(Q38293159)

1 September 2017

title

Designer protein delivery: From natural to engineered affinity-controlled release systems (English)

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1 September 2017

3

Molly S Shoichet

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1 September 2017

Malgosia M Pakulska

1

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1 September 2017

Shane Miersch

series ordinal

2

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1 September 2017

language of work or name

English

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publication date

1 March 2016

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1 September 2017

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1 September 2017

volume

351

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1 September 2017

issue

6279

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1 September 2017

page(s)

aac4750

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Review of insulin and its analogues in diabetes mellitus

1 September 2017

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Sensing the heat: the application of isothermal titration calorimetry to thermodynamic studies of biomolecular interactions

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Application of fluorescence energy transfer and polarization to monitor Escherichia coli cAMP receptor protein and lac promoter interaction

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Development of FRET assay into quantitative and high-throughput screening technology platforms for protein-protein interactions

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Higher throughput calorimetry: opportunities, approaches and challenges

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SPR microscopy and its applications to high-throughput analyses of biomolecular binding events and their kinetics

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Label-free measuring and mapping of binding kinetics of membrane proteins in single living cells

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Parallel microfluidic surface plasmon resonance imaging arrays.

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A versatile QCM matrix system for online and high-throughput bio-sensing

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Massively parallel measurements of molecular interaction kinetics on a microfluidic platform

21 January 2018

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A systems approach to measuring the binding energy landscapes of transcription factors

21 January 2018

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Protein-heparin interactions measured by BIAcore 2000 are affected by the method of heparin immobilization

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Determination of protein binding affinities within hydrogel-based molecularly imprinted polymers (HydroMIPs).

21 January 2018

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Measurement of protein-ligand binding constants from reaction-diffusion concentration profiles

21 January 2018

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Aptamers Selected for Higher-Affinity Binding Are Not More Specific for the Target Ligand

21 January 2018

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The role of charged residues mediating low affinity protein-protein recognition at the cell surface by CD2

21 January 2018

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Molecular and biological constraints on ligand-binding affinity and specificity

21 January 2018

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Incorporation of heparin into biomaterials

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Basic fibroblast growth factor enhances the coupling of intimal hyperplasia and proliferation of vasa vasorum in injured rat arteries

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Controlled and modulated release of basic fibroblast growth factor

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Heparin-immobilized biodegradable scaffolds for local and sustained release of angiogenic growth factor

21 January 2018

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Heparin-regulated release of growth factors in vitro and angiogenic response in vivo to implanted hyaluronan hydrogels containing VEGF and bFGF.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Controlled release of nerve growth factor from a heparin-containing fibrin-based cell ingrowth matrix

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Controlled release of neurotrophin-3 from fibrin gels for spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Affinity-based growth factor delivery using biodegradable, photocrosslinked heparin-alginate hydrogels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

The effect of sulfation of alginate hydrogels on the specific binding and controlled release of heparin-binding proteins

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Gelatin as a delivery vehicle for the controlled release of bioactive molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Recombinant collagen and gelatin for drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Affinity-Based Drug Delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Molecularly imprinted polymers for the recognition of proteins: the state of the art.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

The osteogenic effect of bone morphogenetic protein-2 on the collagen scaffold conjugated with antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Tunable growth factor delivery from injectable hydrogels for tissue engineering

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Affinity-based release of chondroitinase ABC from a modified methylcellulose hydrogel

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

MimoDB 2.0: a mimotope database and beyond

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Directed evolution of a fluorogen-activating single chain antibody for function and enhanced brightness in the cytoplasm

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Engineering novel binding proteins from nonimmunoglobulin domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Alternative non-antibody scaffolds for molecular recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Directed evolution for drug and nucleic acid delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Discovery of a sulfated tetrapeptide that binds to vascular endothelial growth factor

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

The synthesis of blocked triplet-phosphoramidites and their use in mutagenesis

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Trinucleotide phosphoramidites: ideal reagents for the synthesis of mixed oligonucleotides for random mutagenesis

21 January 2018

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Codon-based mutagenesis using dimer-phosphoramidites

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

DNA shuffling by random fragmentation and reassembly: in vitro recombination for molecular evolution

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Protein engineering: navigating between chance and reason

