(Q38177305)

30 August 2017

title

Advances in the arsenal of tools available enabling the discovery of novel lantibiotics with therapeutic potential (English)

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30 August 2017

author name string

Stephanie Kate Sandiford

series ordinal

1

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30 August 2017

language of work or name

English

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publication date

13 January 2014

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Expert Opinion on Drug Discovery

30 August 2017

published in

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30 August 2017

volume

9

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30 August 2017

issue

3

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30 August 2017

page(s)

283-297

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Drugs for bad bugs: confronting the challenges of antibacterial discovery

30 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Mersacidin eradicates methicillin-resistant Staphylococcus aureus (MRSA) in a mouse rhinitis model.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Differential release of lipoteichoic and teichoic acids from Streptococcus pneumoniae as a result of exposure to beta-lactam antibiotics, rifamycins, trovafloxacin, and quinupristin-dalfopristin

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Lacticin 3147 displays activity in buffer against gram-positive bacterial pathogens which appear insensitive in standard plate assays.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Bacteriocins as alternative agents for control of multiresistant staphylococcal strains

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Production of bacteriocins by coagulase-negative staphylococci involved in bovine mastitis.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Bacteriocins Pep5 and epidermin inhibit Staphylococcus epidermidis adhesion to catheters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Assembly and stability of nisin-lipid II pores

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

The nisin-lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Characterization of new class III lantibiotics--erythreapeptin, avermipeptin and griseopeptin from Saccharopolyspora erythraea, Streptomyces avermitilis and Streptomyces griseus demonstrates stepwise N-terminal leader processing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Chemical synthesis of the lantibiotic lacticin 481 reveals the importance of lanthionine stereochemistry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Lantibiotics: peptides of diverse structure and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Biosynthesis, immunity, regulation, mode of action and engineering of the model lantibiotic nisin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Applications of the bacteriocin, nisin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Biosynthesis and mode of action of lantibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Bacterial lantibiotics: strategies to improve therapeutic potential.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Post-translational modification of therapeutic peptides by NisB, the dehydratase of the lantibiotic nisin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

NisB is required for the dehydration and NisC for the lanthionine formation in the post-translational modification of nisin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Nucleotide sequence of the lantibiotic Pep5 biosynthetic gene cluster and functional analysis of PepP and PepC. Evidence for a role of PepC in thioether formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Comparison of lantibiotic gene clusters and encoded proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Expression, purification, and characterization of EpiC, an enzyme involved in the biosynthesis of the lantibiotic epidermin, and sequence analysis of Staphylococcus epidermidis epiC mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Activity of mersacidin, a novel peptide, compared with that of vancomycin, teicoplanin, and daptomycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Structural characterization of lacticin 3147, a two-peptide lantibiotic with synergistic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Gallidermin: a new lanthionine-containing polypeptide antibiotic

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Posttranslational conversion of L-serines to D-alanines is vital for optimal production and activity of the lantibiotic lacticin 3147

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Heterologous expression and engineering studies of labyrinthopeptins, class III lantibiotics from Actinomadura namibiensis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Leader peptide-directed processing of labyrinthopeptin A2 precursor peptide by the modifying enzyme LabKC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Biosynthesis of bacteriocins in lactic acid bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Lipid II as a target for antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Lantibiotics from Geobacillus thermodenitrificans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Comparative effect of protein binding on the killing activities of teicoplanin and vancomycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Elucidation of the antimicrobial mechanism of mutacin 1140.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

New insights into the mechanism of action of lantibiotics--diverse biological effects by binding to the same molecular target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Insights into in vivo activities of lantibiotics from gallidermin and epidermin mode-of-action studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Structure determination of an immunopotentiator peptide, cinnamycin, complexed with lysophosphatidylethanolamine by 1H-NMR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Haloduracin α binds the peptidoglycan precursor lipid II with 2:1 stoichiometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Sequential actions of the two component peptides of the lantibiotic lacticin 3147 explain its antimicrobial activity at nanomolar concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

The co-evolution of host cationic antimicrobial peptides and microbial resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Resistance of Gram-positive bacteria to nisin is not determined by lipid II levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Role of acetate in production of an autoinducible class IIa bacteriocin in Carnobacterium piscicola A9b.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

The synthesis of the bacteriocin sakacin A is a temperature-sensitive process regulated by a pheromone peptide through a three-component regulatory system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Production of piscicolin 126 by Carnobacterium maltaromaticum UAL26 is controlled by temperature and induction peptide concentration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

The effect of osmotic stress on the production of nukacin ISK-1 from Staphylococcus warneri ISK-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Regulation of lantibiotic lacticin 481 production at the transcriptional level by acid pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Milk protein fragments induce the biosynthesis of macedocin, the lantibiotic produced by Streptococcus macedonicus ACA-DC 198.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Autoregulation of Nisin Biosynthesis in Lactococcus lactis by Signal Transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

The lantibiotic mersacidin is an autoinducing peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Small molecules with antimicrobial activity against E. coli and P. aeruginosa identified by high-throughput screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

A high-throughput screen identifies a new natural product with broad-spectrum antibacterial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Bacterial display and screening of posttranslationally thioether-stabilized peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Synergistic drug combinations for tuberculosis therapy identified by a novel high-throughput screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

