(Q38295075)

1 September 2017

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title

NEDD4: The founding member of a family of ubiquitin-protein ligases (English)

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1 September 2017

part of the series

Gene Wiki Review Series

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author

Sharad Kumar

series ordinal

2

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1 September 2017

Natasha Anne Boase

1

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1 September 2017

language of work or name

English

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publication date

17 December 2014

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1 September 2017

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1 September 2017

volume

557

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1 September 2017

issue

2

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1 September 2017

page(s)

113-122

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Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions

1 September 2017

cites work

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12 December 2020

mGrb10 interacts with Nedd4

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12 December 2020

The Epstein-Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases

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12 December 2020

Apical membrane targeting of Nedd4 is mediated by an association of its C2 domain with annexin XIIIb

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12 December 2020

A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: implications for filovirus budding

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12 December 2020

The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel

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12 December 2020

Distinct characteristics of two human Nedd4 proteins with respect to epithelial Na(+) channel regulation

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12 December 2020

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12 December 2020

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.

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12 December 2020

Ligand-independent degradation of epidermal growth factor receptor involves receptor ubiquitylation and Hgs, an adaptor whose ubiquitin-interacting motif targets ubiquitylation by Nedd4.

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12 December 2020

The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels

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12 December 2020

The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor

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12 December 2020

WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation

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12 December 2020

The Mason-Pfizer monkey virus PPPY and PSAP motifs both contribute to virus release

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12 December 2020

Identification of a set of genes with developmentally down-regulated expression in the mouse brain

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12 December 2020

Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins

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12 December 2020

Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

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12 December 2020

The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture

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12 December 2020

Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation

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12 December 2020

The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo

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12 December 2020

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

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12 December 2020

Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation

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12 December 2020

Tsg101 and Alix interact with murine leukemia virus Gag and cooperate with Nedd4 ubiquitin ligases during budding

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12 December 2020

The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities

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12 December 2020

Regulation of functional diversity within the Nedd4 family by accessory and adaptor proteins

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12 December 2020

Ubiquitin protein ligase Nedd4 binds to connexin43 by a phosphorylation-modulated process

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12 December 2020

Molecular mechanisms of coupled monoubiquitination

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12 December 2020

Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination

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12 December 2020

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

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12 December 2020

Ubiquitination regulates PTEN nuclear import and tumor suppression

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12 December 2020

COBALT: constraint-based alignment tool for multiple protein sequences

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12 December 2020

The Nedd4-like family of E3 ubiquitin ligases and cancer

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12 December 2020

Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1

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12 December 2020

Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization

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12 December 2020

ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response

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12 December 2020

Estimation of the number of amino acid substitutions per site when the substitution rate varies among sites.

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12 December 2020

Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor

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12 December 2020

The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization

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12 December 2020

Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis

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12 December 2020

gamma2-Adaptin, a ubiquitin-interacting adaptor, is a substrate to coupled ubiquitination by the ubiquitin ligase Nedd4 and functions in the endosomal pathway

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12 December 2020

Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2

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12 December 2020

Nedd4 controls animal growth by regulating IGF-1 signaling

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12 December 2020

Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins

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12 December 2020

Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells

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12 December 2020

The cyclin-dependent kinase activator, Spy1A, is targeted for degradation by the ubiquitin ligase NEDD4.

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12 December 2020

The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4

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12 December 2020

Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cells

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12 December 2020

Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins

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12 December 2020

Abnormal development of the neuromuscular junction in Nedd4-deficient mice

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12 December 2020

Rak functions as a tumor suppressor by regulating PTEN protein stability and function

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12 December 2020

Physiological functions of the HECT family of ubiquitin ligases

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12 December 2020

RING domain E3 ubiquitin ligases

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12 December 2020

Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions

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12 December 2020

Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons

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12 December 2020

Regulation of Marburg virus (MARV) budding by Nedd4.1: a different WW domain of Nedd4.1 is critical for binding to MARV and Ebola virus VP40.

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12 December 2020

Eps15 interacts with ubiquitinated Cx43 and mediates its internalization

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12 December 2020

Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays

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12 December 2020

The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1

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12 December 2020

HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK

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12 December 2020

Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc

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12 December 2020

E3 ligase Nedd4 promotes axon branching by downregulating PTEN

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12 December 2020

Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development

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12 December 2020

Calcium activates Nedd4 E3 ubiquitin ligases by releasing the C2 domain-mediated auto-inhibition

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12 December 2020

FoxM1B regulates NEDD4-1 expression, leading to cellular transformation and full malignant phenotype in immortalized human astrocytes

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12 December 2020

The ESCRT-associated protein Alix recruits the ubiquitin ligase Nedd4-1 to facilitate HIV-1 release through the LYPXnL L domain motif

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12 December 2020

Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor.

