(Q38260571)

1 September 2017

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title

Phagocytosis: receptors, signal integration, and the cytoskeleton (English)

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1 September 2017

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2

Sergio Grinstein

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1 September 2017

Spencer A Freeman

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PubMed ID

25319336

1 September 2017

language of work or name

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1 November 2014

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1 September 2017

23

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based on heuristic

inferred from page(s)

published in

Immunological Reviews

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1 September 2017

262

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1 September 2017

1

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1 September 2017

193-215

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B cell follicles and antigen encounters of the third kind

1 September 2017

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Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells.

21 January 2018

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Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells

21 January 2018

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CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens.

21 January 2018

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The M1 and M2 paradigm of macrophage activation: time for reassessment

21 January 2018

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Exploring the full spectrum of macrophage activation

21 January 2018

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Modulation of macrophage phenotype by cell shape

21 January 2018

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12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance

21 January 2018

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Regulation from within: the cytoskeleton in transmembrane signaling

21 January 2018

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Receptor mobility, the cytoskeleton, and particle binding during phagocytosis

21 January 2018

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Phagocytosis of microbes: complexity in action

21 January 2018

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Human Fc gamma RII, in the absence of other Fc gamma receptors, mediates a phagocytic signal

21 January 2018

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Immune recognition. A new receptor for beta-glucans

21 January 2018

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The phosphatidylserine receptor TIM-4 does not mediate direct signaling

21 January 2018

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The phosphatidylserine receptor TIM4 utilizes integrins as coreceptors to effect phagocytosis

21 January 2018

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Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells

21 January 2018

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Epithelial cells as phagocytes: apoptotic epithelial cells are engulfed by mammary alveolar epithelial cells and repress inflammatory mediator release

21 January 2018

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Information processing during phagocytosis

21 January 2018

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Role of target geometry in phagocytosis

21 January 2018

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Shaping cups into phagosomes and macropinosomes

21 January 2018

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A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages

21 January 2018

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A requirement for phosphatidylinositol 3-kinase in pseudopod extension

21 January 2018

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Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses.

21 January 2018

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Novel roles for the IgG Fc glycan

21 January 2018

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Fc-receptors as regulators of immunity.

21 January 2018

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The cell biology of phagocytosis

21 January 2018

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FcgammaRIIB in autoimmunity and infection: evolutionary and therapeutic implications.

21 January 2018

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Modulation of immune complex-induced inflammation in vivo by the coordinate expression of activation and inhibitory Fc receptors.

21 January 2018

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Inhibitory Fcγ receptor is required for the maintenance of tolerance through distinct mechanisms

21 January 2018

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Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway.

21 January 2018

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Signalling through C-type lectin receptors: shaping immune responses

21 January 2018

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Signalling C-type lectin receptors, microbial recognition and immunity.

21 January 2018

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Human dectin-1 deficiency and mucocutaneous fungal infections

21 January 2018

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Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments.

21 January 2018

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Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'.

21 January 2018

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Immune recognition of Candida albicans beta-glucan by dectin-1.

21 January 2018

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C-type lectin receptors orchestrate antifungal immunity

21 January 2018

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The immunological synapse: a molecular machine controlling T cell activation

21 January 2018

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Integrins: bidirectional, allosteric signaling machines

21 January 2018

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Integrin ligands at a glance

21 January 2018

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CR3 (CD11b/CD18) and CR4 (CD11c/CD18) are involved in complement-independent antibody-mediated phagocytosis of Cryptococcus neoformans

21 January 2018

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Complement receptor 3 (CD11b/CD18) mediates type I and type II phagocytosis during nonopsonic and opsonic phagocytosis, respectively

21 January 2018

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Complement-dependent clearance of apoptotic cells by human macrophages

21 January 2018

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Identification of a factor that links apoptotic cells to phagocytes

21 January 2018

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Expression of developmental endothelial locus-1 in a subset of macrophages for engulfment of apoptotic cells

21 January 2018

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Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

21 January 2018

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Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX

21 January 2018

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A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus

21 January 2018

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Requirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2.

21 January 2018

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Structure of an integrin with an αI domain, complement receptor type 4

21 January 2018

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The final steps of integrin activation: the end game

21 January 2018

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Structural basis of integrin regulation and signaling

21 January 2018

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Integrin-dependent phagocytosis: spreading from microadhesion to new concepts

21 January 2018

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Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis.

