(Q38383297)

2 September 2017

1 reference

title

Clinical translation of RNAi-based treatments for respiratory diseases (English)

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2 September 2017

author name string

Borja Ballarín-González

series ordinal

1

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2 September 2017

Troels Bo Thomsen

series ordinal

2

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2 September 2017

Kenneth Alan Howard

series ordinal

3

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2 September 2017

publication date

1 February 2013

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Drug delivery and translational research

2 September 2017

published in

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2 September 2017

volume

3

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2 September 2017

issue

1

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2 September 2017

page(s)

84-99

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Respiratory syncytial virus pneumonia in the hospital setting: length of stay, charges, and mortality

2 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Interfering with disease: a progress report on siRNA-based therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Current prospects for RNA interference-based therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

RNAi-mediated pathways in the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

The role of the RNAi machinery in heterochromatin formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Gene silencing as an adaptive defence against viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Induction and suppression of RNA silencing by an animal virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

The rde-1 gene, RNA interference, and transposon silencing in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

RNAi protects the Caenorhabditis elegans germline against transposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Genetic and functional diversification of small RNA pathways in plants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Mechanisms of gene silencing by double-stranded RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Improved targeting of miRNA with antisense oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Antisense technologies. Improvement through novel chemical modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

microRNAs as oncogenes and tumor suppressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

OncomiRs: the discovery and progress of microRNAs in cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

A system for stable expression of short interfering RNAs in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

RNAi-inducing lentiviral vectors for anti-HIV-1 gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Attenuation of fibrosis in vitro and in vivo with SPARC siRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Blockade of the Wnt/β-catenin pathway attenuates bleomycin-induced pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

In vivo gene silencing (with siRNA) of pulmonary expression of MIP-2 versus KC results in divergent effects on hemorrhage-induced, neutrophil-mediated septic acute lung injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, inflammation, and neutrophil influx after hemorrhagic shock and sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Therapeutic accessibility of caspase-mediated cell death as a key pathomechanism in indirect acute lung injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Intrapulmonary delivery of XCL1-targeting small interfering RNA in mice chronically infected with Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

WT1 gene silencing by aerosol delivery of PEI-RNAi complexes inhibits B16-F10 lung metastases growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Influenza A viruses: new research developments

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Inhibition of influenza virus production in virus-infected mice by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Protection against lethal influenza virus challenge by RNA interference in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Human host factors required for influenza virus replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Respiratory syncytial virus: the virus, the disease and the immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Inhibition of respiratory viruses by nasally administered siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

RNA Interference Therapy in Lung Transplant Patients Infected with Respiratory Syncytial Virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Coronaviruses post-SARS: update on replication and pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

siRNA targeting the leader sequence of SARS-CoV inhibits virus replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Inhaling medicines: delivering drugs to the body through the lungs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Fundamentals of pulmonary drug delivery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Airway mucus function and dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Alveolar macrophages transport pathogens to lung draining lymph nodes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Uptake, efficacy, and systemic distribution of naked, inhaled short interfering RNA (siRNA) and locked nucleic acid (LNA) antisense

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

MUC1 cell surface mucin is a critical element of the mucosal barrier to infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Barrier properties of mucus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Micro- and macrorheology of mucus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Mucoadhesive nanoparticles may disrupt the protective human mucus barrier by altering its microstructure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Characterization of particle translocation through mucin hydrogels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Mucus clearance as a primary innate defense mechanism for mammalian airways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Naked siLNA-mediated gene silencing of lung bronchoepithelium EGFP expression after intravenous administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Efficient gene silencing in lungs and liver using imidazole-modified chitosan as a nanocarrier for small interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

RNAi-mediated suppression of constitutive pulmonary gene expression by small interfering RNA in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Pulmonary gene silencing in transgenic EGFP mice using aerosolised chitosan/siRNA nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Chitosan and its use as a pharmaceutical excipient

