(Q27690875)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24936246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

title

Defect of insulin signal in peripheral tissues: Important role of ceramide (English)

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24936246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24936246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Eric Hajduch

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24936246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

author name string

Rima Hage Hassan

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24936246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

publication date

1 June 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24936246%20AND%20SRC:MED&resulttype=core&format=json

World journal of diabetes

20 March 2020

published in

2 references

Crossref

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24936246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

volume

5

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24936246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

issue

3

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24936246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

page(s)

244-257

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24936246%20AND%20SRC:MED&resulttype=core&format=json

Ceramide synthases at the centre of sphingolipid metabolism and biology

20 March 2020

cites work

1 reference

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Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome

20 March 2017

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Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism

20 March 2017

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Structural Basis of PP2A Inhibition by Small t Antigen

20 March 2017

1 reference

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

20 March 2017

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Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

20 March 2017

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Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

20 March 2017

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20 March 2017

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The PI3K-PDK1 connection: more than just a road to PKB

20 March 2017

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Mechanism of free fatty acid-induced insulin resistance in humans

20 March 2017

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The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

20 March 2017

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20 March 2017

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Economic considerations in treating patients with type 2 diabetes mellitus

29 September 2017

1 reference

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Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest

20 March 2017

1 reference

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Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

20 March 2017

1 reference

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Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes

20 March 2017

1 reference

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Protein kinase C isoforms: Multi-functional regulators of cell life and death

20 March 2017

1 reference

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Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease

20 March 2017

1 reference

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Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomains

20 March 2017

1 reference

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Mechanisms for insulin resistance: common threads and missing links

20 March 2017

1 reference

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Critical nodes in signalling pathways: insights into insulin action

7 April 2017

1 reference

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Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes

7 April 2017

1 reference

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Whole body fat: content and distribution.

7 April 2017

1 reference

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Structure, regulation, and pharmacological modulation of PP2A phosphatases

29 September 2017

1 reference

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Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasing de novo synthesis of long-chain ceramides

29 September 2017

1 reference

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Lipid in skeletal muscle myotubes is associated to the donors' insulin sensitivity and physical activity phenotypes

29 September 2017

1 reference

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Reduced skeletal muscle oxidative capacity and elevated ceramide but not diacylglycerol content in severe obesity

29 September 2017

1 reference

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Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice

29 September 2017

1 reference

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Regulation of plasma ceramide levels with fatty acid oversupply: evidence that the liver detects and secretes de novo synthesised ceramide.

29 September 2017

1 reference

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Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction.

29 September 2017

1 reference

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New insights into ER stress-induced insulin resistance.

29 September 2017

1 reference

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Sphingolipid content of human adipose tissue: relationship to adiponectin and insulin resistance.

29 September 2017

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Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance

29 September 2017

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Fenretinide prevents lipid-induced insulin resistance by blocking ceramide biosynthesis

29 September 2017

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Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects

29 September 2017

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High fat diet induced hepatic steatosis and insulin resistance: Role of dysregulated ceramide metabolism

29 September 2017

1 reference

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Chain length-specific properties of ceramides

29 September 2017

1 reference

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Sphingosine-1-phosphate signaling and its role in disease

29 September 2017

1 reference

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Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

29 September 2017

1 reference

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New insights into adipose tissue dysfunction in insulin resistance

29 September 2017

1 reference

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Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes?

29 September 2017

1 reference

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29 September 2017

1 reference

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Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance

29 September 2017

1 reference

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Promiscuous affairs of PKB/AKT isoforms in metabolism.

29 September 2017

1 reference

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Protein kinase C isoforms: mediators of reactive lipid metabolites in the development of insulin resistance.

29 September 2017

1 reference

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Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence

29 September 2017

1 reference

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Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption

29 September 2017

1 reference

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Surgical removal of omental fat does not improve insulin sensitivity and cardiovascular risk factors in obese adults

29 September 2017

1 reference

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Altered intramuscular lipid metabolism relates to diminished insulin action in men, but not women, in progression to diabetes

29 September 2017

1 reference

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Plasma membrane subdomain compartmentalization contributes to distinct mechanisms of ceramide action on insulin signaling

29 September 2017

1 reference

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Intramuscular triacylglycerol and insulin resistance: guilty as charged or wrongly accused?

29 September 2017

1 reference

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Insulin resistance is associated with higher intramyocellular triglycerides in type I but not type II myocytes concomitant with higher ceramide content

29 September 2017

1 reference

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The skinny on fat: lipolysis and fatty acid utilization in adipocytes

29 September 2017

1 reference

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Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity

29 September 2017

1 reference

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Sphingosine 1-phosphate increases glucose uptake through trans-activation of insulin receptor.

29 September 2017

1 reference

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The Randle cycle revisited: a new head for an old hat.

29 September 2017

1 reference

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Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner

29 September 2017

1 reference

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Ectopic lipids and organ function

29 September 2017

1 reference

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Bioactive sphingolipids: metabolism and function

29 September 2017

1 reference

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Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver

29 September 2017

1 reference

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Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism

29 September 2017

1 reference

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Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited

29 September 2017

1 reference

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Lipid accumulation in non-adipose tissue and lipotoxicity

29 September 2017

1 reference

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Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance.

