(Q38625953)

20 February 2018

title

SAM/SAH Analogs as Versatile Tools for SAM-Dependent Methyltransferases (English)

1 reference

20 February 2018

author name string

Jing Zhang

series ordinal

1

1 reference

20 February 2018

Yujun George Zheng

series ordinal

2

1 reference

20 February 2018

publication date

5 November 2015

1 reference

20 February 2018

published in

ACS Chemical Biology

1 reference

20 February 2018

volume

11

1 reference

20 February 2018

issue

3

1 reference

20 February 2018

page(s)

583-597

1 reference

20 February 2018

Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond

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23 June 2018

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Selenium-based S-adenosylmethionine analog reveals the mammalian seven-beta-strand methyltransferase METTL10 to be an EF1A1 lysine methyltransferase

23 June 2018

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Primary acute myeloid leukemia cells with IDH1 or IDH2 mutations respond to a DOT1L inhibitor in vitro

23 June 2018

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Analogues of the Natural Product Sinefungin as Inhibitors of EHMT1 and EHMT2.

23 June 2018

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DOT1L inhibition sensitizes MLL-rearranged AML to chemotherapy

23 June 2018

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Large-scale, protection-free synthesis of Se-adenosyl-L-selenomethionine analogues and their application as cofactor surrogates of methyltransferases

23 June 2018

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Emerging technologies to map the protein methylome.

23 June 2018

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Epigenetic targets and drug discovery: part 1: histone methylation.

23 June 2018

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Cancer epigenetics drug discovery and development: the challenge of hitting the mark

23 June 2018

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Profiling substrates of protein arginine N-methyltransferase 3 with S-adenosyl-L-methionine analogues

23 June 2018

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NRMT2 is an N-terminal monomethylase that primes for its homologue NRMT1.

23 June 2018

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Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation

23 June 2018

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A journey toward Bioorthogonal Profiling of Protein Methylation inside living cells

23 June 2018

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DNA methyltransferase inhibitors and their emerging role in epigenetic therapy of cancer

23 June 2018

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A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L.

23 June 2018

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Targeted drug discovery for pediatric leukemia

23 June 2018

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Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

23 June 2018

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Synthesis, Activity and Metabolic Stability of Non-Ribose Containing Inhibitors of Histone Methyltransferase DOT1L.

23 June 2018

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Profiling protein methylation with cofactor analog containing terminal alkyne functionality

23 June 2018

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Structure-based drug design of catechol-O-methyltransferase inhibitors for CNS disorders

23 June 2018

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Bioorthogonal profiling of protein methylation (BPPM) using an azido analog of S-adenosyl-L-methionine

23 June 2018

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Enhanced chemical stability of adomet analogues for improved methyltransferase-directed labeling of DNA.

23 June 2018

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Bromo-deaza-SAH: a potent and selective DOT1L inhibitor

23 June 2018

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Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

23 June 2018

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Profiling genome-wide chromatin methylation with engineered posttranslation apparatus within living cells

23 June 2018

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S-adenosyl-methionine-dependent methyltransferases: highly versatile enzymes in biocatalysis, biosynthesis and other biotechnological applications.

23 June 2018

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Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2

23 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Engineering the DNA cytosine-5 methyltransferase reaction for sequence-specific labeling of DNA

23 June 2018

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Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1L

23 June 2018

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Synthesis and structure-activity relationship investigation of adenosine-containing inhibitors of histone methyltransferase DOT1L

23 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Se-adenosyl-L-selenomethionine cofactor analogue as a reporter of protein methylation

23 June 2018

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A systematic review of catechol-0-methyltransferase inhibitors: efficacy and safety in clinical practice.

23 June 2018

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Chemical and biochemical approaches in the study of histone methylation and demethylation

23 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Role of catechol-O-methyltransferase (COMT)-dependent processes in Parkinson's disease and L-DOPA treatment

23 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Bioorthogonal profiling of protein methylation using azido derivative of S-adenosyl-L-methionine

23 June 2018

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Chromatin-modifying enzymes as modulators of reprogramming

23 June 2018

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Current chemical biology approaches to interrogate protein methyltransferases

23 June 2018

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Epigenetic drug discovery: targeting DNA methyltransferases

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Structure-guided design of a methyl donor cofactor that controls a viral histone H3 lysine 27 methyltransferase activity

23 June 2018

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Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies

23 June 2018

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Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

23 June 2018

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Chemogenetic analysis of human protein methyltransferases

23 June 2018

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Labeling substrates of protein arginine methyltransferase with engineered enzymes and matched S-adenosyl-L-methionine analogues

23 June 2018

1 reference

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Molecular recognition at the active site of catechol-O-methyltransferase (COMT): adenine replacements in bisubstrate inhibitors

23 June 2018

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Expanding cofactor repertoire of protein lysine methyltransferase for substrate labeling

23 June 2018

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A chemical method for labeling lysine methyltransferase substrates.

