(Q38822996)

6 September 2017

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title

Genomics of Alzheimer Disease: A Review (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6759853&resulttype=core&format=json

12 May 2020

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Doris Lambracht-Washington

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6759853&resulttype=core&format=json

12 May 2020

author name string

Roger N Rosenberg

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6759853&resulttype=core&format=json

12 May 2020

Gang Yu

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6759853&resulttype=core&format=json

12 May 2020

Weiming Xia

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6759853&resulttype=core&format=json

12 May 2020

language of work or name

English

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publication date

2 May 2016

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6 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6759853&resulttype=core&format=json

12 May 2020

volume

73

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6759853&resulttype=core&format=json

12 May 2020

page(s)

867-874

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6759853&resulttype=core&format=json

12 May 2020

issue

7

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6759853&resulttype=core&format=json

Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease

12 May 2020

cites work

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12 December 2020

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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12 December 2020

Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts

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12 December 2020

Novel Leu723Pro amyloid precursor protein mutation increases amyloid beta42(43) peptide levels and induces apoptosis

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12 December 2020

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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12 December 2020

Early-onset Alzheimer disease caused by a new mutation (V717L) in the amyloid precursor protein gene

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12 December 2020

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

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12 December 2020

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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12 December 2020

Conservation of PCDHX in mammals; expression of human X/Y genes predominantly in brain

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12 December 2020

Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease

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12 December 2020

Molecular genetics of chromosome 17 tauopathies.

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12 December 2020

Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy

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12 December 2020

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

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12 December 2020

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

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12 December 2020

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

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12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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12 December 2020

Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease

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12 December 2020

A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton

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12 December 2020

Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization

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12 December 2020

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

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12 December 2020

Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.

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12 December 2020

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

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12 December 2020

Amyloid beta-peptide is produced by cultured cells during normal metabolism

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12 December 2020

Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region

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12 December 2020

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

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12 December 2020

Novel APP mutation V715A associated with presenile Alzheimer's disease in a German family.

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12 December 2020

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

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12 December 2020

Alzheimer disease: mechanistic understanding predicts novel therapies

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12 December 2020

Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease

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12 December 2020

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

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12 December 2020

Deciphering the molecular basis of memory failure in Alzheimer's disease

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12 December 2020

Presenilin-dependent processing and nuclear function of gamma-protocadherins.

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12 December 2020

Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.

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12 December 2020

Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease.

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12 December 2020

Nicastrin functions as a gamma-secretase-substrate receptor

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12 December 2020

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

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12 December 2020

APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

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12 December 2020

The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments

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12 December 2020

Abeta42 gene vaccination reduces brain amyloid plaque burden in transgenic mice.

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12 December 2020

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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12 December 2020

Progress from Alzheimer's tangles to pathological tau points towards more effective therapies now.

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12 December 2020

Alzheimer dementia caused by a novel mutation located in the APP C-terminal intracytosolic fragment.

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12 December 2020

Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system

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12 December 2020

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

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12 December 2020

Abeta42 gene vaccine prevents Abeta42 deposition in brain of double transgenic mice.

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12 December 2020

Clearance of amyloid-beta by circulating lipoprotein receptors

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12 December 2020

18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease.

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12 December 2020

Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

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12 December 2020

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

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12 December 2020

Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP

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12 December 2020

Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease

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12 December 2020

A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease

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12 December 2020

A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

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12 December 2020

Synaptic activity prompts gamma-secretase-mediated cleavage of EphA4 and dendritic spine formation

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12 December 2020

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

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12 December 2020

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

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12 December 2020

DNA beta-amyloid(1-42) trimer immunization for Alzheimer disease in a wild-type mouse model.

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12 December 2020

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

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12 December 2020

Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta

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12 December 2020

Analysis of three plasmid systems for use in DNA A beta 42 immunization as therapy for Alzheimer's disease

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12 December 2020

Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes

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12 December 2020

Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.