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Inhaled nanoparticles--a current review.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Nonviral siRNA delivery to the lung: investigation of PEG-PEI polyplexes and their in vivo performance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Comparative in vivo study of poly(ethylene imine)/siRNA complexes for pulmonary delivery in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Noninvasive delivery of small inhibitory RNA and other reagents to pulmonary alveoli in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Lung delivery studies using siRNA conjugated to TAT(48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Effective treatment of respiratory alphaherpesvirus infection using RNA interference.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

RNA interference inhibits respiratory syncytial virus replication and disease pathogenesis without inhibiting priming of the memory immune response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Respiratory syncytial virus infection in Fischer 344 rats is attenuated by short interfering RNA against the RSV-NS1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

RNA interference-mediated silencing of the respiratory syncytial virus nucleocapsid defines a potent antiviral strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Delivery of RNA interference therapeutics using polycation-based nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Scavenger receptor class-A is a novel cell surface receptor for double-stranded RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Innate immune recognition of viral infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

The role of type I interferons in TLR responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Small interfering RNA-induced TLR3 activation inhibits blood and lymphatic vessel growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Recognition of single-stranded RNA viruses by Toll-like receptor 7

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Identification of RNA sequence motifs stimulating sequence-specific TLR8-dependent immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Mechanistic Link between PKR Dimerization, Autophosphorylation, and eIF2α Substrate Recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Interactions between double-stranded RNA regulators and the protein kinase DAI

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

siRNA binding proteins of microglial cells: PKR is an unanticipated ligand.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Activation of the interferon system by short-interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Controlling activation of the RNA-dependent protein kinase by siRNAs using site-specific chemical modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Translation initiation: adept at adapting

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

5'-Triphosphate RNA is the ligand for RIG-I

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Artificial microRNAs as siRNA shuttles: improved safety as compared to shRNAs in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Cellular toxicity following application of adeno-associated viral vector-mediated RNA interference in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Expression profiling reveals off-target gene regulation by RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Effect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Hypoxia reduces constitutive and TNF-alpha-induced expression of monocyte chemoattractant protein-1 in human proximal renal tubular cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Asymmetric shorter-duplex siRNA structures trigger efficient gene silencing with reduced nonspecific effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Asymmetric RNA duplexes mediate RNA interference in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Potent RNAi by short RNA triggers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Improved silencing properties using small internally segmented interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Viral load drives disease in humans experimentally infected with respiratory syncytial virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13346-012-0098-7

Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque

21 January 2018

1 reference

12 December 2020

Structural requirements of double-stranded RNA for the activation of 2‘,5‘-oligo(A) polymerase and protein kinase of interferon-treated HeLa cells

1 reference

12 December 2020

Single-stranded small interfering RNA are more immunostimulatory than their double-stranded counterparts: a central role for 2'-hydroxyl uridines in immune responses

1 reference

12 December 2020

Studies on chitosan: 4. Lysozymic hydrolysis of partially N-acetylated chitosans

1 reference

12 December 2020

Polycation-based DNA complexes for tumor-targeted gene delivery in vivo

1 reference

12 December 2020

Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2)

1 reference

12 December 2020

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

1 reference

12 December 2020

Evaluation of the clearance characteristics of bioadhesive systems in humans

1 reference

12 December 2020

Signal integration via PKR.

1 reference

12 December 2020

In vitro degradation of chitosan by bacterial enzymes from rat cecal and colonic contents

1 reference

12 December 2020

Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs

1 reference

12 December 2020

The effects of thiophosphate substitutions on native siRNA gene silencing

1 reference

12 December 2020

Binding of cholera toxin to mucins and inhibition by gastric mucin

1 reference

12 December 2020

10.1007/S13346-012-0098-7

Identifiers

DOI

1 reference

Dimensions Publication ID

2 September 2017

1001488962

0 references

PMC publication ID

7097609

0 references

1 reference