29 September 2017

1 reference

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Sphingosine kinase 1 participates in insulin signalling and regulates glucose metabolism and homeostasis in KK/Ay diabetic mice

29 September 2017

1 reference

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Intracellular trafficking of sphingolipids: relationship to biosynthesis

29 September 2017

1 reference

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Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells

29 September 2017

1 reference

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Diabetes and obesity: the twin epidemics

29 September 2017

1 reference

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The ins and outs of sphingolipid synthesis

29 September 2017

1 reference

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Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Generation and metabolism of bioactive sphingosine-1-phosphate

29 September 2017

1 reference

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Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B.

29 September 2017

1 reference

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Divergent and convergent signaling by the diacylglycerol second messenger pathway in mammals

29 September 2017

1 reference

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Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells

29 September 2017

1 reference

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Insulin receptor substrate proteins and diabetes

29 September 2017

1 reference

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Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

The role of intramuscular lipid in insulin resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Intracellular signalling mechanisms regulating glucose transport in insulin-sensitive tissues (review).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Protein kinase B (PKB/Akt)--a key regulator of glucose transport?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Lipoprotein lipase expression exclusively in liver. A mouse model for metabolism in the neonatal period and during cachexia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsulinemia of obesity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Functions of ceramide in coordinating cellular responses to stress

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

The sphingomyelin cycle and the second messenger function of ceramide.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Enhanced sensitivity of pancreatic islets from preobese 2-week-old ob/ob mice to neurohormonal stimulation of insulin secretion

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

The fourth musketeer--from Alexandre Dumas to Claude Bernard

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Fish oil prevents insulin resistance induced by high-fat feeding in rats

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Markers of mitochondrial biogenesis and metabolism are lower in overweight and obese insulin-resistant subjects.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Ceramide content is increased in skeletal muscle from obese insulin-resistant humans

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Insulin receptor substrate 3 is not essential for growth or glucose homeostasis.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Further evidence for a central role of adipose tissue in the antihyperglycemic effect of metformin

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

The insulin signalling system and the IRS proteins

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

PDK1, one of the missing links in insulin signal transduction?

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Intramuscular triglyceride and muscle insulin sensitivity: evidence for a relationship in nondiabetic subjects.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Regulation of protein phosphatase 1 and 2A activities by insulin during myogenesis in rat skeletal muscle cells in culture.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Metabolic basis of obesity and noninsulin-dependent diabetes mellitus.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Inhibition of ceramide de novo synthesis reduces liver lipid accumulation in rats with nonalcoholic fatty liver disease

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Ceramide accumulation in L6 skeletal muscle cells due to increased activity of ceramide synthase isoforms has opposing effects on insulin action to those caused by palmitate treatment.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent-resistant membranes.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Diabetes mellitus is associated with increased intramyocellular triglyceride, but not diglyceride, content in obese humans.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Fatty acid oxidation and insulin action: when less is more

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Effect of gender on lipid-induced insulin resistance in obese subjects

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

A lipidomic analysis of nonalcoholic fatty liver disease.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Relationship between insulin sensitivity and sphingomyelin signaling pathway in human skeletal muscle

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Insulin resistance and cardiovascular disease risk factors in children of parents with the insulin resistance (metabolic) syndrome

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Elevation of ceramide in serum lipoproteins during acute phase response in humans and mice: role of serine–palmitoyl transferase

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Ceramide and reactive oxygen species generated by H2O2 induce caspase-3-independent degradation of Akt/protein kinase B.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Endotoxin and cytokines increase hepatic sphingolipid biosynthesis and produce lipoproteins enriched in ceramides and sphingomyelin

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

The role of non-esterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects: results of the Paris Prospective Study.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058729

Ceramide metabolism is affected by obesity and diabetes in human adipose tissue

27 November 2018

1 reference

12 December 2020

Sphingolipid biosynthesis de novo by rat hepatocytes in culture. Ceramide and sphingomyelin are associated with, but not required for, very low density lipoprotein secretion

1 reference

12 December 2020

Protein kinase Czeta is a negative regulator of protein kinase B activity

1 reference

12 December 2020

Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans

1 reference

12 December 2020

Increased skeletal muscle ceramide level in men at risk of developing type 2 diabetes

1 reference

12 December 2020

The sphingosine-1-phosphate analog FTY720 reduces muscle ceramide content and improves glucose tolerance in high fat-fed male mice

1 reference

12 December 2020

The pleckstrin homology domain of RAC protein kinase associates with the regulatory domain of protein kinase C zeta

1 reference

12 December 2020

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

1 reference

12 December 2020

Lipid oxidation is reduced in obese human skeletal muscle

1 reference

12 December 2020

Sphingomyelinase and ceramide suppress insulin-induced tyrosine phosphorylation of the insulin receptor substrate-1

1 reference

12 December 2020

Myriocin, a new antifungal antibiotic from Myriococcum albomyces

1 reference

12 December 2020

Identifiers

DOI

10.4239/WJD.V5.I3.244

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24936246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24936246%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24936246%20AND%20SRC:MED&resulttype=core&format=json