(Q38730627)

5 September 2017

Why Does the Intestine Lack Basolateral Efflux Transporters for Cationic Compounds? A Provocative Hypothesis (English)

1 reference

5 September 2017

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26869413%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

author name string

William R Proctor

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26869413%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Xin Ming

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26869413%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

David Bourdet

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26869413%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Tianxiang Kevin Han

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26869413%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Dhiren R Thakker

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26869413%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

language of work or name

English

0 references

publication date

1 February 2016

1 reference

Journal of Pharmaceutical Sciences

5 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26869413%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

volume

105

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26869413%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26869413%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

page(s)

484-496

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26869413%20AND%20SRC:MED&resulttype=core&format=json

Occludin: one protein, many forms

12 June 2020

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The Molecular Basis for Hepatobiliary Transport of Organic Cations and Organic Anions

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Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicity

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Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta

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Purification and functional reconstitution of the rat organic cation transporter OCT1.

7 January 2021

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7 January 2021

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Saturable absorptive transport of the hydrophilic organic cation ranitidine in Caco-2 cells: role of pH-dependent organic cation uptake system and P-glycoprotein.

7 January 2021

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Mechanisms underlying saturable intestinal absorption of metformin

7 January 2021

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Regional distribution of solute carrier mRNA expression along the human intestinal tract

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Discovery of the ergothioneine transporter

7 January 2021

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Decreased proliferation and erythroid differentiation of K562 cells by siRNA-induced depression of OCTN1 (SLC22A4) transporter gene.

7 January 2021

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Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin

7 January 2021

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Functional expression of carnitine/organic cation transporter OCTN1/SLC22A4 in mouse small intestine and liver

7 January 2021

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Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2

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Functional and pharmacological characterization of human Na(+)-carnitine cotransporter hOCTN2.

7 January 2021

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beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter

7 January 2021

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Uptake of cardiovascular drugs into the human heart: expression, regulation, and function of the carnitine transporter OCTN2 (SLC22A5).

7 January 2021

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Expression and localization of organic cation/carnitine transporter OCTN2 in Caco-2 cells

7 January 2021

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Molecular evolution of the equilibrative nucleoside transporter family: identification of novel family members in prokaryotes and eukaryotes

7 January 2021

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Metformin transport by a newly cloned proton-stimulated organic cation transporter (plasma membrane monoamine transporter) expressed in human intestine

7 January 2021

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Interaction of organic cations with a newly identified plasma membrane monoamine transporter

7 January 2021

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Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties

7 January 2021

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Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver

7 January 2021

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Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells

7 January 2021

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Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants

7 January 2021

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Identification of influx transporter for the quinolone antibacterial agent levofloxacin

7 January 2021

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Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine

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Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides

7 January 2021

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Intestinal drug transporter expression and the impact of grapefruit juice in humans

7 January 2021

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Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family

7 January 2021

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Predominant contribution of organic anion transporting polypeptide OATP-B (OATP2B1) to apical uptake of estrone-3-sulfate by human intestinal Caco-2 cells.

7 January 2021

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7 January 2021

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Functional Characterization of pH-Sensitive Organic Anion Transporting Polypeptide OATP-B in Human

7 January 2021

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Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B.

7 January 2021

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Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis

7 January 2021

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Targeting multidrug resistance in cancer

7 January 2021

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Membrane transporters in drug development

7 January 2021

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Intestinal drug transporters: an overview

7 January 2021

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Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.

7 January 2021

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cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats

7 January 2021

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Integration of hepatic drug transporters and phase II metabolizing enzymes: mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites

7 January 2021

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Multidrug resistance protein 2 is an important determinant of paclitaxel pharmacokinetics

7 January 2021

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Multidrug resistance-associated proteins 3, 4, and 5.

7 January 2021

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Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception

7 January 2021

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Impact of basolateral multidrug resistance-associated protein (Mrp) 3 and Mrp4 on the hepatobiliary disposition of fexofenadine in perfused mouse livers.

7 January 2021

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Involvement of multiple efflux transporters in hepatic disposition of fexofenadine

7 January 2021

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Mapping of multidrug resistance gene 1 and multidrug resistance-associated protein isoform 1 to 5 mRNA expression along the human intestinal tract

7 January 2021

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The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis

7 January 2021

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Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides.

