(Q38845711)

6 September 2017

title

CP-31398 inhibits the growth of p53-mutated liver cancer cells in vitro and in vivo (English)

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6 September 2017

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Xing-Xing He

1

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6 September 2017

Yu-Nan Zhang

2

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6 September 2017

Jun-Wei Yan

3

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6 September 2017

Jing-Jun Yan

4

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6 September 2017

Qian Wu

5

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6 September 2017

Yu-Hu Song

6

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6 September 2017

publication date

7 August 2015

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6 September 2017

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6 September 2017

volume

37

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6 September 2017

issue

1

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6 September 2017

page(s)

807-815

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6 September 2017

cites work

Global cancer statistics

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21 January 2018

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Management of hepatocellular carcinoma: An update

21 January 2018

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Mutant p53 gain-of-function in cancer

21 January 2018

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The role of mutant p53 in human cancer

21 January 2018

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21 January 2018

p53 mutations in cancer

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https://api.crossref.org/works/10.1007%2FS13277-015-3857-5

Characterization of the p53-rescue drug CP-31398 in vitro and in living cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-015-3857-5

Trans-splicing repair of mutant p53 suppresses the growth of hepatocellular carcinoma cells in vitro and in vivo

21 January 2018

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https://api.crossref.org/works/10.1007%2FS13277-015-3857-5

Functional repair of p53 mutation in colorectal cancer cells using trans-splicing

21 January 2018

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Molecular mechanisms of hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-015-3857-5

Alterations of TP53 are associated with a poor outcome for patients with hepatocellular carcinoma: evidence from a systematic review and meta-analysis

21 January 2018

1 reference

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Restoration of wild-type p53 function in human cancer: relevance for tumor therapy.

21 January 2018

1 reference

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The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through a p53-dependent pathway.

21 January 2018

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Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

21 January 2018

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Rescue of mutant p53 transcription function by ellipticine

21 January 2018

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Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

21 January 2018

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Mutant p53 targeting by the low molecular weight compound STIMA-1

21 January 2018

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Allele-specific p53 mutant reactivation

21 January 2018

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Autophagy induced by p53-reactivating molecules protects pancreatic cancer cells from apoptosis.

21 January 2018

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Chemopreventive effects of the p53-modulating agents CP-31398 and Prima-1 in tobacco carcinogen-induced lung tumorigenesis in A/J mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-015-3857-5

The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein

21 January 2018

1 reference

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CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice

21 January 2018

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Targeting wild-type and mutant p53 with small molecule CP-31398 blocks the growth of rhabdomyosarcoma by inducing reactive oxygen species-dependent apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-015-3857-5

MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo

21 January 2018

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Embryonic liver fodrin involved in hepatic stellate cell activation and formation of regenerative nodule in liver cirrhosis

21 January 2018

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β-2 spectrin is involved in hepatocyte proliferation through the interaction of TGFβ/Smad and PI3K/AKT signalling

21 January 2018

1 reference

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CP-31398 prevents the growth of p53-mutated colorectal cancer cells in vitro and in vivo

21 January 2018

1 reference

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Targeting mutant p53 in human tumors

21 January 2018

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Chinese gene therapy. Splicing out the West?

21 January 2018

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p53-based cancer therapies: Is defective p53 the Achilles heel of the tumor?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-015-3857-5

Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-015-3857-5

p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-015-3857-5

CP-31398 restores DNA-binding activity to mutant p53 in vitro but does not affect p53 homologs p63 and p73

21 January 2018

1 reference

12 December 2020

Mouse models to study the interaction of risk factors for human liver cancer.

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12 December 2020

p53-based cancer therapy

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12 December 2020

Pharmacological rescue of mutant p53 conformation and function

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12 December 2020

10.1007/S13277-015-3857-5

Identifiers

DOI

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Dimensions Publication ID

6 September 2017

1030357822

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