23 June 2018

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Profiling of methyltransferases and other S-adenosyl-L-homocysteine-binding Proteins by Capture Compound Mass Spectrometry (CCMS).

23 June 2018

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Development of novel bisubstrate-type inhibitors of histone methyltransferase SET7/9.

23 June 2018

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NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein

23 June 2018

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Enhanced interrogation: emerging strategies for cell signaling inhibition

23 June 2018

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Identification of protein N-terminal methyltransferases in yeast and humans

23 June 2018

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Toward the development of potent and selective bisubstrate inhibitors of protein arginine methyltransferases.

23 June 2018

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Enzyme-catalyzed transfer of a ketone group from an S-adenosylmethionine analogue: a tool for the functional analysis of methyltransferases

23 June 2018

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Synthesis of S-adenosyl-L-homocysteine capture compounds for selective photoinduced isolation of methyltransferases

23 June 2018

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Molecular recognition at the active site of catechol-o-methyltransferase: energetically favorable replacement of a water molecule imported by a bisubstrate inhibitor

23 June 2018

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Protein methyltransferases as a target class for drug discovery

23 June 2018

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S-adenosyl-N-decyl-aminoethyl, a potent bisubstrate inhibitor of mycobacterium tuberculosis mycolic acid methyltransferases

23 June 2018

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Chemical probes for histone-modifying enzymes

23 June 2018

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Chemical regulation of epigenetic modifications: opportunities for new cancer therapy.

23 June 2018

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SnapShot: Histone-modifying enzymes

23 June 2018

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Catechol-O-methyltransferase and its inhibitors in Parkinson's disease

23 June 2018

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Capture compound mass spectrometry: a technology for the investigation of small molecule protein interactions

23 June 2018

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Bisubstrate inhibitors of catechol O-methyltransferase (COMT): the crucial role of the ribose structural unit for inhibitor binding affinity

23 June 2018

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S-adenosylmethionine: jack of all trades and master of everything?

23 June 2018

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Natural product diversification using a non-natural cofactor analogue of S-adenosyl-L-methionine.

23 June 2018

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DNA methyltransferase inhibitors and the development of epigenetic cancer therapies

23 June 2018

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Conversion of DNA methyltransferases into azidonucleosidyl transferases via synthetic cofactors

23 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

23 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

S-adenosylmethionine: nothing goes to waste

23 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Many paths to methyltransfer: a chronicle of convergence

23 June 2018

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S-Adenosylmethionine: a wolf in sheep's clothing, or a rich man's adenosylcobalamin?

23 June 2018

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Design of a new fluorescent cofactor for DNA methyltransferases and sequence-specific labeling of DNA.

23 June 2018

1 reference

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SAM (dependent) I AM: the S-adenosylmethionine-dependent methyltransferase fold

23 June 2018

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Beyond Watson and Crick: DNA methylation and molecular enzymology of DNA methyltransferases

23 June 2018

1 reference

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Structure-based design, synthesis, and in vitro evaluation of bisubstrate inhibitors for catechol O-methyltransferase (COMT).

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Trends in the biochemical pharmacology of 5'-deoxy-5'-methylthioadenosine

23 June 2018

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Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 2. Modification of the base portion of S-adenosylhomocysteine

23 June 2018

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Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 1. Modification of the amino acid portion of S-adenosylhomocysteine

23 June 2018

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Analogs of S-adenosylhomocysteine as potential inhibitors of biological transmethylation. Specificity of the S-adenosylhomocysteine binding site

23 June 2018

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[New syntheses of S-adenosyl homocysteine analogues, potential methyltransferase inhibitors].

