(Q38728616)

5 September 2017

TGFβ promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1. (English)

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5 September 2017

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P-H Huang

1

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5 September 2017

P-J Lu

2

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5 September 2017

L-Y Ding

3

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5 September 2017

P-C Chu

4

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5 September 2017

W-Y Hsu

5

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5 September 2017

C-S Chen

6

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5 September 2017

C-C Tsao

7

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5 September 2017

B-H Chen

8

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5 September 2017

C-T Lee

9

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5 September 2017

Y-S Shan

10

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5 September 2017

C-S Chen

11

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5 September 2017

language of work or name

English

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publication date

28 November 2016

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5 September 2017

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5 September 2017

36

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5 September 2017

16

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5 September 2017

2202-2214

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https://scigraph.springernature.com/pub.10.1038/onc.2016.378

5 September 2017

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cites work

Transforming growth factor-β in the gastrointestinal and hepatic tumor microenvironment.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Cofilin drives cell-invasive and metastatic responses to TGF-β in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Context-Specific Effects of TGF-β/SMAD3 in Cancer Are Modulated by the Epigenome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

TGF-β and αvβ6 integrin act in a common pathway to suppress pancreatic cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Reduced PTEN expression in the pancreas overexpressing transforming growth factor-beta 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Pancreatic cancer-associated retinoblastoma 1 dysfunction enables TGF-β to promote proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Inhibition of transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Neutralizing murine TGFβR2 promotes a differentiated tumor cell phenotype and inhibits pancreatic cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Mutations of c-Cbl in myeloid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Vav1 promotes lung cancer growth by instigating tumor-microenvironment cross-talk via growth factor secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

High nuclear level of Vav1 is a positive prognostic factor in early invasive breast tumors: a role in modulating genes related to the efficiency of metastatic process

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Cross-species epigenetics identifies a critical role for VAV1 in SHH subgroup medulloblastoma maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Expression of VAV1 in the tumour microenvironment of glioblastoma multiforme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Integrated molecular analysis of adult T cell leukemia/lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Vav promotes differentiation of human tumoral myeloid precursors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Vav1 and PU.1 are recruited to the CD11b promoter in APL-derived promyelocytes: role of Vav1 in modulating PU.1-containing complexes during ATRA-induced differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Mutation of Vav1 adaptor region reveals a new oncogenic activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Dynamin 2 potentiates invasive migration of pancreatic tumor cells through stabilization of the Rac1 GEF Vav1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

The Ezh2 methyltransferase complex: actin up in the cytosol

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Polycomb group protein ezh2 controls actin polymerization and cell signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Gene body methylation can alter gene expression and is a therapeutic target in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Functions of DNA methylation: islands, start sites, gene bodies and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Can genome engineering be used to target cancer-associated enhancers?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Coexpression of CD44-positive/CD133-positive cancer stem cells and CD204-positive tumor-associated macrophages is a predictor of survival in pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Genomic analyses identify molecular subtypes of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

TGF-β-dependent active demethylation and expression of the p15ink4b tumor suppressor are impaired by the ZNF217/CoREST complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Mechanism and function of Vav1 localisation in TCR signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Vav1 is a component of transcriptionally active complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Characterization of VIK-1: a new Vav-interacting Kruppel-like protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Function of the nucleotide exchange activity of vav1 in T cell development and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Targeting Pancreatic Cancer Metastasis by Inhibition of Vav1, a Driver of Tumor Cell Invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

IDO inhibits T-cell function through suppressing Vav1 expression and activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Epithelial-mesenchymal plasticity in carcinoma metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Histone deacetylase inhibitors stimulate histone H3 lysine 4 methylation in part via transcriptional repression of histone H3 lysine 4 demethylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

OSU-A9, an indole-3-carbinol derivative, induces cytotoxicity in acute myeloid leukemia through reactive oxygen species-mediated apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Genomic Deletion of PTEN Is Associated with Tumor Progression and Early PSA Recurrence in ERG Fusion-Positive and Fusion-Negative Prostate Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.378

Clinical significance and prognostic value of Vav1 expression in Non-small cell lung cancer.

21 January 2018

1 reference

12 December 2020

vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells

1 reference

12 December 2020

Vav1: A Dr. Jekyll and Mr. Hyde protein--good for the hematopoietic system, bad for cancer

1 reference

12 December 2020

Vitamin E facilitates the inactivation of the kinase Akt by the phosphatase PHLPP1.

1 reference

12 December 2020

Identifiers

DOI

10.1038/ONC.2016.378

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Dimensions Publication ID

5 September 2017

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