(Q38218964)

31 August 2017

title

Transcriptional outcome of telomere signalling (English)

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31 August 2017

Jing Ye

1

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31 August 2017

Valérie M Renault

series ordinal

2

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31 August 2017

Karine Jamet

series ordinal

3

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31 August 2017

Eric Gilson

series ordinal

4

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31 August 2017

publication date

10 June 2014

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31 August 2017

published in

Nature Reviews Genetics

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31 August 2017

volume

15

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31 August 2017

issue

7

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31 August 2017

page(s)

491-503

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https://scigraph.springernature.com/pub.10.1038/nrg3743

31 August 2017

exact match

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cites work

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Rif1 and Rif2 shape telomere function and architecture through multivalent Rap1 interactions

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TRF2 promotes, remodels and protects telomeric Holliday junctions

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The N-terminal domains of TRF1 and TRF2 regulate their ability to condense telomeric DNA.

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Human Rap1 interacts directly with telomeric DNA and regulates TRF2 localization at the telomere

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Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing

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Role of TRF2 in the assembly of telomeric chromatin.

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TRF2 controls telomeric nucleosome organization in a cell cycle phase-dependent manner

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1 reference

TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs

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1 reference

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.

21 January 2018

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TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres

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A chromatin-mediated mechanism for specification of conditional transcription factor targets

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Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

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PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis

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IKK-beta links inflammation to obesity-induced insulin resistance

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Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging

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Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal

21 January 2018

1 reference

TRF2 is in neuroglial cytoplasm and induces neurite-like processes

21 January 2018

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Telomere protection mechanisms change during neurogenesis and neuronal maturation: newly generated neurons are hypersensitive to telomere and DNA damage

21 January 2018

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The identification of zebrafish mutants showing alterations in senescence-associated biomarkers

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TRF2 dysfunction elicits DNA damage responses associated with senescence in proliferating neural cells and differentiation of neurons.

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Nontelomeric splice variant of telomere repeat-binding factor 2 maintains neuronal traits by sequestering repressor element 1-silencing transcription factor

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FoxO3 regulates neural stem cell homeostasis

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TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program

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Telomerase modulates Wnt signalling by association with target gene chromatin

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Alternatively spliced telomerase reverse transcriptase variants lacking telomerase activity stimulate cell proliferation

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Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase

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Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase

21 January 2018

1 reference

Telomeres, a busy platform for cell signaling.

21 January 2018

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An investigation of the effects of the core protein telomerase reverse transcriptase on Wnt signaling in breast cancer cells

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Telomerase directly regulates NF-κB-dependent transcription.

21 January 2018

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NF-kappa B regulates transcription of the mouse telomerase catalytic subunit

21 January 2018

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Human telomerase reverse transcriptase regulates MMP expression independently of telomerase activity via NF-κB-dependent transcription

21 January 2018

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Post-translational modifications of TRF1 and TRF2 and their roles in telomere maintenance.

21 January 2018

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Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

21 January 2018

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Functional subdomain in the ankyrin domain of tankyrase 1 required for poly(ADP-ribosyl)ation of TRF1 and telomere elongation

21 January 2018

1 reference

TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres

21 January 2018

1 reference

Functional interaction between poly(ADP-Ribose) polymerase 2 (PARP-2) and TRF2: PARP activity negatively regulates TRF2.

21 January 2018

1 reference

PARP1 Is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres

21 January 2018

1 reference

Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence.

21 January 2018

1 reference

p300-mediated acetylation of TRF2 is required for maintaining functional telomeres

21 January 2018

1 reference

Mammalian telomeres end in a large duplex loop

21 January 2018

1 reference

SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast

21 January 2018

1 reference

A methyltransferase targeting assay reveals silencer-telomere interactions in budding yeast

21 January 2018

1 reference

Chromosome looping in yeast: telomere pairing and coordinated movement reflect anchoring efficiency and territorial organization

21 January 2018

1 reference

Homologous recombination generates T-loop-sized deletions at human telomeres

21 January 2018

1 reference

ERCC1/XPF protects short telomeres from homologous recombination in Arabidopsis thaliana

21 January 2018

1 reference

Cohabitation of insulators and silencing elements in yeast subtelomeric regions

21 January 2018

1 reference

A telomere-binding protein (TRF2/MTBP) from mouse nuclear matrix with motives of an intermediate filament-type rod domain

21 January 2018

1 reference

Identification of a perinuclear positioning element in human subtelomeres that requires A-type lamins and CTCF.

21 January 2018

1 reference

Human telomeres are tethered to the nuclear envelope during postmitotic nuclear assembly.

21 January 2018

1 reference

RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae.

21 January 2018

1 reference

Telomere folding is required for the stable maintenance of telomere position effects in yeast

21 January 2018

1 reference

A haploid-specific transcriptional response to irradiation in Saccharomyces cerevisiae

21 January 2018

1 reference

Clustering heterochromatin: Sir3 promotes telomere clustering independently of silencing in yeast

21 January 2018

1 reference

Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres

21 January 2018

1 reference

Ku-deficient yeast strains exhibit alternative states of silencing competence

21 January 2018

1 reference

Telomere position effect in human cells

21 January 2018

1 reference

Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres

21 January 2018

1 reference

Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1α.

21 January 2018

1 reference

Telomere position effect regulates DUX4 in human facioscapulohumeral muscular dystrophy

21 January 2018

1 reference

Telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations

21 January 2018

1 reference

SIRT6 is required for maintenance of telomere position effect in human cells

21 January 2018

1 reference

Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity

21 January 2018

1 reference

The heterochromatin protein 1 prevents telomere fusions in Drosophila

21 January 2018

1 reference

Methylated TRF2 associates with the nuclear matrix and serves as a potential biomarker for cellular senescence.

21 January 2018

1 reference

Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage.

21 January 2018

1 reference

Short telomeres compromise β-cell signaling and survival

21 January 2018

1 reference

DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion

21 January 2018

1 reference

Linking functional decline of telomeres, mitochondria and stem cells during ageing

21 January 2018

1 reference

Telomere length and type 2 diabetes in males, a premature aging syndrome.

21 January 2018

1 reference

Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins

21 January 2018

1 reference

Telomere-binding protein Taz1 controls global replication timing through its localization near late replication origins in fission yeast

21 January 2018

1 reference

Protein phosphatase 1 recruitment by Rif1 regulates DNA replication origin firing by counteracting DDK activity

21 January 2018

1 reference

Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex

21 January 2018

1 reference

Mitochondrial localization of telomeric protein TIN2 links telomere regulation to metabolic control

21 January 2018

1 reference

The major reverse transcriptase-incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosis

21 January 2018

1 reference

Telomeric RNAs mark sex chromosomes in stem cells.

21 January 2018

1 reference

Telomere looping permits gene activation by a downstream UAS in yeast

21 January 2018

1 reference

RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability

21 January 2018

1 reference

Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

31 March 2020

1 reference

Evidence for silencing compartments within the yeast nucleus: a role for telomere proximity and Sir protein concentration in silencer-mediated repression

31 March 2020

1 reference

Silencing of genes at nontelomeric sites in yeast is controlled by sequestration of silencing factors at telomeres by Rap 1 protein

31 March 2020

1 reference

Identification of human Rap1: implications for telomere evolution

31 March 2020

1 reference

Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells

31 March 2020

1 reference

TRF2-mediated stabilization of hREST4 is critical for the differentiation and maintenance of neural progenitors.

31 March 2020

1 reference

Human telomeres are attached to the nuclear matrix

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24913665

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRG3743

1 reference

Dimensions Publication ID

31 August 2017

1015315311

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