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Directed in vitro evolution and crystallographic analysis of a peptide-binding single chain antibody fragment (scFv) with low picomolar affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Chemical and biochemical strategies for the randomization of protein encoding DNA sequences: library construction methods for directed evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Economical analysis of saturation mutagenesis experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Reducing codon redundancy and screening effort of combinatorial protein libraries created by saturation mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Tolerance of the archaeal Sac7d scaffold protein to alternative library designs: characterization of anti-immunoglobulin G Affitins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

An engineered lipocalin specific for CTLA-4 reveals a combining site with structural and conformational features similar to antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Challenges and opportunities for non-antibody scaffold drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Teaching an Old Scaffold New Tricks: Monobodies Constructed Using Alternative Surfaces of the FN3 Scaffold

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Computational design of binding proteins to EGFR domain II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

First-in-human phase I study of PRS-050 (Angiocal), an Anticalin targeting and antagonizing VEGF-A, in patients with advanced solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Vascular endothelial growth factor in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Synthetic antibodies: concepts, potential and practical considerations

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Expansion of protein interaction maps by phage peptide display using MDM2 as a prototypical conformationally flexible target protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Binding proteins selected from combinatorial libraries of an alpha-helical bacterial receptor domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Design of an optimized scaffold for affibody molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Development of rationally designed affinity-based drug delivery systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Rationally designed peptides for controlled release of nerve growth factor from fibrin matrices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Production and fluorescence-activated cell sorting of Escherichia coli expressing a functional antibody fragment on the external surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Rapid isolation of high-affinity protein binding peptides using bacterial display

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

The cystine knot of a squash-type protease inhibitor as a structural scaffold for Escherichia coli cell surface display of conformationally constrained peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Bacterial display using circularly permuted outer membrane protein OmpX yields high affinity peptide ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Antibody affinity maturation using bacterial surface display.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

A decade of yeast surface display technology: where are we now?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Yeast surface display for screening combinatorial polypeptide libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Yeast surface display for protein engineering and characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

In-vitro protein evolution by ribosome display and mRNA display

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Design of cyclic peptides that bind protein surfaces with antibody-like affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Serum stable natural peptides designed by mRNA display

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Engineering of a macromolecular scaffold to develop specific protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Engineering of bispecific affinity proteins with high affinity for ERBB2 and adaptable binding to albumin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

In vitro selection of RNA molecules that bind specific ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Developing aptamers into therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Measurement of intracellular (compartmental) pH by 31P NMR in Aspergillus niger

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Using in vitro selection to direct the covalent attachment of human immunodeficiency virus type 1 Rev protein to high-affinity RNA ligands

21 January 2018

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Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease

21 January 2018

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Nanoparticle-aptamer bioconjugates for cancer targeting.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Quantitative selection and parallel characterization of aptamers

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Enhanced loading and controlled release of antibiotics using nucleic acids as an antibiotic-binding effector in hydrogels

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

In vitro selection of shape-changing DNA nanostructures capable of binding-induced cargo release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Design of a Novel Globular Protein Fold with Atomic-Level Accuracy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Kemp elimination catalysts by computational enzyme design

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Computational design of ligand-binding proteins with high affinity and selectivity

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Computational Design of a Protein-Based Enzyme Inhibitor

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Computational design of protein-ligand interfaces: potential in therapeutic development

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Computational design of protein-protein interactions

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

A De Novo Protein Binding Pair By Computational Design and Directed Evolution

21 January 2018

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Covalent docking predicts substrates for haloalkanoate dehalogenase superfamily phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Computational design of a pH-sensitive IgG binding protein

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

The relevance of tumour pH to the treatment of malignant disease

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

A review of stimuli-responsive nanocarriers for drug and gene delivery

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Incorporation of protein flexibility and conformational energy penalties in docking screens to improve ligand discovery

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

De novo computational design of retro-aldol enzymes

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Growth of novel protein structural data.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Modeller: generation and refinement of homology-based protein structure models

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

Recombinant gelatin hydrogels for the sustained release of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

The dead-end elimination theorem and its use in protein side-chain positioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAC4750

21 January 2018

Identifiers

DOI

10.1126/SCIENCE.AAC4750

1 reference

1 September 2017

1 reference