(Q38666170)

5 September 2017

title

HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond (English)

1 reference

5 September 2017

Patrick H Maxwell

1

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Kai-Uwe Eckardt

series ordinal

2

object named as

Kai-Uwe Eckardt

1 reference

5 September 2017

language of work or name

English

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publication date

14 December 2015

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Nature Reviews Nephrology

5 September 2017

published in

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5 September 2017

volume

12

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5 September 2017

issue

3

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5 September 2017

page(s)

157-168

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https://scigraph.springernature.com/pub.10.1038/nrneph.2015.193

5 September 2017

exact match

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cites work

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21 January 2018

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High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq.

21 January 2018

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Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways.

21 January 2018

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Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor

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Identification of the renal erythropoietin-producing cells using transgenic mice

21 January 2018

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Repression via the GATA box is essential for tissue-specific erythropoietin gene expression.

21 January 2018

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Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys

21 January 2018

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Renal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cysts

21 January 2018

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HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner

21 January 2018

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A gain-of-function mutation in the HIF2A gene in familial erythrocytosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2 alpha mutation.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Sequencing of 50 human exomes reveals adaptation to high altitude

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

21 January 2018

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21 January 2018

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The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism

21 January 2018

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Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2

21 January 2018

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

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21 January 2018

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HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques

21 January 2018

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Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects

21 January 2018

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The interstitial response to renal injury: Fibroblast–like cells show phenotypic changes and have reduced potential for erythropoietin gene expression

21 January 2018

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Plasticity of renal erythropoietin-producing cells governs fibrosis.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Indoxyl sulfate, a representative uremic toxin, suppresses erythropoietin production in a HIF-dependent manner

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Oral adsorbent AST-120 potentiates the effect of erythropoietin-stimulating agents on Stage 5 chronic kidney disease patients: a randomized crossover study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Effect of altitude on erythropoiesis and oxygen affinity in anaemic patients on maintenance dialysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

The effect of altitude on dosing and response to erythropoietin in ESRD

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Anemia and erythrocytosis in patients after kidney transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Erythropoietin in polycystic kidneys

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Erythrocytosis in patients on long-term hemodialysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Involvement of hypoxia-inducible transcription factors in polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Hypoxia-inducible factor-1α causes renal cyst expansion through calcium-activated chloride secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Age-dependent expression of the erythropoietin gene in rat liver and kidneys

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Specific contribution of the erythropoietin gene 3' enhancer to hepatic erythropoiesis after late embryonic stages

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Reactivation of hepatic EPO synthesis in mice after PHD loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

MicroRNA-687 Induced by Hypoxia-Inducible Factor-1 Targets Phosphatase and Tensin Homolog in Renal Ischemia-Reperfusion Injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

New insights into iron regulation and erythropoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Hypoxia-inducible factors link iron homeostasis and erythropoiesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs).

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Erythropoietin's inhibiting impact on hepcidin expression occurs indirectly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Short-term treatment with a novel HIF-prolyl hydroxylase inhibitor (GSK1278863) failed to improve measures of performance in subjects with claudication-limited peripheral artery disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

VHL, the story of a tumour suppressor gene

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Mutations of the VHL tumour suppressor gene in renal carcinoma

21 January 2018

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Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron

21 January 2018

1 reference

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Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

21 January 2018

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

21 January 2018

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pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Regulation of angiogenesis by hypoxia: role of the HIF system

21 January 2018

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Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases

21 January 2018

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The hypoxia factor Hif-1α controls neural crest chemotaxis and epithelial to mesenchymal transition

21 January 2018

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Regulation of E-cadherin expression by VHL and hypoxia-inducible factor.

21 January 2018

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Molecular mechanisms mediating metastasis of hypoxic breast cancer cells

21 January 2018

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Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Novel exon 12 mutations in the HIF2A gene associated with erythrocytosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Mutation of von Hippel-Lindau tumour suppressor and human cardiopulmonary physiology

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice.

21 January 2018

1 reference

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Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors

21 January 2018

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Smooth muscle cell-specific Hif-1α deficiency suppresses angiotensin II-induced vascular remodelling in mice.

