(Q38424752)

3 September 2017

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title

Type 2 cytokines: mechanisms and therapeutic strategies (English)

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3 September 2017

Thomas A Wynn

1

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3 September 2017

17 April 2015

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Nature Reviews Immunology

3 September 2017

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3 September 2017

15

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3 September 2017

5

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3 September 2017

271-282

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Functional diversity of helper T lymphocytes

3 September 2017

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IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis.

21 January 2018

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An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response

21 January 2018

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Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites

21 January 2018

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Muc5ac: a critical component mediating the rejection of enteric nematodes

21 January 2018

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Dependence of IL-4, IL-13, and nematode-induced alterations in murine small intestinal smooth muscle contractility on Stat6 and enteric nerves.

21 January 2018

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Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway.

21 January 2018

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IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion

21 January 2018

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Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis.

21 January 2018

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Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths.

21 January 2018

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Fibrotic disease and the T(H)1/T(H)2 paradigm

21 January 2018

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Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration.

21 January 2018

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Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis.

21 January 2018

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Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis

21 January 2018

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Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance

21 January 2018

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Macrophage biology in development, homeostasis and disease

21 January 2018

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21 January 2018

Allergic host defences

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Infection of mice with Mycobacterium bovis-Bacillus Calmette-Guérin (BCG) suppresses allergen-induced airway eosinophilia

21 January 2018

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Preexisting helminth infection induces inhibition of innate pulmonary anti-tuberculosis defense by engaging the IL-4 receptor pathway

21 January 2018

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Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation

21 January 2018

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T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis.

21 January 2018

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IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion

21 January 2018

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IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice

21 January 2018

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Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells

21 January 2018

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Coordinated regulation of myeloid cells by tumours

21 January 2018

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Evolution of Th2 immunity: a rapid repair response to tissue destructive pathogens.

21 January 2018

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Mechanisms of fibrosis: therapeutic translation for fibrotic disease

21 January 2018

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Diversity and dialogue in immunity to helminths.

21 January 2018

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New paradigms in type 2 immunity

21 January 2018

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Innate lymphoid cells--how did we miss them?

21 January 2018

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Plasticity of CD4+ T cell lineage differentiation.

21 January 2018

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How are T(H)2-type immune responses initiated and amplified?

21 January 2018

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Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells

21 January 2018

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Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells.

21 January 2018

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Cloning of a new cytokine that induces IFN-gamma production by T cells

21 January 2018

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Developmental commitment to the Th2 lineage by extinction of IL-12 signaling.

21 January 2018

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The adjuvant effect of interleukin-12 in a vaccine against Leishmania major.

21 January 2018

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Cytokine-mediated regulation of chronic intestinal helminth infection

21 January 2018

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Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites

21 January 2018

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Regulation of pathogenesis and immunity in helminth infections

21 January 2018

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TNF-α/IL-17 synergy inhibits IL-13 bioactivity via IL-13Rα2 induction

21 January 2018

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IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent

21 January 2018

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Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology

21 January 2018

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CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity

21 January 2018

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Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice

21 January 2018

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Immunostimulatory oligonucleotides block allergic airway inflammation by inhibiting Th2 cell activation and IgE-mediated cytokine induction

21 January 2018

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A limited CpG-containing oligodeoxynucleotide therapy regimen induces sustained suppression of allergic airway inflammation in mice.

21 January 2018

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Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.

21 January 2018

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Tumor-associated macrophages: from mechanisms to therapy

21 January 2018

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Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy.

21 January 2018

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Macrophage activation and polarization: nomenclature and experimental guidelines

21 January 2018

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Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells

21 January 2018

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Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity

21 January 2018

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Biology of lung dendritic cells at the origin of asthma

21 January 2018

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Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells.

21 January 2018

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Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response

21 January 2018

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MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity.

21 January 2018

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Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny

21 January 2018

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Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen

21 January 2018

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Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation

21 January 2018

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IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1

21 January 2018

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A restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure

21 January 2018

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Exploring the full spectrum of macrophage activation

21 January 2018

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Alternative activation of macrophages

21 January 2018

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Protective and pathogenic functions of macrophage subsets

21 January 2018

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The JAK-STAT signaling pathway: input and output integration

21 January 2018

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IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

21 January 2018

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The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

21 January 2018

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Interleukin-10 and the interleukin-10 receptor

21 January 2018

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Cutting edge: Stat6-dependent substrate depletion regulates nitric oxide production

21 January 2018

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Induction and stability of human Th17 cells require endogenous NOS2 and cGMP-dependent NO signaling

21 January 2018

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L-arginine metabolism in myeloid cells controls T-lymphocyte functions.