7 January 2021

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7 January 2021

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MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs

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Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4).

7 January 2021

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Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites.

7 January 2021

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Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane

7 January 2021

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Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damage.

7 January 2021

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Drug exsorption from blood into the gastrointestinal tract

7 January 2021

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Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics

7 January 2021

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P-glycoprotein plays a major role in the efflux of fexofenadine in the small intestine and blood-brain barrier, but only a limited role in its biliary excretion

7 January 2021

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Clinical Potential of the Acyclic Nucleoside Phosphonates Cidofovir, Adefovir, and Tenofovir in Treatment of DNA Virus and Retrovirus Infections

7 January 2021

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Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients

7 January 2021

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7 January 2021

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Anti-human immunodeficiency virus (HIV) activity, safety, and pharmacokinetics of adefovir dipivoxil (9-[2-(bis-pivaloyloxymethyl)-phosphonylmethoxyethyl]adenine) in HIV-infected patients

7 January 2021

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Pharmacokinetic and pharmacodynamic properties of histamine H2-receptor antagonists. Relationship between intrinsic potency and effective plasma concentrations

7 January 2021

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Cardiac and gastric effects of histamine H2 receptor antagonists: no evidence for a correlation between lipophilicity and receptor affinity

7 January 2021

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Secretory transport of ranitidine and famotidine across Caco-2 cell monolayers

7 January 2021

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Metformin kinetics in healthy subjects and in patients with diabetes mellitus

7 January 2021

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Pharmacokinetics of metformin after intravenous and oral administration to man

7 January 2021

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Food intake and dosage level, but not tablet vs solution dosage form, affect the absorption of metformin HCl in man.

7 January 2021

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Pharmacokinetics and pharmacodynamics of metformin in healthy subjects and patients with noninsulin-dependent diabetes mellitus

7 January 2021

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Intestinal permeability of metformin using single-pass intestinal perfusion in rats

7 January 2021

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Metformin in the digestive tract

7 January 2021

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Metformin and the intestine

7 January 2021

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Accumulation of metformin by tissues of the normal and diabetic mouse

7 January 2021

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Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1.

7 January 2021

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Metformin transport by renal basolateral organic cation transporter hOCT2.

7 January 2021

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Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver

7 January 2021

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Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

7 January 2021

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A comparison of uptake of metformin and phenformin mediated by hOCT1 in human hepatocytes

7 January 2021

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Four cation-selective transporters contribute to apical uptake and accumulation of metformin in Caco-2 cell monolayers

7 January 2021

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Genetic variants of organic cation transporter 2 (OCT2) significantly reduce metformin uptake in oocytes

7 January 2021

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Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin.

7 January 2021

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Involvement of carnitine/organic cation transporter OCTN1/SLC22A4 in gastrointestinal absorption of metformin.

7 January 2021

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Comparative gene expression profiles of intestinal transporters in mice, rats and humans.

7 January 2021

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Novel localization of OCTN1, an organic cation/carnitine transporter, to mammalian mitochondria

7 January 2021

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Epitope shared by functional variant of organic cation/carnitine transporter, OCTN1, Campylobacter jejuni and Mycobacterium paratuberculosis may underlie susceptibility to Crohn's disease at 5q31.

7 January 2021

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Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters

7 January 2021

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Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2.

7 January 2021

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A human transporter protein that mediates the final excretion step for toxic organic cations

7 January 2021

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Identification and characterization of a novel monoamine transporter in the human brain

7 January 2021

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Prediction and validation of enzyme and transporter off-targets for metformin.

7 January 2021

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Mechanisms for membrane transport of metformin in human intestinal epithelial Caco-2 cells

7 January 2021

1 reference

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Intestinal absorptive transport of the hydrophilic cation ranitidine: a kinetic modeling approach to elucidate the role of uptake and efflux transporters and paracellular vs. transcellular transport in Caco-2 cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.XPHS.2015.11.040

Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells

7 January 2021

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Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture

7 January 2021

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Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes.

7 January 2021

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The density of small tight junction pores varies among cell types and is increased by expression of claudin-2.

7 January 2021

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Regional levels of drug transporters along the human intestinal tract: co-expression of ABC and SLC transporters and comparison with Caco-2 cells

7 January 2021

1 reference

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Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

7 January 2021

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Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2.

7 January 2021

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