(Q38605937)

9 January 2018

title

Dysfunction of the MDM2/p53 axis is linked to premature aging (English)

1 reference

9 January 2018

15

Gudrun Nürnberg

0 references

Christian Kubisch

24

Christian Kubisch

0 references

Peter Nürnberg

16

Peter Nürnberg

1 reference

PMCID

5617664

9 January 2018

Matthias Hammerschmidt

17

Matthias Hammerschmidt

1 reference

9 January 2018

Carol Prives

23

Carol Prives

1 reference

9 January 2018

Josef Högel

13

Josef Högel

1 reference

9 January 2018

Holger Thiele

14

Holger Thiele

1 reference

9 January 2018

author name string

Davor Lessel

1

1 reference

9 January 2018

Danyi Wu

2

1 reference

9 January 2018

Carlos Trujillo

3

1 reference

9 January 2018

Thomas Ramezani

4

1 reference

9 January 2018

Ivana Lessel

5

1 reference

9 January 2018

Mohammad K Alwasiyah

6

1 reference

9 January 2018

Bidisha Saha

7

1 reference

9 January 2018

Fuki M Hisama

8

1 reference

9 January 2018

Katrin Rading

9

1 reference

9 January 2018

Ingrid Goebel

10

1 reference

9 January 2018

Petra Schütz

11

1 reference

9 January 2018

Günter Speit

12

1 reference

9 January 2018

Yan Zhu

18

1 reference

9 January 2018

David R Tong

19

1 reference

9 January 2018

Chen Katz

20

1 reference

9 January 2018

George M Martin

21

1 reference

9 January 2018

Junko Oshima

22

1 reference

9 January 2018

language of work or name

English

0 references

publication date

28 August 2017

1 reference

9 January 2018

Journal of Clinical Investigation

published in

1 reference

9 January 2018

volume

127

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9 January 2018

issue

10

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9 January 2018

page(s)

3598-3608

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9 January 2018

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5617664/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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23 June 2018

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POLD1 Germline Mutations in Patients Initially Diagnosed with Werner Syndrome

23 June 2018

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23 June 2018

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Regulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damage

23 June 2018

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Unravelling mechanisms of p53-mediated tumour suppression

23 June 2018

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Drugging the p53 pathway: understanding the route to clinical efficacy

23 June 2018

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Mdm2 is required for maintenance of the nephrogenic niche

23 June 2018

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The MDM2-p53 pathway: multiple roles in kidney development.

23 June 2018

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23 June 2018

The hallmarks of aging

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Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy

23 June 2018

1 reference

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p38 (MAPK) stress signalling in replicative senescence in fibroblasts from progeroid and genomic instability syndromes

23 June 2018

1 reference

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p53 dynamics control cell fate

23 June 2018

1 reference

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Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

Puma is required for p53-induced depletion of adult stem cells

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

Using mice to examine p53 functions in cancer, aging, and longevity

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

The p53 orchestra: Mdm2 and Mdmx set the tone

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

Stem cells: The promises and perils of p53.

23 June 2018

1 reference

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The multiple levels of regulation by p53 ubiquitination

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

HomozygosityMapper--an interactive approach to homozygosity mapping

23 June 2018

1 reference

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Blinded by the Light: The Growing Complexity of p53

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

Aging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability, localization, and activity

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

Tumor suppressor p53 Arg72Pro polymorphism and longevity, cancer survival, and risk of cancer in the general population

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

p53 in health and disease

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

Coping with stress: multiple ways to activate p53.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

An essential function of the extreme C-terminus of MDM2 can be provided by MDMX

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

The spectrum of WRN mutations in Werner syndrome patients

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

Lamin A-dependent nuclear defects in human aging

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

Tumor suppression and normal aging in mice with constitutively high p53 activity

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

Variation in the human TP53 gene affects old age survival and cancer mortality.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

Modulation of mammalian life span by the short isoform of p53.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

Zebrafish as a model organism for the identification and characterization of drugs and genes affecting p53 signaling

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

p53 mutant mice that display early ageing-associated phenotypes

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

23 June 2018

Surfing the p53 network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

mdm2 expression is induced by wild type p53 activity

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

The p53-mdm-2 autoregulatory feedback loop

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

Increased p53 protein associated with aging in human diploid fibroblasts

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

Genetic syndromes in man with potential relevance to the pathobiology of aging

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

MDM2 (murine double minute-2) links inflammation and tubular cell healing during acute kidney injury in mice.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

CSA and CSB proteins interact with p53 and regulate its Mdm2-dependent ubiquitination.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

P53 and aging: A fresh look at an old paradigm

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

Genetic modeling of Li-Fraumeni syndrome in zebrafish

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

Fragile fugue: p53 in aging, cancer and IGF signaling.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

Apoptosis in the developing zebrafish embryo.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

Delayed ageing through damage protection by the Arf/p53 pathway

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5617664

3 December 2018

Identifiers

DOI

10.1172/JCI92171

1 reference

9 January 2018

PMCID

5617664

1 reference

9 January 2018

PubMed ID

28846075

1 reference

9 January 2018