(Q38239281)

31 August 2017

title

FcRn: from molecular interactions to regulation of IgG pharmacokinetics and functions (English)

1 reference

31 August 2017

1 reference

molecular interaction

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25116104%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

2

Ramraj Velmurugan

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25116104%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

4

E Sally Ward

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25116104%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

author name string

Dilip K Challa

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25116104%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

publication date

1 January 2014

1 reference

Current Topics in Microbiology and Immunology

31 August 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25116104%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

volume

382

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25116104%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

page(s)

249-272

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25116104%20AND%20SRC:MED&resulttype=core&format=json

Astrocyte-endothelial interactions at the blood-brain barrier

2 June 2020

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31 March 2020

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Rab GTPases as regulators of endocytosis, targets of disease and therapeutic opportunities

31 March 2020

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Neonatal FcR expression in bone marrow-derived cells functions to protect serum IgG from catabolism

31 March 2020

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Podocytes use FcRn to clear IgG from the glomerular basement membrane

31 March 2020

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The conserved histidine 166 residue of the human neonatal Fc receptor heavy chain is critical for the pH-dependent binding to albumin.

31 March 2020

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Anti-carcinoembryonic antigen single-chain variable fragment antibody variants bind mouse and human neonatal Fc receptor with different affinities that reveal distinct cross-species differences in serum half-life

31 March 2020

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Expression of functionally active FcRn and the differentiated bidirectional transport of IgG in human placental endothelial cells

31 March 2020

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Transmission of immunoglobulin to foetal and neonatal mice

31 March 2020

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CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens.

31 March 2020

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Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells

31 March 2020

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Functional expression of the MHC class I-related receptor, FcRn, in endothelial cells of mice.

31 March 2020

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Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen

31 March 2020

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Expression of FcRn, the MHC class I-related receptor for IgG, in human keratinocytes

31 March 2020

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Autoantibody depletion ameliorates disease in murine experimental autoimmune encephalomyelitis

31 March 2020

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Therapeutic antibodies for autoimmunity and inflammation

31 March 2020

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The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan

31 March 2020

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Monoclonal antibodies directed against human FcRn and their applications.

31 March 2020

1 reference

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The MHC class I related Fc receptor, FcRn, is expressed in the epithelial cells of the human mammary gland.

31 March 2020

1 reference

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Bidirectional transepithelial IgG transport by a strongly polarized basolateral membrane Fcgamma-receptor.

31 March 2020

1 reference

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Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Antibody-mediated organ-allograft rejection

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Myasthenia gravis: past, present, and future

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Efflux of monoclonal antibodies from rat brain by neonatal Fc receptor, FcRn

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Increasing the affinity of a human IgG1 for the neonatal Fc receptor: biological consequences.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn).

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Ca2+-dependent calmodulin binding to FcRn affects immunoglobulin G transport in the transcytotic pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of gamma-globulin in humans

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Using multifocal plane microscopy to reveal novel trafficking processes in the recycling pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Analyses of the recycling receptor, FcRn, in live cells reveal novel pathways for lysosomal delivery.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Investigation of the influence of FcRn on the distribution of IgG to the brain

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Pharmacokinetic effects of 4C9, an anti-FcRn antibody, in rats: implications for the use of FcRn inhibitors for the treatment of humoral autoimmune and alloimmune conditions

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Increasing the serum persistence of an IgG fragment by random mutagenesis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

The function of Fcγ receptors in dendritic cells and macrophages

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

The Neonatal Fc receptor (FcRn) enhances human immunodeficiency virus type 1 (HIV-1) transcytosis across epithelial cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Walking to work: roles for class V myosins as cargo transporters

31 March 2020

1 reference

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Plasma exchange versus intravenous immunoglobulin for myasthenia gravis crisis: an acute hospital cost comparison study

31 March 2020

1 reference

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Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity

31 March 2020

1 reference

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Engineered human IgG antibodies with longer serum half-lives in primates

31 March 2020

1 reference

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An engineered human IgG1 antibody with longer serum half-life.

31 March 2020

1 reference

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Fc receptor-targeted therapies for the treatment of inflammation, cancer and beyond

31 March 2020

1 reference

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Phagosomes are competent organelles for antigen cross-presentation

31 March 2020

1 reference

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Expression of the neonatal Fc receptor, FcRn, on human intestinal epithelial cells

31 March 2020

1 reference

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Increased clearance of IgG in mice that lack beta 2-microglobulin: possible protective role of FcRn

31 March 2020

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31 March 2020

1 reference

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AQP4 antibodies in neuromyelitis optica: diagnostic and pathogenetic relevance

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Immunology of the human genital tract

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

The mechanism of intestinal uptake and transcellular transport of IgG in the neonatal rat

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Mapping of the neonatal Fc receptor in the rodent eye.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Mapping the site on human IgG for binding of the MHC class I-related receptor, FcRn

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

FcRn-mediated transcytosis of immunoglobulin G in human renal proximal tubular epithelial cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Neonatal Fc receptor: from immunity to therapeutics

