(Q38265601)

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Sustained Action of Ceramide on the Insulin Signaling Pathway in Muscle Cells: IMPLICATION OF THE DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE

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3 March 2020

Sustained Action of Ceramide on the Insulin Signaling Pathway in Muscle Cells: IMPLICATION OF THE DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE (English)

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3 March 2020

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Agnieszka Blachnio-Zabielska

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3 March 2020

Olivier Bourron

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3 March 2020

Fabienne Foufelle

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3 March 2020

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Rana Mahfouz

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Rima Hage Hassan

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3 March 2020

Ana Catarina Pacheco de Sousa

2

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3 March 2020

Isabelle Hainault

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3 March 2020

Fabien Koskas

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23 December 2015

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3 March 2020

Journal of Biological Chemistry

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3 March 2020

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3 March 2020

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3 March 2020

3019-3029

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3 March 2020

Targeting sphingolipid metabolism in the treatment of obesity/type 2 diabetes

1 reference

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6 September 2017

Characterising the inhibitory actions of ceramide upon insulin signaling in different skeletal muscle cell models: a mechanistic insight

1 reference

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6 September 2017

Defect of insulin signal in peripheral tissues: Important role of ceramide

1 reference

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6 September 2017

Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice.

1 reference

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6 September 2017

Protein tyrosine phosphatase 1B inhibition ameliorates palmitate-induced mitochondrial dysfunction and apoptosis in skeletal muscle cells.

1 reference

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6 September 2017

Are cultured human myotubes far from home?

1 reference

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6 September 2017

Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism.

1 reference

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6 September 2017

A liquid chromatography/tandem mass spectrometry method for measuring the in vivo incorporation of plasma free fatty acids into intramyocellular ceramides in humans

1 reference

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6 September 2017

Protection from palmitate-induced mitochondrial DNA damage prevents from mitochondrial oxidative stress, mitochondrial dysfunction, apoptosis, and impaired insulin signaling in rat L6 skeletal muscle cells

1 reference

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6 September 2017

Protein kinase C isoforms: mediators of reactive lipid metabolites in the development of insulin resistance.

1 reference

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6 September 2017

The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells

1 reference

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6 September 2017

Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742763

6 September 2017

Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis

1 reference

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6 September 2017

Plasma membrane subdomain compartmentalization contributes to distinct mechanisms of ceramide action on insulin signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742763

6 September 2017

Repression of PKR mediates palmitate-induced apoptosis in HepG2 cells through regulation of Bcl-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742763

6 September 2017

Bioactive sphingolipids: metabolism and function

1 reference

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6 September 2017

Bax signaling regulates palmitate-mediated apoptosis in C(2)C(12) myotubes

1 reference

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6 September 2017

Updating the effects of fatty acids on skeletal muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742763

6 September 2017

Principles of bioactive lipid signalling: lessons from sphingolipids

1 reference

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6 September 2017

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742763

6 September 2017

Etiology of insulin resistance

1 reference

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6 September 2017

Alteration in insulin action: role of IRS-1 serine phosphorylation in the retroregulation of insulin signalling

1 reference

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6 September 2017

Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells

1 reference

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6 September 2017

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

1 reference

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6 September 2017

Intracellular signalling mechanisms regulating glucose transport in insulin-sensitive tissues (review).

1 reference

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6 September 2017

The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742763

6 September 2017

Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

1 reference

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6 September 2017

Mechanism of interferon action: autoregulation of RNA-dependent P1/eIF-2 alpha protein kinase (PKR) expression in transfected mammalian cells

1 reference

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6 September 2017

Endoplasmic reticulum stress does not mediate palmitate-induced insulin resistance in mouse and human muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742763

6 September 2017

A role for protein kinase PKR in the mediation of Epstein-Barr virus latent membrane protein-1-induced IL-6 and IL-10 expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742763

14 September 2017

Different impacts of saturated and unsaturated free fatty acids on COX-2 expression in C(2)C(12) myotubes.

1 reference

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14 September 2017

Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742763

14 September 2017

Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742763

14 September 2017

Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption

1 reference

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27 September 2017

Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide.

1 reference

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27 September 2017

Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742763

27 September 2017

Regulation of glucose transport and glycogen synthesis in L6 muscle cells during oxidative stress. Evidence for cross-talk between the insulin and SAPK2/p38 mitogen-activated protein kinase signaling pathways

1 reference

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27 September 2017

Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells

1 reference

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27 September 2017

Potential requirement of a functional double-stranded RNA-dependent protein kinase (PKR) for the tumoricidal activation of macrophages by lipopolysaccharide or IFN-alpha beta, but not IFN-gamma.

1 reference

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27 September 2017

Modulation of double-stranded RNA-activated protein kinase in insulin sensitive tissues of obese humans.

1 reference

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23 June 2018

Targeting of PKCzeta and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide

1 reference

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23 June 2018

High levels of palmitic acid lead to insulin resistance due to changes in the level of phosphorylation of the insulin receptor and insulin receptor substrate-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742763

23 June 2018

Free fatty acid induced impairment of insulin signaling is prevented by the diastereomeric mixture of calophyllic acid and isocalophyllic acid in skeletal muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742763

31 August 2018

Double-stranded RNA-activated protein kinase is a key modulator of insulin sensitivity in physiological conditions and in obesity in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742763

31 August 2018

Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes.

1 reference

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31 August 2018

Normal growth and regenerating ability of myoblasts from unaffected muscles of facioscapulohumeral muscular dystrophy patients.

1 reference

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31 August 2018

A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4742763

31 August 2018

Serotonin (5-Hydroxytryptamine), a novel regulator of glucose transport in rat skeletal muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/26698173

12 December 2020

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10.1074/JBC.M115.686949

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3 March 2020

1 reference

Europe PubMed Central

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3 March 2020

1 reference

Europe PubMed Central

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3 March 2020

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