23 June 2018

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Chromatographic analysis of the chiral and covalent instability of S-adenosyl-L-methionine

23 June 2018

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Synthesis of some novel potent and selective catechol O-methyltransferase inhibitors

23 June 2018

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Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Analogues of S-adenosylhomocysteine as potential inhibitors of biological transmethylation. Synthesis of analogues with modifications at the 5'-thioether linkage

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 3. Modifications of the sugar portion of S-adenosylhomocysteine

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 6. Structural modifications of S-adenosylmethionine

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Regulation of Wnt signaling target gene expression by the histone methyltransferase DOT1L.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Profiling of methyltransferases and other S-Adenosyl-L-homocysteine-binding proteins by Capture Compound mass spectrometry.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Small molecule inhibitors that discriminate between protein arginine N-methyltransferases PRMT1 and CARM1.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Formulating a fluorogenic assay to evaluate S-adenosyl-L-methionine analogues as protein methyltransferase cofactors

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Expanding the chemical scope of RNA:methyltransferases to site-specific alkynylation of RNA for click labeling

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Enzymatic stereospecific preparation of fluorescent S-adenosyl-L-methionine analogs.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

New S-adenosyl-L-methionine analogues: synthesis and reactivity studies.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Activation and inhibition of DNA methyltransferases by S-adenosyl-L-homocysteine analogues

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Methyltransferase-directed DNA strand scission

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Isotope and elemental effects indicate a rate-limiting methyl transfer as the initial step in the reaction catalyzed by Escherichia coli cyclopropane fatty acid synthase

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Insight into the polar reactivity of the onium chalcogen analogues of S-adenosyl-L-methionine

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Bisubstrate inhibitors for the enzyme catechol-O-methyltransferase (COMT): influence of inhibitor preorganisation and linker length between the two substrate moieties on binding affinity

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Design of allele-specific protein methyltransferase inhibitors

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Mechanism-based inhibition of an essential bacterial adenine DNA methyltransferase: rationally designed antibiotics

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Mutational Analysis ofEncephalitozoon cuniculimRNA Cap (Guanine-N7) Methyltransferase, Structure of the Enzyme Bound to Sinefungin, and Evidence That Cap Methyltransferase Is the Target of Sinefungin's Antifungal Activity

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Bisubstrate Inhibitors of the Enzyme Catechol O-Methyltransferase (COMT): Efficient Inhibition Despite the Lack of a Nitro Group

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5772741

Synthesis of S-adenosyl-L-methionine analogs and their use for sequence-specific transalkylation of DNA by methyltransferases

3 December 2018

1 reference

12 December 2020

A new tool for biotechnology: AdoMet-dependent methyltransferases

1 reference

12 December 2020

In situ generation of a bisubstrate analogue for protein arginine methyltransferase 1

1 reference

12 December 2020

Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 5. Role of the asymmetric sulfonium pole in the enzymatic binding of S-adenosyl-L-methionine

1 reference

12 December 2020

Targeted labeling of DNA by methyltransferase-directed transfer of activated groups (mTAG)

1 reference

12 December 2020

Enzymatic site-specific functionalization of protein methyltransferase substrates with alkynes for click labeling

1 reference

12 December 2020

Development of rationally designed DNA N6 adenine methyltransferase inhibitors

1 reference

12 December 2020

Fluorescent DNA Labeling by N-Mustard Analogues ofS-Adenosyl-L-Methionine

1 reference

12 December 2020

Inhibition of bacterial DNA cytosine-5-methyltransferase by S-adenosyl-l-homocysteine and some related compounds

1 reference

12 December 2020

DNA methyltransferase-moderated click chemistry

1 reference

12 December 2020

The stability and hydrolysis of S-adenosylmethionine; isolation of S-ribosylmethionine

1 reference

12 December 2020

A selenium-based click AdoMet analogue for versatile substrate labeling with wild-type protein methyltransferases

1 reference

12 December 2020

Synthesis and evaluation of protein arginine N-methyltransferase inhibitors designed to simultaneously occupy both substrate binding sites

1 reference

12 December 2020

Direct transfer of extended groups from synthetic cofactors by DNA methyltransferases

1 reference

12 December 2020

Sinefungin, a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication

1 reference

12 December 2020

Design, synthesis, and preliminary biological evaluation of a DNA methyltransferase-directed alkylating agent

1 reference

12 December 2020

10.1021/ACSCHEMBIO.5B00812

Identifiers

DOI

1 reference

20 February 2018

PMC publication ID

5772741

1 reference

20 February 2018

PubMed publication ID

26540123

1 reference

20 February 2018