21 January 2018

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Activation of a signaling cascade by cytoskeleton stretch

21 January 2018

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Mechanical dynamics of single cells during early apoptosis

21 January 2018

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Measuring the stiffness of bacterial cells from growth rates in hydrogels of tunable elasticity.

21 January 2018

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The bacterial cytoplasm has glass-like properties and is fluidized by metabolic activity

21 January 2018

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Scavenger receptors in homeostasis and immunity

21 January 2018

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Multimolecular signaling complexes enable Syk-mediated signaling of CD36 internalization

21 January 2018

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CD36 and TLR interactions in inflammation and phagocytosis: implications for malaria

21 January 2018

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Dynamic organizing principles of the plasma membrane that regulate signal transduction: commemorating the fortieth anniversary of Singer and Nicolson's fluid-mosaic model.

21 January 2018

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Phospholipids undergo hop diffusion in compartmentalized cell membrane

21 January 2018

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The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor

21 January 2018

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TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation.

21 January 2018

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Cytoskeletal control of CD36 diffusion promotes its receptor and signaling function

21 January 2018

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Plasma membrane-associated proteins are clustered into islands attached to the cytoskeleton

21 January 2018

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Actin restricts FcepsilonRI diffusion and facilitates antigen-induced receptor immobilization

21 January 2018

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Observing FcepsilonRI signaling from the inside of the mast cell membrane

21 January 2018

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Increased sensitivity of antigen-experienced T cells through the enrichment of oligomeric T cell receptor complexes.

21 January 2018

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Microdomains of the C-type lectin DC-SIGN are portals for virus entry into dendritic cells

21 January 2018

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Fcgamma-receptors induce Mac-1 (CD11b/CD18) mobilization and accumulation in the phagocytic cup for optimal phagocytosis

21 January 2018

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Src-family and Syk kinases in activating and inhibitory pathways in innate immune cells: signaling cross talk

21 January 2018

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The ins and outs of leukocyte integrin signaling

21 January 2018

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Sequence and domain structure of talin

21 January 2018

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The tail of integrins, talin, and kindlins

21 January 2018

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Structural basis of integrin activation by talin

21 January 2018

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The phosphotyrosine binding-like domain of talin activates integrins

21 January 2018

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An essential role for talin during alpha(M)beta(2)-mediated phagocytosis

21 January 2018

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Regulator of G-Protein Signalling-14 (RGS14) Regulates the Activation of αMβ2 Integrin during Phagocytosis

21 January 2018

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Rap1 controls activation of the α(M)β(2) integrin in a talin-dependent manner

21 January 2018

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Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b

21 January 2018

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Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation

21 January 2018

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The mechanism of kindlin-mediated activation of integrin αIIbβ3.

21 January 2018

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The GTPase Rap1 controls functional activation of macrophage integrin alphaMbeta2 by LPS and other inflammatory mediators

21 January 2018

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Regulating Rap small G-proteins in time and space

21 January 2018

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Localized diacylglycerol-dependent stimulation of Ras and Rap1 during phagocytosis.

21 January 2018

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Lipopolysaccharide-induced activation of beta2-integrin function in macrophages requires Irak kinase activity, p38 mitogen- activated protein kinase, and the Rap1 GTPase

21 January 2018

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TLR signaling paralyzes monocyte chemotaxis through synergized effects of p38 MAPK and global Rap-1 activation

21 January 2018

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Lipopolysaccharide stimulates Epac1-mediated Rap1/NF-kappaB pathway in Raw 264.7 murine macrophages

21 January 2018

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Dynamic macrophage "probing" is required for the efficient capture of phagocytic targets

21 January 2018

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Actin cytoskeleton reorganization by Syk regulates Fcγ receptor responsiveness by increasing its lateral mobility and clustering

21 January 2018

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Cytoskeletal regulation couples LFA-1 conformational changes to receptor lateral mobility and clustering

21 January 2018

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Membrane ruffles capture C3bi-opsonized particles in activated macrophages

21 January 2018

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Filopodia act as phagocytic tentacles and pull with discrete steps and a load-dependent velocity.

21 January 2018

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A WAVE2-Abi1 complex mediates CSF-1-induced F-actin-rich membrane protrusions and migration in macrophages

21 January 2018

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Microbial manipulation of receptor crosstalk in innate immunity

21 January 2018

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Identification of Tim4 as a phosphatidylserine receptor

21 January 2018

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TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.

