(Q38779774)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28001443%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

title

Restoring BMPRII functions in pulmonary arterial hypertension: opportunities, challenges and limitations (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28001443%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

main subject

arterial hypertension

1 reference

based on heuristic

inferred from title

author

Christophe Guignabert

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28001443%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

Sabine Bailly

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28001443%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

Marc Humbert

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28001443%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

Christophe Guignabert

1

object named as

Christophe Guignabert

1 reference

6 September 2017

Sabine Bailly

2

1 reference

6 September 2017

language of work or name

English

0 references

publication date

28 December 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28001443%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Therapeutic Targets

1 April 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28001443%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

volume

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28001443%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28001443%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

page(s)

181-190

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28001443%20AND%20SRC:MED&resulttype=core&format=json

Pulmonary arterial hypertension in France: results from a national registry

1 April 2020

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New molecular targets of pulmonary vascular remodeling in pulmonary arterial hypertension: importance of endothelial communication

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Pathogenesis of pulmonary arterial hypertension: lessons from cancer

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Immune dysregulation and endothelial dysfunction in pulmonary arterial hypertension: a complex interplay

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Molecular pathogenesis of pulmonary arterial hypertension

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Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension

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Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene

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BMPR2 mutations and survival in pulmonary arterial hypertension: an individual participant data meta-analysis

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Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension

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Pathogenesis of pulmonary arterial hypertension: the need for multiple hits.

21 January 2018

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Recent advances in BMP receptor signaling

21 January 2018

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Spatial regulation of BMP activity

21 January 2018

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Extracellular microfibrils: contextual platforms for TGFbeta and BMP signaling

21 January 2018

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Signaling of transforming growth factor-beta family members through Smad proteins

21 January 2018

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BMP signaling in vascular biology and dysfunction

21 January 2018

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Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis

21 January 2018

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Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription.

21 January 2018

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Non-Smad TGF-beta signals

21 January 2018

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TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation

21 January 2018

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

21 January 2018

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MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension

21 January 2018

1 reference

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miR-106b-5p and miR-17-5p suppress osteogenic differentiation by targeting Smad5 and inhibit bone formation

21 January 2018

1 reference

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Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

21 January 2018

1 reference

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Structural insights into BMP receptors: Specificity, activation and inhibition

21 January 2018

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Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia.

21 January 2018

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Smooth muscle protein 22alpha-mediated patchy deletion of Bmpr1a impairs cardiac contractility but protects against pulmonary vascular remodeling

21 January 2018

1 reference

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SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis

21 January 2018

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Hypoxia induces alteration of bone morphogenetic protein receptor signaling in pulmonary artery endothelial cell

21 January 2018

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Smad signaling in the rat model of monocrotaline pulmonary hypertension

21 January 2018

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Id proteins are critical downstream effectors of BMP signaling in human pulmonary arterial smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Arterial endothelium-specific activin receptor-like kinase 1 expression suggests its role in arterialization and vascular remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Functional characterization of bone morphogenetic protein binding sites and Smad1/5 activation in human vascular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor

21 January 2018

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Regulation of bone morphogenetic protein signalling in human pulmonary vascular development

21 January 2018

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Dysfunctional Smad Signaling Contributes to Abnormal Smooth Muscle Cell Proliferation in Familial Pulmonary Arterial Hypertension

21 January 2018

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Signaling molecules in nonfamilial pulmonary hypertension

21 January 2018

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Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells

21 January 2018

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Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension.

21 January 2018

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Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension.

21 January 2018

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Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival

21 January 2018

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Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function

21 January 2018

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Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo.

21 January 2018

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Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension

21 January 2018

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Mutations in bone morphogenetic protein type II receptor cause dysregulation of Id gene expression in pulmonary artery smooth muscle cells: implications for familial pulmonary arterial hypertension

21 January 2018

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Macrophage bone morphogenic protein receptor 2 depletion in idiopathic pulmonary fibrosis and Group III pulmonary hypertension

21 January 2018

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Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein-induced activation of endothelial cells

21 January 2018

1 reference

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Interaction between alk1 and blood flow in the development of arteriovenous malformations

21 January 2018

1 reference

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Hemodynamic forces, vascular oxidative stress, and regulation of BMP-2/4 expression

21 January 2018

1 reference

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Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

BMP receptor-integrin interaction mediates responses of vascular endothelial Smad1/5 and proliferation to disturbed flow

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Integrins in mechanotransduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

The role of BMPs in endothelial cell function and dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Bone morphogenetic protein endothelial cell precursor-derived regulator regulates retinal angiogenesis in vivo in a mouse model of oxygen-induced retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Inhibition of apelin expression by BMP signaling in endothelial cells.

21 January 2018

1 reference

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Endothelial cells are activated during hypoxia via endoglin/ALK-1/SMAD1/5 signaling in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Genetics and genomics of pulmonary arterial hypertension

21 January 2018

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https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Longitudinal analysis casts doubt on the presence of genetic anticipation in heritable pulmonary arterial hypertension.

