(Q38285137)

1 July 2019

2 references

28 September 2019

14 September 2020

Anticancer agents targeted to sirtuins (English)

1 reference

1 July 2019

1 reference

28 September 2019

1 reference

14 September 2020

Tomohiro Kozako

1

0 references

author name string

Takayoshi Suzuki

2

1 reference

1 July 2019

Makoto Yoshimitsu

3

1 reference

1 July 2019

Naomichi Arima

4

1 reference

1 July 2019

Shin-ichiro Honda

5

1 reference

1 July 2019

Shinji Soeda

6

1 reference

1 July 2019

language of work or name

English

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publication date

4 December 2014

3 references

1 July 2019

28 September 2019

14 September 2020

3 references

1 July 2019

28 September 2019

14 September 2020

19

1 reference

1 July 2019

issue

12

1 reference

1 July 2019

page(s)

20295-20313

1 reference

1 July 2019

Creative Commons Attribution

copyright license

2 references

28 September 2019

14 September 2020

0 references

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing

21 January 2018

2 references

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

21 January 2018

12 December 2020

Calorie restriction, SIRT1 and metabolism: understanding longevity

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Structural basis for sirtuin function: what we know and what we don't

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Sirtuins--novel therapeutic targets to treat age-associated diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Sirtuins in mammals: insights into their biological function

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

The type III histone deacetylase Sirt1 protein suppresses p300-mediated histone H3 lysine 56 acetylation at Bclaf1 promoter to inhibit T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene sirt1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

The critical role of the class III histone deacetylase SIRT1 in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T-cell leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Negative control of p53 by Sir2alpha promotes cell survival under stress

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Role of NAD-dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin-induced cell death in vertebrate cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

SIRT2-mediated protein deacetylation: An emerging key regulator in brain physiology and pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

SIRT2 activity is required for the survival of C6 glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Cellular histone modification patterns predict prognosis and treatment response in resectable pancreatic adenocarcinoma: results from RTOG 9704.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Global levels of histone modifications predict prognosis in different cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Alkylating agents induce histone H3K18 hyperacetylation and potentiate HDAC inhibitor-mediated global histone acetylation and cytotoxicity in mantle cell lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Function of the SIRT1 protein deacetylase in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

[New treatment strategy for adult T-cell leukemia targeting for anti-tumor immunity and a longevity gene-encoded protein].

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

High histone deacetylase 7 (HDAC7) expression is significantly associated with adenocarcinomas of the pancreas.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

The response of autologous T cells to a human melanoma is dominated by mutated neoantigens

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Aging and cancer: are sirtuins the link?

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Die another way--non-apoptotic mechanisms of cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Mitochondria and cell death: outer membrane permeabilization and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Identification of small molecule inhibitors of phosphatidylinositol 3-kinase and autophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Caspase-independent cell death: leaving the set without the final cut.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

p53 Activation: a case against Sir.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

p53 mutations in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

SIRT1 and p53, effect on cancer, senescence and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

The E2F transcriptional network: old acquaintances with new faces

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

FOXO transcription factors at the interface between longevity and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

FOXOs, cancer and regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

SIRT3 is pro-apoptotic and participates in distinct basal apoptotic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Anti-neoplastic activity of the cytosolic FoxO1 results from autophagic cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Sirtuin activators and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Identification of a small molecule inhibitor of Sir2p

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

SIRT1 inactivation induces inflammation through the dysregulation of autophagy in human THP-1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Adenovirus small e1a alters global patterns of histone modification

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Resveratrol suppresses cell proliferation via inhibition of STAT3 phosphorylation and Mcl-1 and cIAP-2 expression in HTLV-1-infected T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Resveratrol suppresses prostate cancer progression in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Resveratrol, but not EGCG, in the diet suppresses DMBA-induced mammary cancer in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivin

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Resveratrol-activated AMPK/SIRT1/autophagy in cellular models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Effects of Longevinex (modified resveratrol) on cardioprotection and its mechanisms of action

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Mechanism of human SIRT1 activation by resveratrol

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Resveratrol is not a direct activator of SIRT1 enzyme activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Death Receptor Pathway Activation and Increase of ROS Production by the Triple Epigenetic Inhibitor UVI5008

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES191220295

Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells

21 January 2018

1 reference

12 December 2020

The journey of resveratrol from yeast to human

1 reference

12 December 2020

Amurensin G, a novel SIRT1 inhibitor, sensitizes TRAIL-resistant human leukemic K562 cells to TRAIL-induced apoptosis

1 reference

12 December 2020

SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation

1 reference

12 December 2020

Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells

1 reference

12 December 2020

Discovery and validation of SIRT2 inhibitors based on tenovin-6: use of a ¹H-NMR method to assess deacetylase activity

1 reference

12 December 2020

Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae

1 reference

12 December 2020

10.3390/MOLECULES191220295

Identifiers

DOI

1 reference

1 July 2019

release_y3vqbakpp5e2vp3nt36epwy5lm

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/y3vqbakpp5e2vp3nt36epwy5lm

24 November 2022

mapped directly with Wikidata item

PMC publication ID

6270850

1 reference

1 July 2019

PubMed publication ID

25486244

1 reference

1 July 2019