(Q38195304)

30 August 2017

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title

Organs-on-a-chip: a new tool for drug discovery (English)

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30 August 2017

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6

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30 August 2017

Vijayan Manoharan

4

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Alessandro Polini

object named as

Alessandro Polini

1

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author name string

Ljupcho Prodanov

2

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30 August 2017

Nupura S Bhise

3

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30 August 2017

Mehmet R Dokmeci

5

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30 August 2017

language of work or name

English

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publication date

12 March 2014

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Expert Opinion on Drug Discovery

30 August 2017

published in

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30 August 2017

volume

9

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30 August 2017

issue

4

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30 August 2017

page(s)

335-352

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Pharmacogenomics in clinical practice and drug development

30 August 2017

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Topographically-patterned porous membranes in a microfluidic device as an in vitro model of renal reabsorptive barriers

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BBB on chip: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function.

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Molecular control of cytoskeletal mechanics by hemodynamic forces

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A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice

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Reconstituting organ-level lung functions on a chip

21 January 2018

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A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells.

21 January 2018

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Human tissue-engineered blood vessels for adult arterial revascularization

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A human tissue-engineered vascular media: a new model for pharmacological studies of contractile responses

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Functional arteries grown in vitro

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Organs on Chips 2013.

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Organs-on-a-chip for drug discovery

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From laptop to benchtop to bedside: structure-based drug design on protein targets.

21 January 2018

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Modern drug discovery technologies: opportunities and challenges in lead discovery.

21 January 2018

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Species differences in drug transporters and implications for translating preclinical findings to humans

21 January 2018

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Scaling and systems biology for integrating multiple organs-on-a-chip

21 January 2018

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Can the pharmaceutical industry reduce attrition rates?

21 January 2018

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Microfluidic devices for in vitro studies on liver drug metabolism and toxicity

21 January 2018

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Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments.

21 January 2018

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Perifused monolayer cultures of rat hepatocytes as an improved in vitro system for studies on ureogenesis

21 January 2018

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An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture

21 January 2018

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Co-culture with mesenchymal stem cells enhances metabolic functions of liver cells in bioartificial liver system.

21 January 2018

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A microscale in vitro physiological model of the liver: predictive screens for drug metabolism and enzyme induction

21 January 2018

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A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

21 January 2018

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Chip-based P450 drug metabolism coupled to electrospray ionization-mass spectrometry detection

21 January 2018

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Microreactor microfluidic systems with human microsomes and hepatocytes for use in metabolite studies.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Vascularized and functional human liver from an iPSC-derived organ bud transplant.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Spheroid-based three-dimensional liver-on-a-chip to investigate hepatocyte-hepatic stellate cell interactions and flow effects

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Long-term maintenance of hepatocyte functional activity in co-culture: requirements for sinusoidal endothelial cells and dexamethasone

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Microscale culture of human liver cells for drug development.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Rapid heterogeneous liver-cell on-chip patterning via the enhanced field-induced dielectrophoresis trap

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Bile canaliculi formation by aligning rat primary hepatocytes in a microfluidic device

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Micro total bioassay system for ingested substances: assessment of intestinal absorption, hepatic metabolism, and bioactivity

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Engineers are from PDMS-land, Biologists are from Polystyrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

From the cellular perspective: exploring differences in the cellular baseline in macroscale and microfluidic cultures

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Optimizing ventricular fibers: uniform strain or stress, but not ATP consumption, leads to high efficiency

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Effect of tissue anisotropy on extracellular potential fields in canine myocardium in situ.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Engineered cardiac tissues

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Engineering the heart piece by piece: state of the art in cardiac tissue engineering

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Myofibrillar architecture in engineered cardiac myocytes

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Self-organization of muscle cell structure and function

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Evaluation of heart tissue viability under redox-magnetohydrodynamics conditions: toward fine-tuning flow in biological microfluidics applications.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Microfluidic systems to examine intercellular coupling of pairs of cardiac myocytes.

21 January 2018

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Development of polydimethylsiloxane substrates with tunable elastic modulus to study cell mechanobiology in muscle and nerve

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Hydrogel-coated microfluidic channels for cardiomyocyte culture

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Cardioprotection in stunned and hibernating myocardium

21 January 2018

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The cardiac persistent sodium current: an appealing therapeutic target?

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Microfluidic heart on a chip for higher throughput pharmacological studies

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Animal models of human cardiovascular disease, heart failure and hypertrophy

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Mouse models of long QT syndrome

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

In vitro microvessels for the study of angiogenesis and thrombosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

In vitro perfused human capillary networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

In vitro evaluation of the angiostatic potential of drugs using an endothelialized tissue-engineered connective tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Engineering of functional, perfusable 3D microvascular networks on a chip

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

A microfluidic platform for probing small artery structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Microfluidic devices for modeling cell–cell and particle–cell interactions in the microvasculature

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

SyM-BBB: a microfluidic Blood Brain Barrier model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

The airway epithelium: more than just a structural barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Analysis of chemoresistance in lung cancer with a simple microfluidic device

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

High throughput determination of TGFβ1/SMAD3 targets in A549 lung epithelial cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Acoustically detectable cellular-level lung injury induced by fluid mechanical stresses in microfluidic airway systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Epithelium damage and protection during reopening of occluded airways in a physiologic microfluidic pulmonary airway model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Application of a microfluidic chip-based 3D co-culture to test drug sensitivity for individualized treatment of lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Cells, tissues, and organs on chips: challenges and opportunities for the cancer tumor microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Microfluidic chip: next-generation platform for systems biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Functional characterization of circulating tumor cells with a prostate-cancer-specific microfluidic device

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Tumors on chips: oncology meets microfluidics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Lab-on-a-chip technologies for oral-based cancer screening and diagnostics: capabilities, issues, and prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

A microfluidic system for investigation of extravascular transport and cellular uptake of drugs in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

On-chip anticancer drug test of regular tumor spheroids formed in microwells by a distributive microchannel network

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

A radial microfluidic concentration gradient generator with high-density channels for cell apoptosis assay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Development of a novel microRNA promoter microarray for ChIP-on-chip assay to identify epigenetically regulated microRNAs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Lab-on-a-Chip for anticancer drug screening using quantum dots probe based apoptosis assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Dense type I collagen matrices that support cellular remodeling and microfabrication for studies of tumor angiogenesis and vasculogenesis in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Cell migration into scaffolds under co-culture conditions in a microfluidic platform.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Breast on-a-chip: mimicry of the channeling system of the breast for development of theranostics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Thick-tissue bioreactor as a platform for long-term organotypic culture and drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Microscale 3-D hydrogel scaffold for biomimetic gastrointestinal (GI) tract model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

NutriChip: nutrition analysis meets microfluidics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Physical cues of biomaterials guide stem cell differentiation fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Dielectrophoretically aligned carbon nanotubes to control electrical and mechanical properties of hydrogels to fabricate contractile muscle myofibers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Proliferation and skeletal myotube formation capability of C2C12 and H9c2 cells on isotropic and anisotropic electrospun nanofibrous PHB scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Performance of novel kidney biomarkers in preclinical toxicity studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Muscle on a chip: in vitro contractility assays for smooth and striated muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

The role of body-on-a-chip devices in drug and toxicity studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Metabolic control through hepatocyte and adipose tissue cross-talk in a multicompartmental modular bioreactor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Glucose and fatty acid metabolism in a 3 tissue in-vitro model challenged with normo- and hyperglycaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

A micro cell culture analog (microCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Towards a human-on-chip: culturing multiple cell types on a chip with compartmentalized microenvironments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Workshop meeting report Organs-on-Chips: human disease models

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Induced pluripotent stem cells: the new patient?

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Microfabricated mammalian organ systems and their integration into models of whole animals and humans

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

PDMS absorption of small molecules and consequences in microfluidic applications.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Recent developments in PDMS surface modification for microfluidic devices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Grafting epoxy-modified hydrophilic polymers onto poly(dimethylsiloxane) microfluidic chip to resist nonspecific protein adsorption.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Engineering challenges for instrumenting and controlling integrated organ-on-chip systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

An inertia enhanced passive pumping mechanism for fluid flow in microfluidic devices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

On being the right size: scaling effects in designing a human-on-a-chip.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Cell culture monitoring for drug screening and cancer research: a transparent, microfluidic, multi-sensor microsystem

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Fluorescence optical detection in situ for real-time monitoring of cytochrome P450 enzymatic activity of liver cells in multiple microfluidic devices

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Translating induced pluripotent stem cells from bench to bedside: application to retinal diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

An algorithm-based topographical biomaterials library to instruct cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

Construction of a Biomimetic Surface on Microfluidic Chips for Biofouling Resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

An update on metabolism studies using human hepatocytes in primary culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2014.886562

10.1517/17460441.2014.886562

21 January 2018

Identifiers

DOI

1 reference

30 August 2017

1 reference