21 January 2018

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Two-step engulfment of apoptotic cells

21 January 2018

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CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

21 January 2018

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Syk is required for integrin signaling in neutrophils

21 January 2018

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A nucleator arms race: cellular control of actin assembly

21 January 2018

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Spire-type actin nucleators cooperate with Formin-2 to drive asymmetric oocyte division

21 January 2018

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Dia-interacting protein modulates formin-mediated actin assembly at the cell cortex.

21 January 2018

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Unleashing formins to remodel the actin and microtubule cytoskeletons

21 January 2018

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Role of formins in actin assembly: nucleation and barbed-end association

21 January 2018

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Formin Leaky Cap Allows Elongation in the Presence of Tight Capping Proteins

21 January 2018

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The formin FRL1 (FMNL1) is an essential component of macrophage podosomes

21 January 2018

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Arp2/3 complex is bound and activated by two WASP proteins

21 January 2018

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Structural and biochemical characterization of two binding sites for nucleation-promoting factor WASp-VCA on Arp2/3 complex

21 January 2018

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Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome

21 January 2018

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Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate

21 January 2018

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The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly

21 January 2018

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Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex

21 January 2018

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Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex

21 January 2018

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Contributions of Wiskott-Aldrich syndrome family cytoskeletal regulatory adapters to immune regulation

21 January 2018

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Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages

21 January 2018

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The F-BAR protein PSTPIP1 controls extracellular matrix degradation and filopodia formation in macrophages

21 January 2018

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Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck

21 January 2018

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WAVE regulatory complex activation by cooperating GTPases Arf and Rac1

21 January 2018

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Structure and control of the actin regulatory WAVE complex

21 January 2018

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The WASP-WAVE protein network: connecting the membrane to the cytoskeleton

21 January 2018

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The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton

21 January 2018

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Local F-actin network links synapse formation and axon branching

21 January 2018

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Physical mechanisms of signal integration by WASP family proteins.

21 January 2018

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Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex

21 January 2018

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FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling

21 January 2018

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Coordination of Rho GTPase activities during cell protrusion

21 January 2018

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Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior

21 January 2018

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Coronin-1 function is required for phagosome formation

21 January 2018

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Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers

21 January 2018

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Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge

21 January 2018

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Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway

21 January 2018

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Chemotaxis and phagocytosis in neutrophils is independent of coronin 1.

21 January 2018

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RNA interference in J774 macrophages reveals a role for coronin 1 in mycobacterial trafficking but not in actin-dependent processes

21 January 2018

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GMF is a cofilin homolog that binds Arp2/3 complex to stimulate filament debranching and inhibit actin nucleation

21 January 2018

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Gelsolin: the tail of a molecular gymnast

21 January 2018

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Functions of cofilin in cell locomotion and invasion.

21 January 2018

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Quantitative morphological signatures define local signaling networks regulating cell morphology.

21 January 2018

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Control of actin filament treadmilling in cell motility

21 January 2018

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Reconstitution of actin-based motility of Listeria and Shigella using pure proteins

21 January 2018

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Proteins of the ADF/cofilin family: essential regulators of actin dynamics

21 January 2018

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Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation

21 January 2018

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A role for cofilin and LIM kinase in Listeria-induced phagocytosis

21 January 2018

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A systems biology analysis of the Drosophila phagosome

21 January 2018

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Antisense oligonucleotide to cofilin enhances respiratory burst and phagocytosis in opsonized zymosan-stimulated mouse macrophage J774.1 cells.

21 January 2018

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PTEN directly activates the actin depolymerization factor cofilin-1 during PGE2-mediated inhibition of phagocytosis of fungi

21 January 2018

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Immunological responses and actin dynamics in macrophages are controlled by N-cofilin but are independent from ADF

21 January 2018

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Rho-kinase and myosin-II control phagocytic cup formation during CR, but not FcgammaR, phagocytosis

21 January 2018

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Cdc42 regulates Fc gamma receptor-mediated phagocytosis through the activation and phosphorylation of Wiskott-Aldrich syndrome protein (WASP) and neural-WASP.

