(Q38383659)

2 September 2017

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title

The application of genome-wide 5-hydroxymethylcytosine studies in cancer research (English)

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2 September 2017

John P Thomson

1

1 reference

PubMed ID

27936926

2 September 2017

Richard R Meehan

series ordinal

2

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2 September 2017

12 December 2016

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2 September 2017

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2 September 2017

9

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2 September 2017

1

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2 September 2017

77-91

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Epigenetic modulators, modifiers and mediators in cancer aetiology and progression

2 September 2017

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Beyond transcription factors: how oncogenic signalling reshapes the epigenetic landscape

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

A global assessment of cancer genomic alterations in epigenetic mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

An integrative pan-cancer-wide analysis of epigenetic enzymes reveals universal patterns of epigenomic deregulation in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Genomic insights into cancer-associated aberrant CpG island hypermethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

DNA methylation patterns and epigenetic memory

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Lsh regulates LTR retrotransposon repression independently of Dnmt3b function

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Promoter DNA methylation couples genome-defence mechanisms to epigenetic reprogramming in the mouse germline

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

5-Hydroxymethylcytosine is a predominantly stable DNA modification.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Active and passive demethylation of male and female pronuclear DNA in the mammalian zygote

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Coming of age: ten years of next-generation sequencing technologies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Loss of 5-hydroxymethylcytosine in cancer: cause or consequence?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

TET1 is a tumour suppressor that inhibits colon cancer growth by derepressing inhibitors of the WNT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Suppression of TET1-dependent DNA demethylation is essential for KRAS-mediated transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Tumour hypoxia causes DNA hypermethylation by reducing TET activity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

5-hydroxymethylcytosine profiling as an indicator of cellular state

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Mapping recently identified nucleotide variants in the genome and transcriptome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Comparative analysis of affinity-based 5-hydroxymethylation enrichment techniques

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Active DNA demethylation at enhancers during the vertebrate phylotypic period

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Whole-genome analysis of the methylome and hydroxymethylome in normal and malignant lung and liver

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

5-Hydroxymethylcytosine Remodeling Precedes Lineage Specification during Differentiation of Human CD4(+) T Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

The epigenetic progenitor origin of human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

A decade of exploring the cancer epigenome - biological and translational implications

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Enhancer methylation dynamics contribute to cancer plasticity and patient mortality

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Integrated analyses of DNA methylation and hydroxymethylation reveal tumor suppressive roles of ECM1, ATF5, and EOMES in human hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Loss of Tet1-Associated 5-Hydroxymethylcytosine Is Concomitant with Aberrant Promoter Hypermethylation in Liver Cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Loss of 5-hydroxymethylcytosine and ten-eleven translocation 2 protein expression in malignant melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Decrease of 5-hydroxymethylcytosine is associated with progression of hepatocellular carcinoma through downregulation of TET1.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Role of TET enzymes in DNA methylation, development, and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Oncogenic EGFR Represses the TET1 DNA Demethylase to Induce Silencing of Tumor Suppressors in Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Epigenetic inactivation of the CpG demethylase TET1 as a DNA methylation feedback loop in human cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Hypoxia Drives Breast Tumor Malignancy through a TET-TNFα-p38-MAPK Signaling Axis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Hypermethylation of TET1 Promoter Is a New Diagnosic Marker for Breast Cancer Metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

SDH mutations establish a hypermethylator phenotype in paraganglioma.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Alterations of metabolic genes and metabolites in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Mutations in the fumarate hydratase gene cause hereditary leiomyomatosis and renal cell cancer in families in North America

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

TET1 is a tumor suppressor of hematopoietic malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Is DNA methylation of tumour suppressor genes epigenetic?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Mapping of Variable DNA Methylation Across Multiple Cell Types Defines a Dynamic Regulatory Landscape of the Human Genome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Oxidative bisulfite sequencing of 5-methylcytosine and 5-hydroxymethylcytosine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Epigenetic profiles as defined signatures of xenobiotic exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Dynamic changes in 5-hydroxymethylation signatures underpin early and late events in drug exposed liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Decrease of 5-hydroxymethylcytosine in rat liver with subchronic exposure to genotoxic carcinogens riddelliine and aristolochic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

CCN4/WISP1 (WNT1 inducible signaling pathway protein 1): a focus on its role in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Identification of Dlk1-Dio3 imprinted gene cluster noncoding RNAs as novel candidate biomarkers for liver tumor promotion

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Epigenetic reprogramming of melanoma cells by vitamin C treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

High levels of 5-hydroxymethylcytosine (5hmC) is an adverse predictor of biochemical recurrence after prostatectomy in ERG-negative prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

5-hydroxymethylcytosine loss is associated with poor prognosis for patients with WHO grade II diffuse astrocytomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Integrative DNA methylation and gene expression analysis to assess the universality of the CpG island methylator phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Modules, networks and systems medicine for understanding disease and aiding diagnosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

Characterization of acute myeloid leukemia based on levels of global hydroxymethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FEPI-2016-0122

21 January 2018

Identifiers

DOI

10.2217/EPI-2016-0122

1 reference

2 September 2017

1 reference

PubMed ID

27936926