(Q39636192)

13 September 2017

Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs (English)

1 reference

13 September 2017

0 references

Narendra Vaish

1

1 reference

13 September 2017

Feng Chen

2

1 reference

13 September 2017

Shaguna Seth

3

1 reference

13 September 2017

Kathy Fosnaugh

4

1 reference

13 September 2017

Yan Liu

5

1 reference

13 September 2017

Roger Adami

6

1 reference

13 September 2017

Tod Brown

7

1 reference

13 September 2017

Yan Chen

8

1 reference

13 September 2017

Pierrot Harvie

9

1 reference

13 September 2017

Rachel Johns

10

1 reference

13 September 2017

Gregory Severson

11

1 reference

13 September 2017

Brian Granger

12

1 reference

13 September 2017

Patrick Charmley

13

1 reference

13 September 2017

Michael Houston

14

1 reference

13 September 2017

Michael V Templin

15

1 reference

13 September 2017

Barry Polisky

16

1 reference

13 September 2017

language of work or name

English

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publication date

2 November 2010

1 reference

13 September 2017

Nucleic Acids Research

1 reference

13 September 2017

39

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13 September 2017

5

1 reference

13 September 2017

1823-1832

1 reference

Creative Commons Attribution-NonCommercial 2.5 Generic

13 September 2017

start time

7 November 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/3061082

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061082

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061082

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061082

siDirect 2.0: updated software for designing functional siRNA with reduced seed-dependent off-target effect

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061082

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061082

Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061082

Improved silencing properties using small internally segmented interfering RNAs

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061082

Linear models and empirical bayes methods for assessing differential expression in microarray experiments

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061082

siRNA-mediated off-target gene silencing triggered by a 7 nt complementation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061082

DINAMelt web server for nucleic acid melting prediction

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061082

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061082

Bioconductor: open software development for computational biology and bioinformatics

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061082

MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061082

Expression profiling reveals off-target gene regulation by RNAi

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061082

Specificity of short interfering RNA determined through gene expression signatures

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061082

Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5'-terminal phosphorylation both in vitro and in vivo.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061082

Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061082

Thermodynamic stability and Watson-Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061082

Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061082

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061082

UNA (unlocked nucleic acid): a flexible RNA mimic that allows engineering of nucleic acid duplex stability.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061082

Asymmetric RNA duplexes mediate RNA interference in mammalian cells.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3061082

A protocol for designing siRNAs with high functionality and specificity

21 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21047800

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Gene silencing with siRNA duplexes composed of target-mRNA-complementary and partially palindromic or partially complementary single-stranded siRNAs

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21047800

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NAR/GKQ961

1 reference

13 September 2017

1 reference

13 September 2017

PubMed publication ID

21047800

1 reference