21 January 2018

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Wiskott-Aldrich syndrome protein is a key regulator of the phagocytic cup formation in macrophages

21 January 2018

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Phase transitions in the assembly of multivalent signalling proteins

21 January 2018

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Cross-linker dynamics determine the mechanical properties of actin gels

21 January 2018

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Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis

21 January 2018

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FBP17 Mediates a Common Molecular Step in the Formation of Podosomes and Phagocytic Cups in Macrophages

21 January 2018

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Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells

21 January 2018

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Tyrosine phosphorylation of Wiskott-Aldrich syndrome protein (WASP) by Hck regulates macrophage function

21 January 2018

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Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein

21 January 2018

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Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes

21 January 2018

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Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases

21 January 2018

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A requirement for ARF6 in Fcgamma receptor-mediated phagocytosis in macrophages

21 January 2018

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Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages

21 January 2018

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ADP ribosylation factor 6 is activated and controls membrane delivery during phagocytosis in macrophages

21 January 2018

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Ena/VASP: towards resolving a pointed controversy at the barbed end

21 January 2018

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beta1 and beta2 integrins activate different signalling pathways in monocytes

21 January 2018

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Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

21 January 2018

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The Syk protein tyrosine kinase is essential for Fcgamma receptor signaling in macrophages and neutrophils

21 January 2018

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A role for mammalian diaphanous-related formins in complement receptor (CR3)-mediated phagocytosis in macrophages

21 January 2018

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21 January 2018

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Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis

21 January 2018

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Cofilin-mediated F-actin severing is regulated by the Rap GTPase and controls the cytoskeletal dynamics that drive lymphocyte spreading and BCR microcluster formation.

21 January 2018

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RhoG is required for both FcγR- and CR3-mediated phagocytosis

21 January 2018

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The motor protein myosin 1G functions in FcγR-mediated phagocytosis

21 January 2018

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Phosphoinositide-3-kinase-independent contractile activities associated with Fcgamma-receptor-mediated phagocytosis and macropinocytosis in macrophages

21 January 2018

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Intracellular fluid flow in rapidly moving cells.

21 January 2018

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The NF-κB signaling protein Bcl10 regulates actin dynamics by controlling AP1 and OCRL-bearing vesicles

21 January 2018

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A Cdc42 activation cycle coordinated by PI 3-kinase during Fc receptor-mediated phagocytosis

21 January 2018

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Cdc42, Rac1, and Rac2 display distinct patterns of activation during phagocytosis.

21 January 2018

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Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway

21 January 2018

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Phagocytosis mediated by three distinct Fc gamma receptor classes on human leukocytes

21 January 2018

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Complement receptor 1/CD35 is a receptor for mannan-binding lectin

21 January 2018

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A molecular basis for integrin alphaMbeta 2 ligand binding promiscuity

21 January 2018

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CD11c/CD18 on neutrophils recognizes a domain at the N terminus of the A alpha chain of fibrinogen

21 January 2018

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The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.

21 January 2018

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Affinity of integrins for damaged extracellular matrix: alpha v beta 3 binds to denatured collagen type I through RGD sites

21 January 2018

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Dectin-1 is a major beta-glucan receptor on macrophages

21 January 2018

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Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells

21 January 2018

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Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria

21 January 2018

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CD36 mediates the phagocytosis of Plasmodium falciparum-infected erythrocytes by rodent macrophages

21 January 2018

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Macrophage class A scavenger receptor-mediated phagocytosis of Escherichia coli: role of cell heterogeneity, microbial strain, and culture conditions in vitro

21 January 2018

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Protection from lethal gram-positive infection by macrophage scavenger receptor-dependent phagocytosis

21 January 2018

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BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module

21 January 2018

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Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor

21 January 2018

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Cutting edge: mouse CD300f (CMRF-35-like molecule-1) recognizes outer membrane-exposed phosphatidylserine and can promote phagocytosis

21 January 2018

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Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases

21 January 2018

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Serum-derived protein S binds to phosphatidylserine and stimulates the phagocytosis of apoptotic cells

21 January 2018

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Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte

21 January 2018

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alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells

21 January 2018

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Oxidized phosphatidylserine-CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cells

21 January 2018

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The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity

21 January 2018

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Nck and Cdc42 co-operate to recruit N-WASP to promote FcγR-mediated phagocytosis

21 January 2018

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Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity

21 January 2018

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Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis

21 January 2018

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Control of cytoplasmic actin gel–sol transformation by gelsolin, a calcium-dependent regulatory protein

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/IMR.12212

1 reference

1 September 2017

1 reference

PubMed ID

25319336