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English
Restoration of wild-type p53 function in human cancer: relevance for tumor therapy.
scientific article published on March 2007
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
17230559
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17230559%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 December 2019
review article
1 reference
stated in
Europe PubMed Central
title
Restoration of wild-type p53 function in human cancer: relevance for tumor therapy
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
17230559
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17230559%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 December 2019
author
Gianluca Bossi
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
17230559
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17230559%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 December 2019
author name string
Ada Sacchi
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
17230559
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17230559%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 December 2019
publication date
1 March 2007
1 reference
stated in
Europe PubMed Central
PubMed ID
17230559
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17230559%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 December 2019
published in
Head & Neck
1 reference
stated in
Europe PubMed Central
PubMed ID
17230559
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17230559%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 December 2019
volume
29
1 reference
stated in
Europe PubMed Central
PubMed ID
17230559
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17230559%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 December 2019
page(s)
272-284
1 reference
stated in
Europe PubMed Central
PubMed ID
17230559
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17230559%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 December 2019
issue
3
1 reference
stated in
Europe PubMed Central
PubMed ID
17230559
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17230559%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 December 2019
cites work
Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
21 January 2018
Cytotoxic effect of a non-peptidic small molecular inhibitor of the p53-HDM2 interaction on tumor cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
21 January 2018
Phase I trial of elactocin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
21 January 2018
T antigen is bound to a host protein in SY40-transformed cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations in the p53 gene occur in diverse human tumour types
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p53 proto-oncogene can act as a suppressor of transformation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Surfing the p53 network
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Presence of a potent transcription activating sequence in the p53 protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Decision making by p53: life, death and cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence that the death receptor DR4 is a DNA damage-inducible, p53-regulated gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PUMA, a novel proapoptotic gene, is induced by p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BID regulation by p53 contributes to chemosensitivity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel form of Epstein-Barr virus latency in normal B cells in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apoptotic threshold is lowered by p53 transactivation of caspase-6
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Apaf-1 is a transcriptional target for E2F and p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Control of apoptosis by p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Promoter-specific p53-dependent histone acetylation following DNA damage.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A novel cofactor for p300 that regulates the p53 response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ASPP proteins specifically stimulate the apoptotic function of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The transcriptional repressor hDaxx potentiates p53-dependent apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 has a direct apoptogenic role at the mitochondria
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a novel p53 functional domain that is necessary for efficient growth suppression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The codon 72 polymorphic variants of p53 have markedly different apoptotic potential
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Therapeutic effect of a retroviral wild-type p53 expression vector in an orthotopic lung cancer model
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of exogenous wt-p53 does not affect normal hematopoiesis: implications for bone marrow purging.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Wild-type p53 gene transfer is not detrimental to normal cells in vivo: implications for tumor gene therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Clinical trials of adenoviruses in brain tumors: a review of Ad-p53 and oncolytic adenoviruses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Why did p53 gene therapy fail in ovarian cancer?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
China approves first gene therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Modified adenoviruses for cancer gene therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The MDM2 gene amplification database
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functions of the MDM2 oncoprotein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p53-mdm-2 autoregulatory feedback loop
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mdm2 promotes the rapid degradation of p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of p53 stability by Mdm2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The MDM2 RING-finger domain is required to promote p53 nuclear export
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ubiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Novel antisense anti-MDM2 mixed-backbone oligonucleotides: proof of principle, in vitro and in vivo activities, and mechanisms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chemosensitization and radiosensitization of human cancer by antisense anti-MDM2 oligonucleotides: in vitro and in vivo activities and mechanisms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chemosensitization by antisense oligonucleotides targeting MDM2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibiting the p53-MDM2 interaction: an important target for cancer therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Discovery of potent antagonists of the interaction between human double minute 2 and tumor suppressor p53
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Study of the cytotoxic effect of a peptidic inhibitor of the p53-hdm2 interaction in tumor cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Isolation and structure elucidation of Chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The initial evaluation of non-peptidic small-molecule HDM2 inhibitors based on p53-HDM2 complex structure
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteasome inhibition: a novel approach to cancer therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A phase 2 study of bortezomib in relapsed, refractory myeloma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p53-Mdm2 module and the ubiquitin system.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Higher order chromosome structure is affected by cold-sensitive mutations in a Schizosaccharomyces pombe gene crm1+ which encodes a 115-kD protein preferentially localized in the nucleus and its periphery
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Accumulating active p53 in the nucleus by inhibition of nuclear export: a novel strategy to promote the p53 tumor suppressor function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of p53 in cervical carcinoma cells by small molecules.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Leptomycin B stabilizes and activates p53 in primary prostatic epithelial cells and induces apoptosis in the LNCaP cell line
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The IARC TP53 database: new online mutation analysis and recommendations to users
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rescuing the function of mutant p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Drug discovery and p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An adenovirus mutant that replicates selectively in p53-deficient human tumor cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Replication of an E1B 55-kilodalton protein-deficient adenovirus (ONYX-015) is restored by gain-of-function rather than loss-of-function p53 mutants
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pharmacological rescue of mutant p53 conformation and function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A fly with an ointment: Bcl-2 as an anti-mutator in tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of the p53-rescue drug CP-31398 in vitro and in living cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CP-31398 restores DNA-binding activity to mutant p53 in vitro but does not affect p53 homologs p63 and p73
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Small molecules that reactivate mutant p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selective induction of apoptosis in mutant p53 premalignant and malignant cancer cells by PRIMA-1 through the c-Jun-NH2-kinase pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural distortion of p53 by the mutation R249S and its rescue by a designed peptide: implications for "mutant conformation".
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Kinetic Instability of p53 Core Domain Mutants
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ASPP1 and ASPP2: common activators of p53 family members
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hsp90 inhibitors as novel cancer chemotherapeutic agents
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mining the National Cancer Institute Anticancer Drug Discovery Database: cluster analysis of ellipticine analogs with p53-inverse and central nervous system-selective patterns of activity.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rescue of mutant p53 transcription function by ellipticine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ribozyme-mediated induction of apoptosis in human cancer cells by targeted repair of mutant p53 RNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1002/HED.20529
1 reference
stated in
Europe PubMed Central
PubMed ID
17230559
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17230559%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 December 2019
PubMed ID
17230559
1 reference
stated in
Europe PubMed Central
PubMed ID
17230559
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17230559%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 December 2019
ResearchGate publication ID
6571236
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