21 January 2018

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NOS-2 mediates the protective anti-inflammatory and antifibrotic effects of the Th1-inducing adjuvant, IL-12, in a Th2 model of granulomatous disease

21 January 2018

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Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens

21 January 2018

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Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology.

21 January 2018

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Incomplete deletion of IL-4Rα by LysM(Cre) reveals distinct subsets of M2 macrophages controlling inflammation and fibrosis in chronic schistosomiasis.

21 January 2018

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Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis

21 January 2018

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Arginine physiology and its implication for wound healing

21 January 2018

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Cationic amino acid transporter-2 regulates immunity by modulating arginase activity

21 January 2018

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Role of arginase 1 from myeloid cells in th2-dominated lung inflammation.

21 January 2018

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Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4.

21 January 2018

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Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung.

21 January 2018

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Retnla (relmalpha/fizz1) suppresses helminth-induced Th2-type immunity

21 January 2018

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IL-10 is critical for host resistance and survival during gastrointestinal helminth infection.

21 January 2018

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Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis

21 January 2018

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Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells

21 January 2018

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In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure

21 January 2018

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Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent.

21 January 2018

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A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells.

21 January 2018

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Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10

21 January 2018

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Early recruitment of natural CD4+ Foxp3+ Treg cells by infective larvae determines the outcome of filarial infection.

21 January 2018

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The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells.

21 January 2018

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Helminth infection protects mice from anaphylaxis via IL-10-producing B cells.

21 January 2018

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Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammation

21 January 2018

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Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation

21 January 2018

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In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.

21 January 2018

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Allergy, parasites, and the hygiene hypothesis

21 January 2018

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Suppression of TH2-type allergic reactions by helminth infection.

21 January 2018

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Helminth-derived immunomodulators: can understanding the worm produce the pill?

21 January 2018

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An enteric helminth infection protects against an allergic response to dietary antigen.

21 January 2018

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Suppression of allergic airway inflammation by helminth-induced regulatory T cells

21 January 2018

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A helminth immunomodulator reduces allergic and inflammatory responses by induction of IL-10-producing macrophages

21 January 2018

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Cytokine signaling modules in inflammatory responses

21 January 2018

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SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses

21 January 2018

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Suppressor of cytokine signaling-1 is an IL-4-inducible gene in macrophages and feedback inhibits IL-4 signaling.

21 January 2018

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Suppressor of cytokine signalling 1 (SOCS1) is a physiological regulator of the asthma response

21 January 2018

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Expression of SOCS1 and SOCS3 is altered in the nasal mucosa of patients with mild and moderate/severe persistent allergic rhinitis.

21 January 2018

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Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1

21 January 2018

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The control of allergic conjunctivitis by suppressor of cytokine signaling (SOCS)3 and SOCS5 in a murine model

21 January 2018

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Gene silencing of SOCS3 by siRNA intranasal delivery inhibits asthma phenotype in mice

21 January 2018

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Interleukin-4 and interleukin-13 signaling connections maps

21 January 2018

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Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis

21 January 2018

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Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system

21 January 2018

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Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2.

21 January 2018

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Molecular Basis for Shared Cytokine Recognition Revealed in the Structure of an Unusually High Affinity Complex between IL-13 and IL-13Rα2

21 January 2018

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Opposing roles for IL-13 and IL-13 receptor alpha 2 in health and disease

21 January 2018

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Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response

21 January 2018

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IL-13 receptor alpha 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis

21 January 2018

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Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling

21 January 2018

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Functional importance of regional differences in localized gene expression of receptors for IL-13 in murine gut.

21 January 2018

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IL-13 receptor alpha2 regulates the immune and functional response to Nippostrongylus brasiliensis infection

21 January 2018

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Lysophosphatidic acid induces interleukin-13 (IL-13) receptor alpha2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cells

21 January 2018

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IL-13 receptor alpha 2: a regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts

21 January 2018

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IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice

21 January 2018

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IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung.

21 January 2018

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Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity.

21 January 2018

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IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization

21 January 2018

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Colitis and intestinal inflammation in IL10-/- mice results from IL-13Rα2-mediated attenuation of IL-13 activity.

