(Q38363335)

2 September 2017

1 reference

title

Key mediators of intracellular amino acids signaling to mTORC1 activation (English)

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2 September 2017

Yehui Duan

1

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2 September 2017

Fengna Li

2

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2 September 2017

Kunrong Tan

3

1 reference

2 September 2017

Hongnan Liu

4

1 reference

2 September 2017

Yinghui Li

5

1 reference

2 September 2017

Yingying Liu

6

1 reference

2 September 2017

Xiangfeng Kong

7

1 reference

2 September 2017

Yulong Tang

8

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2 September 2017

Guoyao Wu

9

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2 September 2017

Yulong Yin

10

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2 September 2017

21 February 2015

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2 September 2017

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2 September 2017

47

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2 September 2017

5

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2 September 2017

857-867

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https://scigraph.springernature.com/pub.10.1007/s00726-015-1937-x

2 September 2017

0 references

cites work

Thinking globally and acting locally with TOR.

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

The Rheb family of GTP-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Key factors in mTOR regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Mutations affecting the repressibility of arginine biosynthetic enzymes in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Where is mTOR and what is it doing there?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Identification of pathways regulating cell size and cell-cycle progression by RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Leucyl-tRNA synthetase controls TORC1 via the EGO complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Phospholipase D confers rapamycin resistance in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Leucine is a major regulator of muscle protein synthesis in neonates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

The TOR signalling network from yeast to man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Impaired translation initiation activation and reduced protein synthesis in weaned piglets fed a low-protein diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Leucine and mTORC1: a complex relationship

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Glutaminolysis activates Rag-mTORC1 signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Nutrients and growth factors in mTORC1 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Amino acids and mTORC1: from lysosomes to disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Phosphatidic acid-mediated mitogenic activation of mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

The late endosome is essential for mTORC1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Tissue specificity of mitochondrial glutamate pathways and the control of metabolic homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Regulation of translation initiation by FRAP/mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Activation of S6K1 (p70 ribosomal protein S6 kinase 1) requires an initial calcium-dependent priming event involving formation of a high-molecular-mass signalling complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Complexity of the TOR signaling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Subunit H of the vacuolar (H+) ATPase inhibits ATP hydrolysis by the free V1 domain by interaction with the rotary subunit F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Amino acid regulation of TOR complex 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Mechanisms of amino acid sensing in mTOR signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Amino acid signaling in TOR activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Regulation of TORC1 by Rag GTPases in nutrient response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Amino acid signaling to mTOR mediated by inositol polyphosphate multikinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

L-Arginine stimulates the mTOR signaling pathway and protein synthesis in porcine trophectoderm cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

mTOR signaling at a glance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

TSC2: filling the GAP in the mTOR signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Leucine nutrition in animals and humans: mTOR signaling and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

The structure and allosteric regulation of mammalian glutamate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Rheb binds and regulates the mTOR kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

RalA functions as an indispensable signal mediator for the nutrient-sensing system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Rheb fills a GAP between TSC and TOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Bidirectional transport of amino acids regulates mTOR and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates TORC1 on late endosomal and lysosomal membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

The vacuolar (H+)-ATPase: subunit arrangement and in vivo regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

MAP4K3 is a component of the TORC1 signalling complex that modulates cell growth and viability in Drosophila melanogaster.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Regulation of the small GTPase Rheb by amino acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Growing roles for the mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Phospholipase D1 is an effector of Rheb in the mTOR pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Spatial regulation of the mTORC1 system in amino acids sensing pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

L-Arginine stimulates proliferation and prevents endotoxin-induced death of intestinal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Role of amino acid transporters in amino acid sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Nutrient control of TORC1, a cell-cycle regulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Amino acid availability regulates p70 S6 kinase and multiple translation factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Arginine metabolism and nutrition in growth, health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

TOR signaling in growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

21 January 2018

Expanding mTOR signaling

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Control of cell growth: Rag GTPases in activation of TORC1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Alpha-ketoglutarate inhibits glutamine degradation and enhances protein synthesis in intestinal porcine epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Supplementing L-leucine to a low-protein diet increases tissue protein synthesis in weanling pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

Termination of autophagy and reformation of lysosomes regulated by mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-015-1937-X

10.1007/S00726-015-1937-X

21 January 2018

Identifiers

DOI

1 reference

2 September 2017

1 reference