(Q38800184)

6 September 2017

MST1: a promising therapeutic target to restore functional beta cell mass in diabetes (English)

1 reference

6 September 2017

Kathrin Maedler

2

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author name string

Amin Ardestani

series ordinal

1

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6 September 2017

6 April 2016

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6 September 2017

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6 September 2017

59

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6 September 2017

1843-1849

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6 September 2017

9

1 reference

https://scigraph.springernature.com/pub.10.1007/s00125-016-3892-9

6 September 2017

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cites work

Relationship between beta-cell mass and fasting blood glucose concentration in humans

1 reference

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β cell death and dysfunction during type 1 diabetes development in at-risk individuals

21 January 2018

1 reference

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

21 January 2018

1 reference

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beta-Cell death during progression to diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

21 January 2018

1 reference

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The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version

21 January 2018

1 reference

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The Hippo pathway and human cancer.

21 January 2018

1 reference

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The Hippo transducer YAP1 transforms activated satellite cells and is a potent effector of embryonal rhabdomyosarcoma formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model

21 January 2018

1 reference

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The Hippo superhighway: signaling crossroads converging on the Hippo/Yap pathway in stem cells and development

21 January 2018

1 reference

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Impaired Hippo signaling promotes Rho1-JNK-dependent growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

Protein kinases of the Hippo pathway: regulation and substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

The DeMSTification of mammalian Ste20 kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

Caspases and kinases in a death grip

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

21 January 2018

1 reference

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Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

21 January 2018

1 reference

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Exploiting the PI3K/AKT pathway for cancer drug discovery

21 January 2018

1 reference

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Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

Increased islet apoptosis in Pdx1+/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic β cell death and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

Pdx1 restores beta cell function in Irs2 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

IPF1/PDX1 deficiency and beta-cell dysfunction in Psammomys obesus, an animal With type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

Phosphorylation-dependent nucleocytoplasmic shuttling of pancreatic duodenal homeobox-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

Phosphorylation marks IPF1/PDX1 protein for degradation by glycogen synthase kinase 3-dependent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

Regulation of the pancreatic duodenal homeobox-1 protein by DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

Sumoylation of Pdx1 is associated with its nuclear localization and insulin gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

The transcription factor PDX-1 is post-translationally modified by O-linked N-acetylglucosamine and this modification is correlated with its DNA binding activity and insulin secretion in min6 beta-cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

Pancreatic and duodenal homeobox 1 (PDX1) phosphorylation at serine-269 is HIPK2-dependent and affects PDX1 subnuclear localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

Glucose-dependent translocation of insulin promoter factor-1 (IPF-1) between the nuclear periphery and the nucleoplasm of single MIN6 beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-016-3892-9

Early-onset type-II diabetes mellitus (MODY4) linked to IPF1

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27053234

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1007/S00125-016-3892-9

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/rwp355fhk5amfeczrf72jtcd6m

30 July 2022

mapped directly with Wikidata item

Dimensions Publication ID

1027815661

0 references

Fatcat ID

release_rwp355fhk5amfeczrf72jtcd6m

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/rwp355fhk5amfeczrf72jtcd6m

30 July 2022

mapped directly with Wikidata item

1 reference

https://api.fatcat.wiki/v0/release/rwp355fhk5amfeczrf72jtcd6m

30 July 2022