(Q38418672)

2 September 2017

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title

The pyruvate dehydrogenase complex in cancer: An old metabolic gatekeeper regulated by new pathways and pharmacological agents (English)

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2 September 2017

Elise Saunier

1

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2 September 2017

Chantal Benelli

series ordinal

2

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2 September 2017

Sylvie Bortoli

series ordinal

3

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2 September 2017

language of work or name

English

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publication date

13 April 2015

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International Journal of Cancer

2 September 2017

published in

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2 September 2017

volume

138

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2 September 2017

issue

4

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2 September 2017

page(s)

809-817

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

2 September 2017

cites work

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Role of dichloroacetate in the treatment of genetic mitochondrial diseases

21 January 2018

1 reference

Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells

21 January 2018

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Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

21 January 2018

1 reference

Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer

21 January 2018

1 reference

Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo

21 January 2018

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Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding and promotes the Warburg effect.

21 January 2018

1 reference

Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex

21 January 2018

1 reference

Pyruvate dehydrogenase kinase isoform 2 activity stimulated by speeding up the rate of dissociation of ADP

21 January 2018

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Comprehensive review on lactate metabolism in human health

21 January 2018

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Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites

21 January 2018

1 reference

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

21 January 2018

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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

21 January 2018

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Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance

21 January 2018

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p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2

21 January 2018

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Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer

21 January 2018

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Gene expressions and copy numbers associated with metastatic phenotypes of uterine cervical cancer

21 January 2018

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Overexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancer

21 January 2018

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Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex

21 January 2018

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Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation

21 January 2018

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Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism

21 January 2018

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A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

21 January 2018

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Glucose oxidation modulates anoikis and tumor metastasis.

21 January 2018

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A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.

21 January 2018

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Regulation of the PDK4 isozyme by the Rb-E2F1 complex

21 January 2018

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Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex

21 January 2018

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Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth

21 January 2018

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SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells.

21 January 2018

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SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways

21 January 2018

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Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops

21 January 2018

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Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands

21 January 2018

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Metabolic modulation of cancer: a new frontier with great translational potential

21 January 2018

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Mito-DCA: a mitochondria targeted molecular scaffold for efficacious delivery of metabolic modulator dichloroacetate

21 January 2018

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Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate

21 January 2018

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Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity

21 January 2018

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Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo

21 January 2018

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Structure of pyruvate dehydrogenase kinase. Novel folding pattern for a serine protein kinase

21 January 2018

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Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket

21 January 2018

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Discovery and optimization of 4,5-diarylisoxazoles as potent dual inhibitors of pyruvate dehydrogenase kinase and heat shock protein 90.

21 January 2018

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VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells

21 January 2018

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Phenylbutyrate therapy for pyruvate dehydrogenase complex deficiency and lactic acidosis.

21 January 2018

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Clinical and experimental applications of sodium phenylbutyrate

21 January 2018

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Activating oxidative phosphorylation by a pyruvate dehydrogenase kinase inhibitor overcomes sorafenib resistance of hepatocellular carcinoma

21 January 2018

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Energizing miRNA research: a review of the role of miRNAs in lipid metabolism, with a prediction that miR-103/107 regulates human metabolic pathways

21 January 2018

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Influence of metabolism on epigenetics and disease

21 January 2018

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Metabolic regulation of epigenetics

21 January 2018

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ATP-citrate lyase links cellular metabolism to histone acetylation

21 January 2018

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A nuclear pyruvate dehydrogenase complex is important for the generation of acetyl-CoA and histone acetylation

21 January 2018

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Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.29564

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2 September 2017

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