(Q33492741)

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Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity

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Europe PubMed Central

PubMed publication ID

27 July 2017

Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

actin cytoskeleton

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Daniel D. Billadeau

8

object named as

Daniel D Billadeau

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Europe PubMed Central

PubMed publication ID

27 July 2017

author name string

Ana V Miletic

1

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Daniel B Graham

2

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Kumiko Sakata-Sogawa

3

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Michio Hiroshima

4

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Michael J Hamann

5

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Saso Cemerski

6

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Tracie Kloeppel

7

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Osami Kanagawa

9

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Makio Tokunaga

10

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

Wojciech Swat

11

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Europe PubMed Central

PubMed publication ID

27 July 2017

language of work or name

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publication date

12 August 2009

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Europe PubMed Central

PubMed publication ID

27 July 2017

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

e6599

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

copyright license

Creative Commons Attribution 4.0 International

12 August 2009

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April 2022 Public Data File from Crossref

copyright status

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describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2719804/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

T cell activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Tec kinases, actin, and cell adhesion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

T-cell-receptor-dependent actin regulatory mechanisms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Regulation of T-cell activation by the cytoskeleton

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Vav proteins control MyD88-dependent oxidative burst

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Persistence of cooperatively stabilized signaling clusters drives T-cell activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Induction of lamellipodia by Kalirin does not require its guanine nucleotide exchange factor activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Vav-family proteins in T-cell signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Impaired IL-4 and c-Maf expression and enhanced Th1-cell development in Vav1-deficient mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

CD28-mediated co-stimulation: a quantitative support for TCR signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Vav1/2/3-null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

DOCK2 is essential for antigen-induced translocation of TCR and lipid rafts, but not PKC-theta and LFA-1, in T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

All roads lead to actin: the intimate relationship between TCR signaling and the cytoskeleton

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Regulation of microtubule-organizing center orientation and actomyosin cytoskeleton rearrangement during immune interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Structural determinants for the biological activity of Vav proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

VAV proteins as signal integrators for multi-subunit immune-recognition receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Signaling to the Rho GTPases: networking with the DH domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Dbl family guanine nucleotide exchange factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Vav-Rac1-mediated activation of the c-Jun N-terminal kinase/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoter

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Tyrosine-phosphorylated Vav1 as a point of integration for T-cell receptor- and CD28-mediated activation of JNK, p38, and interleukin-2 transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Signal transduction by the TCR for antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Identification of the stef gene that encodes a novel guanine nucleotide exchange factor specific for Rac1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

A novel regulator of p21-activated kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Identification and characterization of small GTPase-associated kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Purification of recombinant Rho/Rac/G25K from Escherichia coli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2719804

21 June 2018

Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0006599

21 January 2018

Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0006599

21 January 2018

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0006599

21 January 2018

SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0006599

21 January 2018

Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0006599

21 January 2018

A guanine nucleotide exchange factor-independent function of Vav1 in transcriptional activation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0006599

21 January 2018

Acidic region tyrosines provide access points for allosteric activation of the autoinhibited Vav1 Dbl homology domain

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0006599

21 January 2018

Lineage-specific requirement for the PH domain of Vav1 in the activation of CD4+ but not CD8+ T cells.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0006599

21 January 2018

Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0006599

21 January 2018

ERM proteins regulate cytoskeleton relaxation promoting T cell–APC conjugation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19672294

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single molecule imaging of fluorophores and enzymatic reactions achieved by objective-type total internal reflection fluorescence microscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19672294

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vav proteins in neutrophils are required for FcgammaR-mediated signaling to Rac GTPases and nicotinamide adenine dinucleotide phosphate oxidase component p40(phox)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19672294

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TCR antagonist peptides induce formation of APC-T cell conjugates and activate a Rac signaling pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19672294

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific subdomains of Vav differentially affect T cell and NK cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19672294

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19672294

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse

1 reference

https://pubmed.ncbi.nlm.nih.gov/19672294

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19672294

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse

1 reference

https://pubmed.ncbi.nlm.nih.gov/19672294

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0006599

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

2009PLoSO...4.6599M

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 July 2017

ResearchGate publication ID

0 references

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