High-throughput discovery of broad-spectrum peptide antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

A novel lantibiotic acting on bacterial cell wall synthesis produced by the uncommon actinomycete Planomonospora sp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Identification of a novel two-peptide lantibiotic, lichenicidin, following rational genome mining for LanM proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Genome mining for novel natural product discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Strategies for the discovery of new natural products by genome mining

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Genome mining for ribosomally synthesized natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

A mass spectrometry-guided genome mining approach for natural product peptidogenomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Target recognition, resistance, immunity and genome mining of class II bacteriocins from Gram-positive bacteria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Evolution of lanthipeptide synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Production of the novel two-peptide lantibiotic lichenicidin by Bacillus licheniformis DSM 13

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Gene cluster analysis for the biosynthesis of elgicins, novel lantibiotics produced by Paenibacillus elgii B69.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Genome sequence of the polymyxin-producing plant-probiotic rhizobacterium Paenibacillus polymyxa E681.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Complete genome sequence of Paenibacillus polymyxa SC2, a strain of plant growth-promoting Rhizobacterium with broad-spectrum antimicrobial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Isolation and identification of a Paenibacillus polymyxa strain that coproduces a novel lantibiotic and polymyxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

BAGEL3: Automated identification of genes encoding bacteriocins and (non-)bactericidal posttranslationally modified peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

A genome-wide survey of short coding sequences in streptococci.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

BACTIBASE: a new web-accessible database for bacteriocin characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

BACTIBASE second release: a database and tool platform for bacteriocin characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

antiSMASH 2.0--a versatile platform for genome mining of secondary metabolite producers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Detection of putative new mutacins by bioinformatic analysis using available web tools

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Lanthionine introduction into nukacin ISK-1 prepeptide by co-expression with modification enzyme NukM in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Production of lantipeptides in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Production of a class II two-component lantibiotic of Streptococcus pneumoniae using the class I nisin synthetic machinery and leader sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

The importance of the leader sequence for directing lanthionine formation in lacticin 481.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Cloning and analysis of the planosporicin lantibiotic biosynthetic gene cluster of Planomonospora alba.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Cloning and engineering of the cinnamycin biosynthetic gene cluster from Streptomyces cinnamoneus cinnamoneus DSM 40005

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Hyper-inducible expression system for streptomycetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Synthetic biotechnology to study and engineer ribosomal bottromycin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Designing and producing modified, new-to-nature peptides with antimicrobial activity by use of a combination of various lantibiotic modification enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Metagenome mining reveals polytheonamides as posttranslationally modified ribosomal peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

The dawning of a 'Golden era' in lantibiotic bioengineering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Chapter 22. Whole-cell generation of lantibiotic variants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Site-directed mutagenesis of the hinge region of nisinZ and properties of nisinZ mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Dissecting structural and functional diversity of the lantibiotic mersacidin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Follow the leader: the use of leader peptides to guide natural product biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

An engineered lantibiotic synthetase that does not require a leader peptide on its substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Production of dehydroamino acid-containing peptides by Lactococcus lactis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Microbial engineering of dehydro-amino acids and lanthionines in non-lantibiotic peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Heterologous production of the lantibiotic Ala(0)actagardine in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Protein engineering of lantibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Complete alanine scanning of the two-component lantibiotic lacticin 3147: generating a blueprint for rational drug design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Engineering dehydro amino acids and thioethers into peptides using lacticin 481 synthetase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Heterologous expression, biosynthesis, and mutagenesis of type II lantibiotics from Bacillus licheniformis in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

The vancomycin-nisin(1-12) hybrid restores activity against vancomycin resistant Enterococci

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Exploring the limits of bacterial identification by intact cell-mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

MALDI-TOF mass spectrometry of bacteria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Matrix-assisted laser desorption ionization--time of flight mass spectrometry of lipopeptide biosurfactants in whole cells and culture filtrates of Bacillus subtilis C-1 isolated from petroleum sludge

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Primer on agar-based microbial imaging mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Dereplication and de novo sequencing of nonribosomal peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Identification of post-translational modifications by blind search of mass spectra.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Enrichment analysis of phosphorylated proteins as a tool for probing the phosphoproteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Discovery of medically significant lantibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Emerging treatments in cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Organization of the genes encoding the biosynthesis of actagardine and engineering of a variant generation system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Pharmacodynamic activity of the lantibiotic MU1140.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Pharmacokinetic and pharmacodynamic evaluation of the lantibiotic MU1140.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Determining the structure and mode of action of microbisporicin, a potent lantibiotic active against multiresistant pathogens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Efficacy of the new lantibiotic NAI-107 in experimental infections induced by multidrug-resistant Gram-positive pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Evaluation of NVB302 versus vancomycin activity in an in vitro human gut model of Clostridium difficile infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

Selective enrichment of Ser-/Thr-phosphorylated peptides in the presence of Ser-/Thr-glycosylated peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.877882

10.1517/17460441.2014.877882

21 January 2018

Identifiers

DOI

1 reference

30 August 2017

1 reference