21 January 2018

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Hypoxia is present in murine atherosclerotic plaques and has multiple adverse effects on macrophage lipid metabolism

21 January 2018

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Cobalt promotes angiogenesis via hypoxia-inducible factor and protects tubulointerstitium in the remnant kidney model.

21 January 2018

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Induction of protective genes by cobalt ameliorates tubulointerstitial injury in the progressive Thy1 nephritis

21 January 2018

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Activation of hypoxia-inducible factor attenuates renal injury in rat remnant kidney

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Myeloid cell-derived hypoxia-inducible factor attenuates inflammation in unilateral ureteral obstruction-induced kidney injury

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Activation of hypoxia-inducible factors prevents diabetic nephropathy

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Randomized placebo-controlled dose-ranging and pharmacodynamics study of roxadustat (FG-4592) to treat anemia in nondialysis-dependent chronic kidney disease (NDD-CKD) patients

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

The challenge of translating ischemic conditioning from animal models to humans: the role of comorbidities

21 January 2018

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Hypoxic preconditioning protection is eliminated in HIF-1α knockout mice subjected to neonatal hypoxia-ischemia

21 January 2018

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Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning

21 January 2018

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HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice

21 January 2018

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Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore.

21 January 2018

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Short hairpin RNA gene silencing of prolyl hydroxylase-2 with a minicircle vector improves neovascularization of hindlimb ischemia.

21 January 2018

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Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

21 January 2018

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Induction of renoprotective gene expression by cobalt ameliorates ischemic injury of the kidney in rats

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

The protective effect of prolyl-hydroxylase inhibition against renal ischaemia requires application prior to ischaemia but is superior to EPO treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model

21 January 2018

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Erythropoietin and organ protection: lessons from negative clinical trials

21 January 2018

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Hypoxic signaling during tissue repair and regenerative medicine

21 January 2018

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Effect of human erythropoietin derived from recombinant DNA on the anaemia of patients maintained by chronic haemodialysis

21 January 2018

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Correction of anemia with epoetin alfa in chronic kidney disease

31 March 2020

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Co-localization of erythropoietin mRNA and ecto-5'-nucleotidase immunoreactivity in peritubular cells of rat renal cortex indicates that fibroblasts produce erythropoietin

31 March 2020

1 reference

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Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analogue N-oxaloglycine and its derivatives

31 March 2020

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Relation of serum erythropoietin levels to renal excretory function: evidence for lowered set point for erythropoietin production in chronic renal failure

31 March 2020

1 reference

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Erythropoietin-hematocrit feedback circuit in the anemia of end-stage renal disease

31 March 2020

1 reference

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Multiple site estimates of erythropoietin and renin in polycythemic kidney transplant patients.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Influence of serum hepatitis on haemoglobin level in patients on regular haemodialysis

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Hepatic regeneration and erythropoietin production in the rat

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Erythropoietin: structure, control of production, and function

31 March 2020

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Germ-line PHD1 and PHD2 mutations detected in patients with pheochromocytoma/paraganglioma-polycythemia

31 March 2020

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Dysregulation of the HIF pathway due to VHL mutation causing severe erythrocytosis and pulmonary arterial hypertension

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Roxadustat (FG-4592): Correction of Anemia in Incident Dialysis Patients

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Four-Week Studies of Oral Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitor GSK1278863 for Treatment of Anemia

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEPH.2015.193

Darbepoetin for the anaemia of chronic kidney disease

31 March 2020

1 reference

12 December 2020

Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition

1 reference

12 December 2020

Expression of a homologously recombined erythopoietin-SV40 T antigen fusion gene in mouse liver: evidence for erythropoietin production by Ito cells

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12 December 2020

Lessons learned from peginesatide in the treatment of anemia associated with chronic kidney disease in patients on dialysis

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12 December 2020

Erythropoiesis-stimulating agents for anaemia in adults with chronic kidney disease: a network meta-analysis

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12 December 2020

Localization of cells producing erythropoietin in murine liver by in situ hybridization

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12 December 2020

The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice.

1 reference

12 December 2020

HIF signaling pathway in pheochromocytoma and other neuroendocrine tumors

1 reference

12 December 2020

Partial identity of the 2-oxoglutarate and ascorbate binding sites of prolyl 4-hydroxylase

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRNEPH.2015.193

1 reference

Dimensions Publication ID

5 September 2017

1045801609

0 references

1 reference