(Q38597446)

4 September 2017

Identification of drug candidates and repurposing opportunities through compound-target interaction networks (English)

1 reference

4 September 2017

Anna Cichonska

1

0 references

Tero Aittokallio

object named as

Tero Aittokallio

series ordinal

3

0 references

Juho Rousu

series ordinal

2

object named as

Juho Rousu

1 reference

PubMed ID

26429153

4 September 2017

language of work or name

English

0 references

publication date

1 October 2015

1 reference

Expert Opinion on Drug Discovery

4 September 2017

1 reference

4 September 2017

10

1 reference

4 September 2017

12

1 reference

4 September 2017

1333-1345

1 reference

Diagnosing the decline in pharmaceutical R&D efficiency

4 September 2017

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Conciliating binding efficiency and polypharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Polypharmacology - foe or friend?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Unveiling the role of network and systems biology in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Network approaches to drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Network-based strategies can help mono- and poly-pharmacology drug discovery: a systems biology view

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Maximizing computational tools for successful drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

High-throughput methods for combinatorial drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Network pharmacology: the next paradigm in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Network pharmacology strategies toward multi-target anticancer therapies: from computational models to experimental design principles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

A network view of disease and compound screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Network systems biology for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Best Practices for QSAR Model Development, Validation, and Exploitation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

A community effort to assess and improve drug sensitivity prediction algorithms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Predicting in vitro drug sensitivity using Random Forests

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Kernelized Bayesian Matrix Factorization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Chemogenomic approaches to infer drug-target interaction networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Drug-target interaction prediction via chemogenomic space: learning-based methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Comprehensive analysis of kinase inhibitor selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

21 January 2018

Navigating the kinome

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Tracking cancer drugs in living cells by thermal profiling of the proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Mass spectrometry-based proteomics in preclinical drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Exploring chemical space for drug discovery using the chemical universe database

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Making sense of large-scale kinase inhibitor bioactivity data sets: a comparative and integrative analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

UniChem: a unified chemical structure cross-referencing and identifier tracking system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Gaussian interaction profile kernels for predicting drug-target interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Predicting Drug-Target Interactions for New Drug Compounds Using a Weighted Nearest Neighbor Profile

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Prediction of drug-target interactions and drug repositioning via network-based inference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Prediction of chemical-protein interactions network with weighted network-based inference method

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Predicting drug-target interactions using restricted Boltzmann machines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Relating protein pharmacology by ligand chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Predicting new molecular targets for known drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Prediction of drug-target interaction networks from the integration of chemical and genomic spaces.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Supervised prediction of drug-target interactions using bipartite local models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Drug-target interaction prediction from chemical, genomic and pharmacological data in an integrated framework

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Drug-target interaction prediction through domain-tuned network-based inference.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Drug-target interaction prediction by random walk on the heterogeneous network.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Drug repositioning by integrating target information through a heterogeneous network model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Drug target identification using side-effect similarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Identification of small molecules enhancing autophagic function from drug network analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Network-based relating pharmacological and genomic spaces for drug target identification

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Finding the targets of a drug by integration of gene expression data with a protein interaction network

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Combining drug and gene similarity measures for drug-target elucidation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Enhancing the prioritization of disease-causing genes through tissue specific protein interaction networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Construction and analyses of human large-scale tissue specific networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Understanding multicellular function and disease with human tissue-specific networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Elucidating Compound Mechanism of Action by Network Perturbation Analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Validating therapeutic targets through human genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

The support of human genetic evidence for approved drug indications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Mining drug-disease relationships as a complement to medical genetics-based drug repositioning: Where a recommendation system meets genome-wide association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Selecting causal genes from genome-wide association studies via functionally coherent subnetworks

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Towards structural systems pharmacology to study complex diseases and personalized medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Opportunities for drug repositioning from phenome-wide association studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Rational drug repositioning by medical genetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Distribution and medical impact of loss-of-function variants in the Finnish founder population

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

RNA interference technology for anti-VEGF treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Pharmacogenomics in clinical practice and drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Cancer pharmacogenomics: strategies and challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Integrative and personalized QSAR analysis in cancer by kernelized Bayesian matrix factorization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Toward more realistic drug-target interaction predictions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Preclinical target validation using patient-derived cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

The ChEMBL bioactivity database: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

DrugBank 4.0: shedding new light on drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

STITCH 4: integration of protein-chemical interactions with user data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Data, information, knowledge and principle: back to metabolism in KEGG

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

PUG-SOAP and PUG-REST: web services for programmatic access to chemical information in PubChem

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

BRENDA in 2015: exciting developments in its 25th year of existence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

DGIdb: mining the druggable genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Therapeutic target database update 2014: a resource for targeted therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

ZINC: a free tool to discover chemistry for biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

Use of genome-wide association studies for drug repositioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2015.1096926

SuperTarget and Matador: resources for exploring drug-target relationships

21 January 2018

1 reference

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Conditional UAS-targeted repression in Drosophila

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Connecting gene expression data from connectivity map and in silico target predictions for small molecule mechanism-of-action analysis.

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An Integrated Approach to Anti-Cancer Drug Sensitivity Prediction

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Discovery of drug mode of action and drug repositioning from transcriptional responses

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Identifiers

DOI

10.1517/17460441.2015.1096926

1 reference

4 September 2017

1 reference

PubMed ID

26429153