(Q38810897)

6 September 2017

Autoimmune regulator and self-tolerance - molecular and clinical aspects (English)

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6 September 2017

1

Jakub Abramson

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6 September 2017

2

Eystein S Husebye

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6 September 2017

1 May 2016

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6 September 2017

Immunological Reviews

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6 September 2017

271

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6 September 2017

1

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6 September 2017

127-140

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Recent insights in the epidemiology of autoimmune diseases: improved prevalence estimates and understanding of clustering of diseases

6 September 2017

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Genetic basis of autoimmunity

21 January 2018

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Clinical manifestations and management of patients with autoimmune polyendocrine syndrome type I.

21 January 2018

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Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines

21 January 2018

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Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I

21 January 2018

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Dominant Mutations in the Autoimmune Regulator AIRE Are Associated with Common Organ-Specific Autoimmune Diseases

21 January 2018

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An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

21 January 2018

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Positional cloning of the APECED gene

21 January 2018

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Projection of an immunological self shadow within the thymus by the aire protein

21 January 2018

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Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia

21 January 2018

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Aire controls gene expression in the thymic epithelium with ordered stochasticity

21 January 2018

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Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

21 January 2018

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Immune tolerance. Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance

21 January 2018

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Transcriptional regulation by AIRE: molecular mechanisms of central tolerance

21 January 2018

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21 January 2018

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AIRE: From promiscuous molecular partnerships to promiscuous gene expression

21 January 2018

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Acquired autoimmune polyglandular syndrome, thymoma, and an AIRE defect

21 January 2018

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Clinical and serologic parallels to APS-I in patients with thymomas and autoantigen transcripts in their tumors

21 January 2018

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Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency

21 January 2018

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The biophysical and biochemical properties of the autoimmune regulator (AIRE) protein

21 January 2018

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AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity.

21 January 2018

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The versatile roles of CARDs in regulating apoptosis, inflammation, and NF-κB signaling.

21 January 2018

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The autoimmune regulator protein has transcriptional transactivating properties and interacts with the common coactivator CREB-binding protein

21 January 2018

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The autoimmune regulator (AIRE) is a DNA-binding protein

21 January 2018

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The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.

21 January 2018

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Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire

21 January 2018

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The SAND domain structure defines a novel DNA-binding fold in transcriptional regulation

21 January 2018

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Crystal structure and nuclear magnetic resonance analyses of the SAND domain from glucocorticoid modulatory element binding protein-1 reveals deoxyribonucleic acid and zinc binding regions

21 January 2018

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Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity.

21 January 2018

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The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression

21 January 2018

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The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

21 January 2018

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Aire's plant homeodomain(PHD)-2 is critical for induction of immunological tolerance

21 January 2018

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Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla.

21 January 2018

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Subcellular location and expression pattern of autoimmune regulator (Aire), the mouse orthologue for human gene defective in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED)

21 January 2018

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Deletional tolerance mediated by extrathymic Aire-expressing cells

21 January 2018

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Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction.

21 January 2018

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Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation

21 January 2018

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Expression of Aire and the early wave of apoptosis in spermatogenesis

21 January 2018

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Transcriptional impact of Aire varies with cell type

21 January 2018

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Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire

21 January 2018

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Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated

21 January 2018

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Single-cell transcriptome analysis reveals coordinated ectopic gene-expression patterns in medullary thymic epithelial cells

21 January 2018

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NF-kappaB2 is required for the establishment of central tolerance through an Aire-dependent pathway

21 January 2018

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Lymphotoxin pathway directs thymic Aire expression

21 January 2018

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A highly conserved NF-κB-responsive enhancer is critical for thymic expression of Aire in mice.

21 January 2018

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Identification of a novel cis-regulatory element essential for immune tolerance

21 January 2018

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Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus

21 January 2018

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AIRE activated tissue specific genes have histone modifications associated with inactive chromatin

21 January 2018

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Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells

21 January 2018

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Getting up to speed with transcription elongation by RNA polymerase II

21 January 2018

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AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells

21 January 2018

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An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription

21 January 2018

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Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cells

21 January 2018

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The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

21 January 2018

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BRD4 assists elongation of both coding and enhancer RNAs by interacting with acetylated histones

21 January 2018

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A Genetically Encoded FRET Probe to Detect Intranucleosomal Histone H3K9 or H3K14 Acetylation Using BRD4, a BET Family Member

21 January 2018

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Aire's partners in the molecular control of immunological tolerance

21 January 2018

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DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity

21 January 2018

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AIRE-PHD fingers are structural hubs to maintain the integrity of chromatin-associated interactome

21 January 2018

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Unmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes

21 January 2018

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Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner

21 January 2018

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Cooperative activation of transcription by autoimmune regulator AIRE and CBP.

21 January 2018

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The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance

21 January 2018

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Sirtuin 1 in immune regulation and autoimmunity

21 January 2018

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Identification of a SIRT1 mutation in a family with type 1 diabetes

21 January 2018

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The cellular mechanism of Aire control of T cell tolerance.

21 January 2018

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Regulatory T cell defect in APECED patients is associated with loss of naive FOXP3(+) precursors and impaired activated population.

21 January 2018

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The susceptibility of Aire(-/-) mice to experimental myasthenia gravis involves alterations in regulatory T cells.

21 January 2018

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Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development

21 January 2018

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Aire-dependent thymic development of tumor-associated regulatory T cells

21 January 2018

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Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus

21 January 2018

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Clinical variation of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) in a series of 68 patients.

21 January 2018

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Prevalence and clinical associations of 10 defined autoantibodies in autoimmune polyendocrine syndrome type I.

21 January 2018

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Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction

21 January 2018

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Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen

21 January 2018

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BPIFB1 is a lung-specific autoantigen associated with interstitial lung disease

21 January 2018

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Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.

21 January 2018

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Mutations in the AIRE gene: effects on subcellular location and transactivation function of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy protein

21 January 2018

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Autoimmune polyendocrine syndrome type 1 in Norway: phenotypic variation, autoantibodies, and novel mutations in the autoimmune regulator gene.

21 January 2018

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A common and recurrent 13-bp deletion in the autoimmune regulator gene in British kindreds with autoimmune polyendocrinopathy type 1

21 January 2018

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A common mutation in Sardinian autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients.

21 January 2018

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Polyglandular autoimmune syndrome type I among Iranian Jews

21 January 2018

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Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

21 January 2018

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Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

21 January 2018

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Modifier loci condition autoimmunity provoked by Aire deficiency

21 January 2018

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Anti-interferon autoantibodies in autoimmune polyendocrinopathy syndrome type 1

21 January 2018

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Aire deficient mice do not develop the same profile of tissue-specific autoantibodies as APECED patients.

21 January 2018

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Transglutaminase 4 as a prostate autoantigen in male subfertility

21 January 2018

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The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice

21 January 2018

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Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells

21 January 2018

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Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival.

21 January 2018

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RAG-dependent primary immunodeficiencies.

21 January 2018

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Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance

21 January 2018

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AIRE deficiency in thymus of 2 patients with Omenn syndrome

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/IMR.12419

1 reference

6 September 2017

1 reference

PubMed ID

27088911