21 January 2018

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Transforming growth factor-beta receptor mutations and pulmonary arterial hypertension in childhood

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Identification of multiple ACVRL1 mutations in patients with pulmonary arterial hypertension by targeted exome capture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Clinical outcomes of pulmonary arterial hypertension in patients carrying an ACVRL1 (ALK1) mutation

21 January 2018

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Endoglin germline mutation in a patient with hereditary haemorrhagic telangiectasia and dexfenfluramine associated pulmonary arterial hypertension

21 January 2018

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Mutational and clinical analysis of the ENG gene in patients with pulmonary arterial hypertension

21 January 2018

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A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension

21 January 2018

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Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension

21 January 2018

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A novel channelopathy in pulmonary arterial hypertension

21 January 2018

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Clinical outcomes of pulmonary arterial hypertension in carriers of BMPR2 mutation.

21 January 2018

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Genetic counselling in a national referral centre for pulmonary hypertension.

21 January 2018

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Diffusion capacity and BMPR2 mutations in pulmonary arterial hypertension

21 January 2018

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Modern age pathology of pulmonary arterial hypertension

21 January 2018

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Angiomatoid fibrous histiocytoma of the pulmonary artery: a multidisciplinary discussion.

21 January 2018

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Bone Morphogenetic Protein Receptor Type 2 Mutation in Pulmonary Arterial Hypertension: A View on the Right Ventricle.

21 January 2018

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BMPR2 mutation status influences bronchial vascular changes in pulmonary arterial hypertension.

21 January 2018

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Bone morphogenetic protein signalling in heritable versus idiopathic pulmonary hypertension

21 January 2018

1 reference

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Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Increased Mutagen Sensitivity and DNA Damage in Pulmonary Arterial Hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

BMPR2 preserves mitochondrial function and DNA during reoxygenation to promote endothelial cell survival and reverse pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Estrogen Metabolite 16α-Hydroxyestrone Exacerbates Bone Morphogenetic Protein Receptor Type II-Associated Pulmonary Arterial Hypertension Through MicroRNA-29-Mediated Modulation of Cellular Metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Hyperoxia synergizes with mutant bone morphogenic protein receptor 2 to cause metabolic stress, oxidant injury, and pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Evidence for right ventricular lipotoxicity in heritable pulmonary arterial hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Mechanisms of Lipid Accumulation in the Bone Morphogenetic Protein Receptor Type 2 Mutant Right Ventricle

21 January 2018

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Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions

21 January 2018

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https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension

21 January 2018

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https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Physiologic and molecular consequences of endothelial Bmpr2 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

S100A4 and bone morphogenetic protein-2 codependently induce vascular smooth muscle cell migration via phospho-extracellular signal-regulated kinase and chloride intracellular channel 4

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

A critical role for p130Cas in the progression of pulmonary hypertension in humans and rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Rho-kinase inhibition alleviates pulmonary hypertension in transgenic mice expressing a dominant-negative type II bone morphogenetic protein receptor gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Bone Morphogenetic Protein (BMP) signaling in development and human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Dosage-dependent requirement of BMP type II receptor for maintenance of vascular integrity.

21 January 2018

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https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Endothelial-to-mesenchymal transition in pulmonary hypertension.

21 January 2018

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https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Attenuation of leukocyte recruitment via CXCR1/2 inhibition stops the progression of PAH in mice with genetic ablation of endothelial BMPR-II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

SMAD1 deficiency in either endothelial or smooth muscle cells can predispose mice to pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

BMPR2 gene delivery reduces mutation-related PAH and counteracts TGF-β-mediated pulmonary cell signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

The promise of recombinant BMP ligands and other approaches targeting BMPR-II in the treatment of pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Targeting BMP signalling in cardiovascular disease and anaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

The transforming growth factor-β-bone morphogenetic protein type signalling pathway in pulmonary vascular homeostasis and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Rescuing the BMPR2 signaling axis in pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

TGF-beta and BMPR-II pharmacology--implications for pulmonary vascular diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Targeted gene delivery of BMPR2 attenuates pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Low-Dose FK506 (Tacrolimus) in End-Stage Pulmonary Arterial Hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

AntagomiR directed against miR-20a restores functional BMPR2 signalling and prevents vascular remodelling in hypoxia-induced pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Correction of nonsense BMPR2 and SMAD9 mutations by ataluren in pulmonary arterial hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Truncating and missense BMPR2 mutations differentially affect the severity of heritable pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Absence of influence of gender and BMPR2 mutation type on clinical phenotypes of pulmonary arterial hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Effectiveness of PTC124 treatment of cystic fibrosis caused by nonsense mutations: a prospective phase II trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Overexpression of the serine elastase inhibitor elafin protects transgenic mice from hypoxic pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Failure of bone morphogenetic protein receptor trafficking in pulmonary arterial hypertension: potential for rescue

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

BMPR2 expression is suppressed by signaling through the estrogen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Regulatory T cells limit vascular endothelial injury and prevent pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Role of BMPR2 alternative splicing in heritable pulmonary arterial hypertension penetrance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

Osteogenic molecules for clinical applications: improving the BMP-collagen system

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F14728222.2017.1275567

10.1080/14728222.2017.1275567

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28001443%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

1 reference