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12 December 2020

Nedd4-1 and β-Arrestin-1 Are Key Regulators of Na+/H+ Exchanger 1 Ubiquitylation, Endocytosis, and Function

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12 December 2020

Ndfip1-deficient mice have impaired DMT1 regulation and iron homeostasis

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12 December 2020

Drosophila Ndfip is a novel regulator of Notch signaling

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12 December 2020

CDD: a Conserved Domain Database for the functional annotation of proteins

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12 December 2020

Neuronal precursor cell-expressed developmentally down-regulated 4-1 (NEDD4-1) controls the sorting of newly synthesized Ca(V)1.2 calcium channels

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12 December 2020

Nedd4-mediated AMPA receptor ubiquitination regulates receptor turnover and trafficking

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12 December 2020

Respiratory distress and perinatal lethality in Nedd4-2-deficient mice

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12 December 2020

Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function

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12 December 2020

Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1.

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12 December 2020

Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway

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12 December 2020

Rac1 acts in conjunction with Nedd4 and dishevelled-1 to promote maturation of cell-cell contacts

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12 December 2020

Disruption of E3 ligase NEDD4 in peripheral neurons interrupts axon outgrowth: Linkage to PTEN.

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12 December 2020

Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9.

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12 December 2020

E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity

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12 December 2020

Upregulation of the E3 ligase NEDD4-1 by oxidative stress degrades IGF-1 receptor protein in neurodegeneration

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12 December 2020

NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway

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12 December 2020

Identification of Nedd4 as a novel regulator in Hedgehog signaling.

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12 December 2020

The ubiquitin ligase Nedd4-1 participates in denervation-induced skeletal muscle atrophy in mice

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12 December 2020

The histone deacetylase SIRT2 stabilizes Myc oncoproteins

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12 December 2020

Ubiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 response

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12 December 2020

Nedd4 and Nedd4-2: ubiquitin ligases at work in the neuron.

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12 December 2020

Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects

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12 December 2020

Upregulation of SIRT1 by 17β-estradiol depends on ubiquitin-proteasome degradation of PPAR-γ mediated by NEDD4-1.

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12 December 2020

ΔNp63α represses nuclear translocation of PTEN by inhibition of NEDD4-1 in keratinocytes

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12 December 2020

The Nedd4-binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in developing neurons

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12 December 2020

The ubiquitin ligase Nedd4 regulates craniofacial development by promoting cranial neural crest cell survival and stem-cell like properties

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12 December 2020

NEDD4 E3 ligase inhibits the activity of the Hippo pathway by targeting LATS1 for degradation

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12 December 2020

p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN.

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12 December 2020

Lipopolysaccharide induces degradation of connexin43 in rat astrocytes via the ubiquitin-proteasome proteolytic pathway

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12 December 2020

Subtle gait abnormalities in Nedd4 heterozygous mice

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12 December 2020

Regulation of Mdm2 protein stability and the p53 response by NEDD4-1 E3 ligase

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12 December 2020

SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway

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12 December 2020

The E3 ubiquitin ligase NEDD4 negatively regulates HER3/ErbB3 level and signaling.

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12 December 2020

Impeded Nedd4-1-mediated Ras degradation underlies Ras-driven tumorigenesis.

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12 December 2020

PTEN is a protein tyrosine phosphatase for IRS1

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12 December 2020

Regulation of p63 protein stability via ubiquitin-proteasome pathway

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12 December 2020

Abnormal splicing of NEDD4 in myotonic dystrophy type 2: possible link to statin adverse reactions

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12 December 2020

The antiproliferative response of indole-3-carbinol in human melanoma cells is triggered by an interaction with NEDD4-1 and disruption of wild-type PTEN degradation

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12 December 2020

NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation

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12 December 2020

NEDD4: a promising target for cancer therapy

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12 December 2020

Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth.

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12 December 2020

SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization

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12 December 2020

Brucella infection inhibits macrophages apoptosis via Nedd4-dependent degradation of calpain2.

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12 December 2020

Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity.

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12 December 2020

Peptide and small molecule inhibitors of HECT-type ubiquitin ligases

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12 December 2020

NEDD4-2 (NEDD4L): the ubiquitin ligase for multiple membrane proteins

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12 December 2020

Characterization of a novel protein-binding module--the WW domain

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12 December 2020

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

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12 December 2020

The WW domain: a signalling site in dystrophin?

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12 December 2020

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

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12 December 2020

WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome

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12 December 2020

cDNA cloning, expression analysis, and mapping of the mouse Nedd4 gene.

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12 December 2020

Nedd4 mediates control of an epithelial Na+ channel in salivary duct cells by cytosolic Na+

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12 December 2020

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12 December 2020

Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes

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12 December 2020

10.1016/J.GENE.2014.12.020

Identifiers

DOI

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1 September 2017

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