-2174

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Protein surface recognition and proteomimetics: mimics of protein surface structure and function

30 August 2017

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Helix stabilization by Glu-...Lys+ salt bridges in short peptides of de novo design

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21 January 2018

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21 January 2018

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Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix

21 January 2018

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Development of a potent Bcl-x(L) antagonist based on alpha-helix mimicry

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The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner

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Development of a high-throughput fluorescence polarization assay for Bcl-x(L)

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21 January 2018

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Synthesis of functionalised aromatic oligamide rods

21 January 2018

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Relaxation of the rigid backbone of an oligoamide-foldamer-based α-helix mimetic: identification of potent Bcl-xL inhibitors.

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Small molecule protein-protein inhibitors for the p53-MDM2 interaction

21 January 2018

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21 January 2018

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Microwave assisted solid phase synthesis of highly functionalized N-alkylated oligobenzamide α-helix mimetics

21 January 2018

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The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions

21 January 2018

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Discovery of HIV fusion inhibitors targeting gp41 using a comprehensive α-helix mimetic library

21 January 2018

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Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target

21 January 2018

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Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein-protein interaction through structure-based drug design

21 January 2018

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21 January 2018

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Protein β-turn mimetics I. Design, synthesis, and evaluation in model cyclic peptides

21 January 2018

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Synthesis of pyridazine-based scaffolds as alpha-helix mimetics

21 January 2018

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Heterocyclic alpha-helix mimetics for targeting protein-protein interactions

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.13.176

Synthesis and biological evaluation of a 5-6-5 imidazole-phenyl-thiazole based alpha-helix mimetic

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.176

Design and modular parallel synthesis of a MCR derived alpha-helix mimetic protein-protein interaction inhibitor scaffold.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.176

Oligophenylenaminones as scaffolds for α-helix mimicry.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.176

Benzoylurea oligomers: synthetic foldamers that mimic extended alpha helices

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.176

Structure and function of benzoylurea-derived alpha-helix mimetics targeting the Bcl-x(L)/Bak binding interface

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.176

Biphenyls as potential mimetics of protein alpha-helix

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.176

Synthetic inhibitors of extended helix-protein interactions based on a biphenyl 4,4'-dicarboxamide scaffold

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.176

Hydrophobicity scales and computational techniques for detecting amphipathic structures in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.176

Amphipathic α-helix mimetics based on a 1,2-diphenylacetylene scaffold.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.176

Conformational properties of O-alkylated benzamides

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.176

Double-sided α-helix mimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.176

Amphiphilic α-helix mimetics based on a benzoylurea scaffold

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.13.176

21 January 2018

Identifiers

DOI

10.4155/FMC.13.176

1 reference

30 August 2017

1 reference