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12 December 2020

Activation and intrinsic gamma-secretase activity of presenilin 1.

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12 December 2020

And four equals one: presenilin takes the gamma-secretase role by itself

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12 December 2020

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

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12 December 2020

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

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12 December 2020

Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation

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12 December 2020

DNA immunization against amyloid beta 42 has high potential as safe therapy for Alzheimer's disease as it diminishes antigen-specific Th1 and Th17 cell proliferation

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12 December 2020

Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

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12 December 2020

Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β

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12 December 2020

Alzheimer's Prevention Initiative: a plan to accelerate the evaluation of presymptomatic treatments

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12 December 2020

Effect of immunotherapy with bapineuzumab on cerebrospinal fluid biomarker levels in patients with mild to moderate Alzheimer disease

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12 December 2020

Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers

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12 December 2020

Amyloid-beta (Aβ) D7H mutation increases oligomeric Aβ42 and alters properties of Aβ-zinc/copper assemblies

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12 December 2020

Safety and biomarker effects of solanezumab in patients with Alzheimer's disease.

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12 December 2020

Clinical and biomarker changes in dominantly inherited Alzheimer's disease

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12 December 2020

An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ.

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12 December 2020

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

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12 December 2020

Alzheimer's research. Stopping Alzheimer's before it starts

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12 December 2020

A peptide prime-DNA boost immunization protocol provides significant benefits as a new generation Aβ42 DNA vaccine for Alzheimer disease.

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12 December 2020

Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network

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12 December 2020

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

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12 December 2020

TREM2 Variants in Alzheimer's Disease

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12 December 2020

NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

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12 December 2020

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

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12 December 2020

Deletion of Abca7 increases cerebral amyloid-β accumulation in the J20 mouse model of Alzheimer's disease

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12 December 2020

Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease

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12 December 2020

Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta

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12 December 2020

DNA Aβ42 vaccination as possible alternative immunotherapy for Alzheimer disease.

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12 December 2020

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

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12 December 2020

Advances in the development of vaccines for Alzheimer's disease

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12 December 2020

Scara1 deficiency impairs clearance of soluble amyloid-β by mononuclear phagocytes and accelerates Alzheimer's-like disease progression

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12 December 2020

CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

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12 December 2020

Anti-amyloid beta to tau - based immunization: Developments in immunotherapy for Alzheimer disease

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12 December 2020

Monoclonal antibodies against Aβ42 fibrils distinguish multiple aggregation state polymorphisms in vitro and in Alzheimer disease brain

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12 December 2020

Co-stimulation with TNF receptor superfamily 4/25 antibodies enhances in-vivo expansion of CD4+CD25+Foxp3+ T cells (Tregs) in a mouse study for active DNA Aβ42 immunotherapy

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12 December 2020

A noninflammatory immune response in aged DNA Aβ42-immunized mice supports its safety for possible use as immunotherapy in AD patients

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12 December 2020

The Human Alzheimer Disease Project: A New Call to Arms.

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12 December 2020

Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model

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12 December 2020

Defining amyloid pathology in persons with and without dementia syndromes: making the right diagnosis.

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12 December 2020

ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing

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12 December 2020

Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway.

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12 December 2020

Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome.

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12 December 2020

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

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12 December 2020

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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12 December 2020

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

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12 December 2020

Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions

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12 December 2020

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

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12 December 2020

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

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12 December 2020

Enhanced release of amyloid beta-protein from codon 670/671 "Swedish" mutant beta-amyloid precursor protein occurs in both secretory and endocytic pathways

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12 December 2020

Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers

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12 December 2020

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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12 December 2020

Amyloid beta-protein and the genetics of Alzheimer's disease

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12 December 2020

New insights into the genetics of Alzheimer's disease

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12 December 2020

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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12 December 2020

Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins

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12 December 2020

A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43)

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12 December 2020

10.1001/JAMANEUROL.2016.0301

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6759853&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6759853&resulttype=core&format=json

12 May 2020

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