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

N-Glycan Moieties in Neonatal Fc Receptor Determine Steady-state Membrane Distribution and Directional Transport of IgG.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Cross-priming in health and disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Transfer of IgG in the female genital tract by MHC class I-related neonatal Fc receptor (FcRn) confers protective immunity to vaginal infection

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Amelioration of experimental autoimmune myasthenia gravis in rats by neonatal FcR blockade

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Activation of the JAK/STAT-1 signaling pathway by IFN-gamma can down-regulate functional expression of the MHC class I-related neonatal Fc receptor for IgG.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

NF-kappaB signaling regulates functional expression of the MHC class I-related neonatal Fc receptor for IgG via intronic binding sequences.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Antibody immunosuppressive therapy in solid-organ transplant: Part I.

31 March 2020

1 reference

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Ontogenetic development and distribution of antibody transport and Fc receptor mRNA expression in rat intestine

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Inside the mucosal immune system

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Localization of the site of the IgG molecule that regulates maternofetal transmission in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

PEGylation enhances the therapeutic potential of peptide antagonists of the neonatal Fc receptor, FcRn

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Mosaic organization of the endocytic pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

The role of autoantibodies in autoimmune disease

31 March 2020

1 reference

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Towards a systems understanding of MHC class I and MHC class II antigen presentation.

31 March 2020

1 reference

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Characterization of basolateral-targeting signals in the neonatal Fc receptor

31 March 2020

1 reference

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Fcgamma receptors as regulators of immune responses

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Use of intravenous immunoglobulin in human disease: a review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Neonatal Fc receptor blockade by Fc engineering ameliorates arthritis in a murine model

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Cell biology of the glomerular podocyte

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Pathology of demyelinating diseases

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

The stoichiometry and affinity of the interaction of murine Fc fragments with the MHC class I-related receptor, FcRn

31 March 2020

1 reference

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Expression of neonatal Fc receptor in the eye.

31 March 2020

1 reference

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Elucidation of intracellular recycling pathways leading to exocytosis of the Fc receptor, FcRn, by using multifocal plane microscopy

31 March 2020

1 reference

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Dependence of antibody-mediated presentation of antigen on FcRn

31 March 2020

1 reference

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Analysis of the pH dependence of the neonatal Fc receptor/immunoglobulin G interaction using antibody and receptor variants.

31 March 2020

1 reference

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The class I major histocompatibility complex related Fc receptor shows pH-dependent stability differences correlating with immunoglobulin binding and release

31 March 2020

1 reference

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Which are the antibodies to watch in 2013?

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Receptor-mediated transport of IgG

31 March 2020

1 reference

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FcRn: the neonatal Fc receptor comes of age.

31 March 2020

1 reference

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The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs

31 March 2020

1 reference

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The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: retrieval is disrupted in nephrotic states

31 March 2020

1 reference

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Serum immunoglobulin levels in normal, premature and postmature newborns and their mothers

31 March 2020

1 reference

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Stoichiometry of the interaction between the major histocompatibility complex-related Fc receptor and its Fc ligand

31 March 2020

1 reference

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Renal FcRn reclaims albumin but facilitates elimination of IgG.

31 March 2020

1 reference

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Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier

31 March 2020

1 reference

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Sedimentation equilibrium analysis of recombinant mouse FcRn with murine IgG1.

31 March 2020

1 reference

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Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Antibody therapy of cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Autoantibody explosion in systemic lupus erythematosus: more than 100 different antibodies found in SLE patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

An Fc receptor structurally related to MHC class I antigens

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

An IgG-transporting Fc receptor expressed in the syncytiotrophoblast of human placenta

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Type I IFN drives a distinctive dendritic cell maturation phenotype that allows continued class II MHC synthesis and antigen processing

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Rab GTPases as coordinators of vesicle traffic

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Ligand valency affects transcytosis, recycling and intracellular trafficking mediated by the neonatal Fc receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

The neonatal Fc receptor is expressed by human lymphocytes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

The half-lives of serum immunoglobulins in adult mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Monoclonal antibody pharmacokinetics and pharmacodynamics

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

From sorting endosomes to exocytosis: association of Rab4 and Rab11 GTPases with the Fc receptor, FcRn, during recycling.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Chapter 4: Multitasking by exploitation of intracellular transport functions the many faces of FcRn.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Cost-minimization analysis of the direct costs of TPE and IVIg in the treatment of Guillain-Barré syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

31 March 2020

Mucosal immunoglobulins

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

The MHC class II-associated invariant chain interacts with the neonatal Fc gamma receptor and modulates its trafficking to endosomal/lysosomal compartments

31 March 2020

1 reference

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Engineering human IgG1 affinity to human neonatal Fc receptor: impact of affinity improvement on pharmacokinetics in primates

31 March 2020

1 reference

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Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells.

31 March 2020

1 reference

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Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria

31 March 2020

1 reference

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Enhanced antibody half-life improves in vivo activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

Mediated efflux of IgG molecules from brain to blood across the blood-brain barrier.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-07911-0_12