(Q38364456)

2 September 2017

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title

The role of regulatory variation in complex traits and disease (English)

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2 September 2017

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Frank W Albert

1

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author name string

Leonid Kruglyak

series ordinal

2

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2 September 2017

24 February 2015

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2 September 2017

Nature Reviews Genetics

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2 September 2017

16

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2 September 2017

197-212

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2 September 2017

4

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https://scigraph.springernature.com/pub.10.1038/nrg3891

2 September 2017

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Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles

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Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Identification and validation of genetic variants that influence transcription factor and cell signaling protein levels.

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Identification of genetic variants influencing the human plasma proteome

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Genetic variation shapes protein networks mainly through non-transcriptional mechanisms

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling

31 March 2020

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Genetic influences on translation in yeast

31 March 2020

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31 March 2020

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31 March 2020

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Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors.

31 March 2020

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Evolution of transcription factor binding in metazoans - mechanisms and functional implications

31 March 2020

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A molecular basis for classic blond hair color in Europeans

31 March 2020

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31 March 2020

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Overlapping and distinct roles of the duplicated yeast transcription factors Ace2p and Swi5p

31 March 2020

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31 March 2020

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Genotype-environment interactions reveal causal pathways that mediate genetic effects on phenotype

31 March 2020

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Single nucleotide variants in transcription factors associate more tightly with phenotype than with gene expression

31 March 2020

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Genetic interactions between transcription factors cause natural variation in yeast

31 March 2020

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Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases

31 March 2020

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The accessible chromatin landscape of the human genome

31 March 2020

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Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations

31 March 2020

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Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS

31 March 2020

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Biological insights from 108 schizophrenia-associated genetic loci

31 March 2020

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Cross-tissue and tissue-specific eQTLs: partitioning the heritability of a complex trait

31 March 2020

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An enhancer polymorphism at the cardiomyocyte intercalated disc protein NOS1AP locus is a major regulator of the QT interval

31 March 2020

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The Genotype-Tissue Expression (GTEx) project

31 March 2020

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Powerful identification of cis-regulatory SNPs in human primary monocytes using allele-specific gene expression

31 March 2020

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Genetics and beyond--the transcriptome of human monocytes and disease susceptibility

31 March 2020

1 reference

Allelic expression mapping across cellular lineages to establish impact of non-coding SNPs

31 March 2020

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Intersection of population variation and autoimmunity genetics in human T cell activation

31 March 2020

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Interindividual variation in human T regulatory cells

31 March 2020

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Impact of natural genetic variation on gene expression dynamics.

31 March 2020

1 reference

Expression quantitative trait loci are highly sensitive to cellular differentiation state

31 March 2020

1 reference

The promise of induced pluripotent stem cells in research and therapy

31 March 2020

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Genetic background drives transcriptional variation in human induced pluripotent stem cells

31 March 2020

1 reference

Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes

31 March 2020

1 reference

Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection

31 March 2020

1 reference

Genetics of gene expression in immunity to infection

31 March 2020

1 reference

Integrative genomic analysis of the human immune response to influenza vaccination

31 March 2020

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Linking disease associations with regulatory information in the human genome

31 March 2020

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Genetic and epigenetic fine mapping of causal autoimmune disease variants

31 March 2020

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All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs

31 March 2020

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Chromatin marks identify critical cell types for fine mapping complex trait variants

31 March 2020

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Joint analysis of functional genomic data and genome-wide association studies of 18 human traits

31 March 2020

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Integrating functional data to prioritize causal variants in statistical fine-mapping studies

31 March 2020

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A Bayesian method to incorporate hundreds of functional characteristics with association evidence to improve variant prioritization.

31 March 2020

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GPA: a statistical approach to prioritizing GWAS results by integrating pleiotropy and annotation

31 March 2020

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Using functional annotation for the empirical determination of Bayes Factors for genome-wide association study analysis

31 March 2020

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Dissecting the regulatory architecture of gene expression QTLs

31 March 2020

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Integrative modeling of eQTLs and cis-regulatory elements suggests mechanisms underlying cell type specificity of eQTLs

31 March 2020

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A statistical framework for joint eQTL analysis in multiple tissues

31 March 2020

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Robust prediction of expression differences among human individuals using only genotype information

31 March 2020

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Using prior information from the medical literature in GWAS of oral cancer identifies novel susceptibility variant on chromosome 4--the AdAPT method

31 March 2020

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Bayesian test for colocalisation between pairs of genetic association studies using summary statistics

31 March 2020

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Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

31 March 2020

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Erratum: Corrigendum: Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes

31 March 2020

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Mapping complex disease traits with global gene expression

31 March 2020

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A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

31 March 2020

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Inactivation of the Fto gene protects from obesity

31 March 2020

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Obesity-associated variants within FTO form long-range functional connections with IRX3

31 March 2020

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Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions.