21 January 2018

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Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection

21 January 2018

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Accelerated and progressive and lethal liver fibrosis in mice that lack interleukin (IL)-10, IL-12p40, and IL-13Rα2.

21 January 2018

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Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent

21 January 2018

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Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain

21 January 2018

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Role of periostin, FENO, IL-13, lebrikzumab, other IL-13 antagonist and dual IL-4/IL-13 antagonist in asthma

21 January 2018

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Toward a new generation of vaccines: the anti-cytokine therapeutic vaccines

21 January 2018

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Anti-IL-9 vaccination prevents worm expulsion and blood eosinophilia in Trichuris muris-infected mice.

21 January 2018

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Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma

21 January 2018

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Dupilumab in persistent asthma with elevated eosinophil levels

21 January 2018

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Lebrikizumab treatment in adults with asthma

21 January 2018

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Eosinophils: changing perspectives in health and disease

21 January 2018

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TH2, allergy and group 2 innate lymphoid cells

21 January 2018

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Eosinophils in asthma--closing the loop or opening the door?

21 January 2018

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Interleukin-5 (IL-5) augments the progression of liver fibrosis by regulating IL-13 activity.

21 January 2018

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Schistosoma mansoni infection in eosinophil lineage-ablated mice

21 January 2018

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IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo

21 January 2018

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Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP.

21 January 2018

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IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines

21 January 2018

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The influence of TSLP on the allergic response

21 January 2018

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Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33.

21 January 2018

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TSLP promotes induction of Th2 differentiation but is not necessary during established allergen-induced pulmonary disease

21 January 2018

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Regulation of helminth-induced Th2 responses by thymic stromal lymphopoietin

21 January 2018

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IL-33 is a crucial amplifier of innate rather than acquired immunity

21 January 2018

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Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function

21 January 2018

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Effects of an anti-TSLP antibody on allergen-induced asthmatic responses

21 January 2018

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T cell homing to epithelial barriers in allergic disease

21 January 2018

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Immunological mechanisms of allergen-specific immunotherapy

21 January 2018

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The role of prostaglandins in allergic lung inflammation and asthma

21 January 2018

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Helminth therapy or elimination: epidemiological, immunological, and clinical considerations

21 January 2018

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Type 2 inflammation in asthma--present in most, absent in many

21 January 2018

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Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.

21 January 2018

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An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection

21 January 2018

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Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1

21 January 2018

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TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties

21 January 2018

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Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion

31 March 2020

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Interleukin 4 in inflammatory bowel disease and mucosal immune reactivity

31 March 2020

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IL-18 deficiency selectively enhances allergen-induced eosinophilia in mice

31 March 2020

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CpG oligonucleotides can prophylactically immunize against Th2-mediated schistosome egg-induced pathology by an IL-12-independent mechanism

31 March 2020

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Reciprocal control of T helper cell and dendritic cell differentiation

31 March 2020

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Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis

31 March 2020

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IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis

31 March 2020

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Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repair

31 March 2020

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Allergic airway disease is unaffected by the absence of IL-4Rα-dependent alternatively activated macrophages

31 March 2020

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Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion

31 March 2020

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Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen

31 March 2020

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Exacerbation of experimental allergic asthma by augmented Th2 responses in WSX-1-deficient mice

31 March 2020

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The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity

31 March 2020

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The negative-feedback regulation of the IL-13 signal by the IL-13 receptor alpha2 chain in bronchial epithelial cells

31 March 2020

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IL-10 reduces Th2 cytokine production and eosinophilia but augments airway reactivity in allergic mice

31 March 2020

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Daclizumab improves asthma control in patients with moderate to severe persistent asthma: a randomized, controlled trial

31 March 2020

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Role of monocyte chemoattractant protein-1 (MCP-1) in Th1 (mycobacterial) and Th2 (schistosomal) antigen-induced granuloma formation: relationship to local inflammation, Th cell expression, and IL-12 production

31 March 2020

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12 December 2020

The M1 and M2 paradigm of macrophage activation: time for reassessment

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12 December 2020

Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production

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12 December 2020

Production of IL-10 by CD4+ T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection

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12 December 2020

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells

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12 December 2020

Temporal expression of different pathways of 1-arginine metabolism in healing wounds

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12 December 2020

Inhibition of allergic airway inflammation in mice lacking nitric oxide synthase 2

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12 December 2020

IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease

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12 December 2020

Identifiers

DOI

10.1038/NRI3831

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3 September 2017

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PubMed ID

25882242