(Q38786667)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27009395%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

title

The importance of p53 pathway genetics in inherited and somatic cancer genomes (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27009395%20AND%20SRC:MED&resulttype=core&format=json

Benjamin Schuster-Böckler

30 March 2020

author

17

1 reference

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30 March 2020

Giovanni Stracquadanio

1

1 reference

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30 March 2020

Xuting Wang

2

1 reference

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30 March 2020

Jorge Zeron-Medina

7

1 reference

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30 March 2020

Francesc Castro-giner

8

1 reference

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30 March 2020

Colin R. Goding

10

1 reference

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30 March 2020

William G Fairbrother

12

1 reference

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30 March 2020

Laurent F Thomas

13

1 reference

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30 March 2020

Pål Sætrom

14

1 reference

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30 March 2020

9

Ian P Tomlinson

1 reference

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30 March 2020

Douglas A Bell

18

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author name string

Marsha D Wallace

3

1 reference

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30 March 2020

Anna M Grawenda

4

1 reference

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30 March 2020

Ping Zhang

5

1 reference

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30 March 2020

Juliet Hewitt

6

1 reference

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30 March 2020

Kamil J Cygan

11

1 reference

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30 March 2020

Federica Gemignani

15

1 reference

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30 March 2020

Stefano Landi

16

1 reference

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30 March 2020

Gareth L Bond

19

1 reference

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30 March 2020

language of work or name

English

0 references

publication date

1 April 2016

1 reference

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30 March 2020

published in

Nature Reviews Cancer

1 reference

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30 March 2020

volume

16

1 reference

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30 March 2020

page(s)

251-265

1 reference

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30 March 2020

issue

4

1 reference

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https://scigraph.springernature.com/pub.10.1038/nrc.2016.15

30 March 2020

exact match

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Caspase-8 gene is frequently inactivated by the frameshift somatic mutation 1225_1226delTG in hepatocellular carcinomas.

21 January 2018

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Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survival

21 January 2018

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Genetic landscape of esophageal squamous cell carcinoma

21 January 2018

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

21 January 2018

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Value of integrated positron emission tomography revised using a phantom study to evaluate malignancy grade of lung adenocarcinoma: a multicenter study

21 January 2018

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Concurrent disruption of p16INK4a and the ARF-p53 pathway predicts poor prognosis in aggressive non-Hodgkin's lymphoma.

21 January 2018

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Autoimmune lymphoproliferative syndrome with somatic Fas mutations

21 January 2018

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21 January 2018

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Somatic mutations in the death domain of the Fas (Apo-1/CD95) gene in gastric cancer.

21 January 2018

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MDM4 is a key therapeutic target in cutaneous melanoma

21 January 2018

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COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

21 January 2018

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A germline variant in the TP53 polyadenylation signal confers cancer susceptibility

21 January 2018

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Further confirmation of germline glioma risk variant rs78378222 in TP53 and its implication in tumor tissues via integrative analysis of TCGA data

21 January 2018

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The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma

21 January 2018

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Cyclin D1 splice variants: polymorphism, risk, and isoform-specific regulation in prostate cancer

21 January 2018

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Identification of ASF/SF2 as a critical, allele-specific effector of the cyclin D1b oncogene

21 January 2018

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Cyclin D1: polymorphism, aberrant splicing and cancer risk

21 January 2018

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21 January 2018

Modes of p53 regulation

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Deconstructing p53 transcriptional networks in tumor suppression

21 January 2018

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The role of p53 in ribosomopathies

21 January 2018

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Animal models of Diamond Blackfan anemia

21 January 2018

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Guilty as CHARGED: p53's expanding role in disease

21 January 2018

1 reference

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Enhanced and accelerated lymphoproliferation in Fas-null mice

21 January 2018

1 reference

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Atm-deficient mice: a paradigm of ataxia telangiectasia

21 January 2018

1 reference

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Unravelling mechanisms of p53-mediated tumour suppression

21 January 2018

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CD95 promotes tumour growth

21 January 2018

1 reference

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Cyclin E ablation in the mouse

21 January 2018

1 reference

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Caspase-8 is essential for maintaining chromosomal stability and suppressing B-cell lymphomagenesis

21 January 2018

1 reference

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The combined status of ATM and p53 link tumor development with therapeutic response

21 January 2018

1 reference

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

1 reference

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Atm is a negative regulator of intestinal neoplasia

21 January 2018

1 reference

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Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.15

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.15

Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.15

A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.15

Activation and activities of the p53 tumour suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.15

The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways

21 January 2018

1 reference

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The p53 pathway: positive and negative feedback loops

21 January 2018

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p53: 25 years after its discovery

21 January 2018

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The P53 pathway: what questions remain to be explored?

21 January 2018

1 reference

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Divorcing ARF and p53: an unsettled case

21 January 2018

1 reference

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The role of p53-target genes in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.15

Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.15

Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.15

Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.15

Locus-specific mutation databases: pitfalls and good practice based on the p53 experience

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.15

p53 tumor suppressor protein regulates the levels of huntingtin gene expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.15

Which cyclin E prevails as prognostic marker for breast cancer? Results from a retrospective study involving 635 lymph node-negative breast cancer patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.15

Inappropriate p53 activation during development induces features of CHARGE syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.15

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.15

Kinase-independent function of cyclin E

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.15

Overexpression of cyclin D2 is associated with increased in vivo invasiveness of human squamous carcinoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.15

20 years studying p53 functions in genetically engineered mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.15

A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

31 March 2020

1 reference

12 December 2020

ΔNp63 expression is associated with poor survival in ovarian cancer

1 reference

12 December 2020

Mammary tumorigenesis following transgenic expression of a dominant negative CHK2 mutant

1 reference

12 December 2020

Tumor spectrum in ARF-deficient mice.

1 reference

12 December 2020

p53 has a direct apoptogenic role at the mitochondria

1 reference

12 December 2020

Gene amplification CCNE1 is related to poor survival and potential therapeutic target in ovarian cancer

1 reference

12 December 2020

Mice with the CHEK2*1100delC SNP are predisposed to cancer with a strong gender bias

1 reference

12 December 2020

14-3-3 proteins in cell cycle regulation

1 reference

12 December 2020

Regulation of the G2/M transition by p53.

1 reference

12 December 2020

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

1 reference

12 December 2020

Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis

1 reference

12 December 2020

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

1 reference

12 December 2020

Hepatocellular carcinoma results from chronic cyclin D1 overexpression in transgenic mice.

1 reference

12 December 2020

BCL2 mutations in diffuse large B-cell lymphoma

1 reference

12 December 2020

Alternate splicing produces a novel cyclin D1 transcript.

1 reference

12 December 2020

p63 and p73, the ancestors of p53.

1 reference

12 December 2020

Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

1 reference

12 December 2020

p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor

1 reference

12 December 2020

Atm knock-in mice harboring an in-frame deletion corresponding to the human ATM 7636del9 common mutation exhibit a variant phenotype

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC.2016.15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27009395%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

30 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27009395%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27009395%20AND%20SRC:MED&resulttype=core&format=json