31 March 2020

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Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C).

31 March 2020

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Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements

31 March 2020

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Unbiased analysis of potential targets of breast cancer susceptibility loci by Capture Hi-C.

31 March 2020

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Capturing chromosome conformation

31 March 2020

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Comprehensive mapping of long-range interactions reveals folding principles of the human genome

31 March 2020

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Investigating human disease using stem cell models

31 March 2020

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Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq

31 March 2020

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Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types

31 March 2020

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The landscape of genetic complexity across 5,700 gene expression traits in yeast

31 March 2020

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RETRACTED ARTICLE: Detection and replication of epistasis influencing transcription in humans

31 March 2020

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Genetic interactions affecting human gene expression identified by variance association mapping

31 March 2020

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Another explanation for apparent epistasis

31 March 2020

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Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins

31 March 2020

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Data and theory point to mainly additive genetic variance for complex traits

31 March 2020

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Influence of gene interaction on complex trait variation with multilocus models

31 March 2020

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A statin-dependent QTL for GATM expression is associated with statin-induced myopathy

31 March 2020

1 reference

Development and applications of CRISPR-Cas9 for genome engineering

31 March 2020

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CRISPR-Cas systems for editing, regulating and targeting genomes

31 March 2020

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Tackling the widespread and critical impact of batch effects in high-throughput data

31 March 2020

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On the design and analysis of gene expression studies in human populations

31 March 2020

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Capturing heterogeneity in gene expression studies by surrogate variable analysis

31 March 2020

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A Bayesian framework to account for complex non-genetic factors in gene expression levels greatly increases power in eQTL studies

31 March 2020

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Genetic and nongenetic variation revealed for the principal components of human gene expression

31 March 2020

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Joint modelling of confounding factors and prominent genetic regulators provides increased accuracy in genetical genomics studies

31 March 2020

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Using probabilistic estimation of expression residuals (PEER) to obtain increased power and interpretability of gene expression analyses

31 March 2020

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Correction for hidden confounders in the genetic analysis of gene expression

31 March 2020

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Accurate discovery of expression quantitative trait loci under confounding from spurious and genuine regulatory hotspots

31 March 2020

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HEFT: eQTL analysis of many thousands of expressed genes while simultaneously controlling for hidden factors

31 March 2020

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Accounting for non-genetic factors by low-rank representation and sparse regression for eQTL mapping

31 March 2020

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Normalizing RNA-sequencing data by modeling hidden covariates with prior knowledge

31 March 2020

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Joint genetic analysis of gene expression data with inferred cellular phenotypes

31 March 2020

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Identifying the genetic determinants of transcription factor activity

31 March 2020

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Harnessing natural sequence variation to dissect posttranscriptional regulatory networks in yeast

31 March 2020

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The effects of genetic variation on gene expression dynamics during development

31 March 2020

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The Brisbane Systems Genetics Study: genetical genomics meets complex trait genetics

31 March 2020

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Global analysis of the impact of environmental perturbation on cis-regulation of gene expression

31 March 2020

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Genetic variability in the regulation of gene expression in ten regions of the human brain

31 March 2020

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Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants

31 March 2020

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Temporal dynamics and genetic control of transcription in the human prefrontal cortex

31 March 2020

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Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain

31 March 2020

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Genome-wide identification of expression quantitative trait loci (eQTLs) in human heart

31 March 2020

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Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue

31 March 2020

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Mapping the genetic architecture of gene expression in human liver

31 March 2020

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Lung eQTLs to help reveal the molecular underpinnings of asthma

31 March 2020

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Putative cis-regulatory drivers in colorectal cancer.

31 March 2020

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Expression QTL-based analyses reveal candidate causal genes and loci across five tumor types

31 March 2020

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Integrative eQTL-based analyses reveal the biology of breast cancer risk loci

31 March 2020

1 reference

Genetic Studies on Mutant Enzymes in Maize. III. Control of Gene Action in the Synthesis of Ph 7.5 Esterase

31 March 2020

1 reference

12 December 2020

Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes

1 reference

12 December 2020

Quantitative trait loci underlying gene product variation: a novel perspective for analyzing regulation of genome expression

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12 December 2020

Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling

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12 December 2020

Chitinase is required for cell separation during growth of Saccharomyces cerevisiae

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12 December 2020

Identifiers

DOI

10.1038/NRG3891

1 reference

PubMed ID

25707927

Dimensions Publication ID

2 September 2017

0 references

1 reference

PubMed ID

25707927