(Q38273535)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25893294%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

title

Development of secondary mutations in wild-type and mutant EZH2 alleles cooperates to confer resistance to EZH2 inhibitors (English)

1 reference

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6 March 2020

13

1 reference

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6 March 2020

author name string

V Gibaja

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25893294%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

F Shen

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25893294%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

J Harari

3

1 reference

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6 March 2020

J Korn

4

1 reference

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6 March 2020

D Ruddy

5

1 reference

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6 March 2020

V Saenz-Vash

6

1 reference

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6 March 2020

H Zhai

7

1 reference

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6 March 2020

T Rejtar

8

1 reference

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6 March 2020

C G Paris

9

1 reference

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6 March 2020

Z Yu

10

1 reference

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6 March 2020

M Lira

11

1 reference

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6 March 2020

D King

12

1 reference

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6 March 2020

N Keen

14

1 reference

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6 March 2020

A Q Hassan

15

1 reference

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6 March 2020

H M Chan

16

1 reference

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6 March 2020

language of work or name

English

0 references

publication date

20 April 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25893294%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25893294%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

volume

35

1 reference

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6 March 2020

issue

5

1 reference

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6 March 2020

page(s)

558-566

1 reference

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Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International

6 March 2020

copyright license

start time

20 April 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/onc.2015.114

0 references

cites work

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Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma

6 September 2017

1 reference

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Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

6 September 2017

1 reference

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Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers

6 September 2017

1 reference

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Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4744243

Identification of EZH2 and EZH1 small molecule inhibitors with selective impact on diffuse large B cell lymphoma cell growth

6 September 2017

1 reference

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Chromatin proteins and modifications as drug targets

6 September 2017

1 reference

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Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia

6 September 2017

1 reference

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Cancer drug resistance: an evolving paradigm

6 September 2017

1 reference

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Enzyme-dependent lysine deprotonation in EZH2 catalysis.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4744243

An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide).

6 September 2017

1 reference

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EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4744243

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2.

6 September 2017

1 reference

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Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4744243

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4744243

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4744243

Structural basis of substrate methylation and inhibition of SMYD2

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4744243

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4744243

Aberrations of EZH2 in cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4744243

The Polycomb complex PRC2 and its mark in life

6 September 2017

1 reference

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Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4744243

Structural Biology of Human H3K9 Methyltransferases

6 September 2017

1 reference

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Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4744243

MEK1 mutations confer resistance to MEK and B-RAF inhibition

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4744243

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency

6 September 2017

1 reference

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Roles of the EZH2 histone methyltransferase in cancer epigenetics

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4744243

Control of developmental regulators by Polycomb in human embryonic stem cells

6 September 2017

1 reference

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Polycomb complexes repress developmental regulators in murine embryonic stem cells

6 September 2017

1 reference

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Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4744243

Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer

14 September 2017

1 reference

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Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL.

23 June 2018

1 reference

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31 August 2018

Identifiers

DOI

10.1038/ONC.2015.114

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25893294%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

6 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25893294%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference