(Q38715430)

5 September 2017

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title

Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies (English)

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5 September 2017

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David L Vaux

4

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Andreas Strasser

object named as

Andreas Strasser

series ordinal

3

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author name string

Alex R D Delbridge

series ordinal

1

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5 September 2017

Stephanie Grabow

series ordinal

2

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5 September 2017

language of work or name

English

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publication date

1 January 2016

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5 September 2017

published in

Nature Reviews Cancer

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5 September 2017

volume

16

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5 September 2017

issue

2

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5 September 2017

page(s)

99-109

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https://scigraph.springernature.com/pub.10.1038/nrc.2015.17

5 September 2017

exact match

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cites work

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The BCL-2 protein family, BH3-mimetics and cancer therapy

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Mechanisms of action of Bcl-2 family proteins

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Many players in BCL-2 family affairs

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Targeting the B-cell lymphoma/leukemia 2 family in cancer

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How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

31 March 2020

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Bcl-2 family members: dual regulators of apoptosis and autophagy

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2015.17

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

31 March 2020

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The molecular genetics of cellular oncogenes

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2015.17

Chromosome 14 translocations in non-burkitt lymphomas

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2015.17

Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2015.17

Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Malignant transformation of a growth factor-dependent myeloid cell line by Abelson virus without evidence of an autocrine mechanism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

The v-fms oncogene induces factor-independent growth and transformation of the interleukin-3-dependent myeloid cell line FDC-P1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Growth- and tumor-promoting effects of deregulated BCL2 in human B-lymphoblastoid cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2015.17

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2015.17

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) translocation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

The bcl-2 gene encodes a novel G protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Ultrastructural localization of bcl-2 protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Apoptotic cell death induced by c-myc is inhibited by bcl-2.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Oncogenic potential of bcl-2 demonstrated by gene transfer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Two CD95 (APO-1/Fas) signaling pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Post-embryonic cell lineages of the nematode, Caenorhabditis elegans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Genetic control of programmed cell death in the nematode C. elegans.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

The pathophysiology of mitochondrial cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Structural biology of the Bcl-2 family and its mimicry by viral proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

BID: a novel BH3 domain-only death agonist

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

BAX activation is initiated at a novel interaction site

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Bim: a novel member of the Bcl-2 family that promotes apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

PUMA, a novel proapoptotic gene, is induced by p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

NIX is required for programmed mitochondrial clearance during reticulocyte maturation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

BH3-only proteins: a 20-year stock-take

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Antagonism between MCL-1 and PUMA governs stem/progenitor cell survival during hematopoietic recovery from stress.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Mcl-1 is essential for the survival of plasma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Mcl-1 is essential for germinal center formation and B cell memory

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

ER stress triggers apoptosis by activating BH3-only protein Bim

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Bim is a suppressor of Myc-induced mouse B cell leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Genome-wide array-based CGH for mantle cell lymphoma: identification of homozygous deletions of the proapoptotic gene BIM.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Reversion of epigenetically mediated BIM silencing overcomes chemoresistance in Burkitt lymphoma.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

XIAP discriminates between type I and type II FAS-induced apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Cell-free apoptosis in Xenopus egg extracts: inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Inhibition of Bax channel-forming activity by Bcl-2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Structure of Bax: coregulation of dimer formation and intracellular localization

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

The structure of a Bcl-xL/Bim fragment complex: implications for Bim function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Shedding light on apoptosis at subcellular membranes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

miR-15 and miR-16 induce apoptosis by targeting BCL2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

The landscape of somatic copy-number alteration across human cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Prognostic significance of Bcl-xL gene expression in human colorectal cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Over-expression of bcl-xL gene in human gastric adenomas and carcinomas.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Bcl-xL is overexpressed in hormone-resistant prostate cancer and promotes survival of LNCaP cells via interaction with proapoptotic Bak.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

The let-7 family of microRNAs inhibits Bcl-xL expression and potentiates sorafenib-induced apoptosis in human hepatocellular carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

miR-193b Regulates Mcl-1 in Melanoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Evaluation and critical assessment of putative MCL-1 inhibitors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

BCL-2 family antagonists for cancer therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Different forms of cell death induced by putative BCL2 inhibitors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

The Bcl-2 inhibitor ABT-263 enhances the response of multiple chemotherapeutic regimens in hematologic tumors in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft models

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Programmed anuclear cell death delimits platelet life span.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Bcl-2 family proteins are essential for platelet survival.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Structure-guided design of a selective BCL-X(L) inhibitor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Phase 1 study of the safety, pharmacokinetics, and antitumour activity of the BCL2 inhibitor navitoclax in combination with rituximab in patients with relapsed or refractory CD20+ lymphoid malignancies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

ABT-199, a new Bcl-2-specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

ABT-737 induces apoptosis in mantle cell lymphoma cells with a Bcl-2high/Mcl-1low profile and synergizes with other antineoplastic agents

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

MCL-1 but not BCL-XL is critical for the development and sustained expansion of thymic lymphoma in p53-deficient mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Requirement for antiapoptotic MCL-1 in the survival of BCR-ABL B-lineage acute lymphoblastic leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

Integral role of Noxa in p53-mediated apoptotic response

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2015.17

The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane.

31 March 2020

1 reference

12 December 2020

Membrane topology of the Bcl-2 proto-oncogenic protein demonstrated in vitro.

1 reference

12 December 2020

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1 reference

12 December 2020

Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2

1 reference

12 December 2020

BCL2 overexpression associated with chromosomal amplification in diffuse large B-cell lymphoma

1 reference

12 December 2020

Mcl-1 deficiency results in peri-implantation embryonic lethality

1 reference

12 December 2020

Abnormalities of the immune system induced by dysregulated bcl-2 expression in transgenic mice

1 reference

12 December 2020

Accelerated disappearance of melanocytes in bcl-2-deficient mice

1 reference

12 December 2020

Bcl-xL is expressed in neuroblastoma cells and modulates chemotherapy-induced apoptosis

1 reference

12 December 2020

bcl-w, a novel member of the bcl-2 family, promotes cell survival

1 reference

12 December 2020

Bcl-XL protects cancer cells from p53-mediated apoptosis

1 reference

12 December 2020

Stress-resistance conferred by high level of bcl-2 alpha protein in human B lymphoblastoid cell.

1 reference

12 December 2020

Antisense-mediated inhibition of BCL2 protooncogene expression and leukemic cell growth and survival: comparisons of phosphodiester and phosphorothioate oligodeoxynucleotides

1 reference

12 December 2020

E mu-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells.

1 reference

12 December 2020

Pre-B-cell leukemia with a t(8; 14) and a t(14; 18) translocation is preceded by follicular lymphoma

1 reference

12 December 2020

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis

1 reference

12 December 2020

Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins

1 reference

12 December 2020

Hematopoietic malignancies demonstrate loss-of-function mutations of BAX

1 reference

12 December 2020

G3139 (oblimersen) may inhibit prostate cancer cell growth in a partially bis-CpG-dependent non-antisense manner

1 reference

12 December 2020

Bcl-xL overexpression in human hepatocellular carcinoma

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC.2015.17

1 reference

Dimensions Publication ID

5 September 2017

1032122804

0 references

1 reference