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Restoration of wild-type p53 function in human cancer: relevance for tumor therapy.
scientific article published on March 2007
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17230559
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17230559%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 December 2019
review article
1 reference
stated in
Europe PubMed Central
title
Restoration of wild-type p53 function in human cancer: relevance for tumor therapy
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17230559
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17230559%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 December 2019
author
Gianluca Bossi
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17230559
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17230559%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 December 2019
author name string
Ada Sacchi
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17230559
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17230559%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 December 2019
publication date
1 March 2007
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17230559
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17230559%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 December 2019
published in
Head & Neck
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17230559
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17230559%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 December 2019
volume
29
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17230559
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17230559%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 December 2019
issue
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17230559
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17230559%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 December 2019
page(s)
272-284
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17230559
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17230559%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 December 2019
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NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription
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Decision making by p53: life, death and cancer
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Evidence that the death receptor DR4 is a DNA damage-inducible, p53-regulated gene
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KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene
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7 January 2021
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The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract
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The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis
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7 January 2021
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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
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7 January 2021
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PUMA, a novel proapoptotic gene, is induced by p53
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7 January 2021
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BID regulation by p53 contributes to chemosensitivity
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7 January 2021
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A novel form of Epstein-Barr virus latency in normal B cells in vivo
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7 January 2021
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Apoptotic threshold is lowered by p53 transactivation of caspase-6
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Apaf-1 is a transcriptional target for E2F and p53
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Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis
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p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53
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7 January 2021
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7 January 2021
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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.
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PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy
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p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells
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A novel cofactor for p300 that regulates the p53 response
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ASPP proteins specifically stimulate the apoptotic function of p53
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Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.
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The transcriptional repressor hDaxx potentiates p53-dependent apoptosis
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7 January 2021
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p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
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Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling
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p53 has a direct apoptogenic role at the mitochondria
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Identification of a novel p53 functional domain that is necessary for efficient growth suppression
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The codon 72 polymorphic variants of p53 have markedly different apoptotic potential
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A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
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Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers.
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Therapeutic effect of a retroviral wild-type p53 expression vector in an orthotopic lung cancer model
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7 January 2021
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Expression of exogenous wt-p53 does not affect normal hematopoiesis: implications for bone marrow purging.
1 reference
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7 January 2021
based on heuristic
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Wild-type p53 gene transfer is not detrimental to normal cells in vivo: implications for tumor gene therapy
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7 January 2021
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Clinical trials of adenoviruses in brain tumors: a review of Ad-p53 and oncolytic adenoviruses
1 reference
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7 January 2021
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Why did p53 gene therapy fail in ovarian cancer?
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7 January 2021
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China approves first gene therapy
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7 January 2021
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Modified adenoviruses for cancer gene therapy
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7 January 2021
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The MDM2 gene amplification database
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7 January 2021
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Functions of the MDM2 oncoprotein
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7 January 2021
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The p53-mdm-2 autoregulatory feedback loop
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7 January 2021
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Mdm2 promotes the rapid degradation of p53
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7 January 2021
based on heuristic
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Regulation of p53 stability by Mdm2
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7 January 2021
based on heuristic
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The MDM2 RING-finger domain is required to promote p53 nuclear export
1 reference
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7 January 2021
based on heuristic
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Ubiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression.
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7 January 2021
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Novel antisense anti-MDM2 mixed-backbone oligonucleotides: proof of principle, in vitro and in vivo activities, and mechanisms
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7 January 2021
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Chemosensitization and radiosensitization of human cancer by antisense anti-MDM2 oligonucleotides: in vitro and in vivo activities and mechanisms
1 reference
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7 January 2021
based on heuristic
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Chemosensitization by antisense oligonucleotides targeting MDM2.
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibiting the p53-MDM2 interaction: an important target for cancer therapy
1 reference
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7 January 2021
based on heuristic
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Discovery of potent antagonists of the interaction between human double minute 2 and tumor suppressor p53
1 reference
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Study of the cytotoxic effect of a peptidic inhibitor of the p53-hdm2 interaction in tumor cells
1 reference
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7 January 2021
based on heuristic
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Isolation and structure elucidation of Chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp.
1 reference
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https://api.crossref.org/works/10.1002%2FHED.20529
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7 January 2021
based on heuristic
inferred from DOI database lookup
The initial evaluation of non-peptidic small-molecule HDM2 inhibitors based on p53-HDM2 complex structure
1 reference
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https://api.crossref.org/works/10.1002%2FHED.20529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53.
1 reference
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https://api.crossref.org/works/10.1002%2FHED.20529
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7 January 2021
based on heuristic
inferred from DOI database lookup
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
1 reference
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https://api.crossref.org/works/10.1002%2FHED.20529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.
1 reference
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https://api.crossref.org/works/10.1002%2FHED.20529
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7 January 2021
based on heuristic
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Proteasome inhibition: a novel approach to cancer therapy
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7 January 2021
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A phase 2 study of bortezomib in relapsed, refractory myeloma
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7 January 2021
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The p53-Mdm2 module and the ubiquitin system.
1 reference
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https://api.crossref.org/works/10.1002%2FHED.20529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors
1 reference
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https://api.crossref.org/works/10.1002%2FHED.20529
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7 January 2021
based on heuristic
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Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells
1 reference
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Crossref
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https://api.crossref.org/works/10.1002%2FHED.20529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Higher order chromosome structure is affected by cold-sensitive mutations in a Schizosaccharomyces pombe gene crm1+ which encodes a 115-kD protein preferentially localized in the nucleus and its periphery
1 reference
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7 January 2021
based on heuristic
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Accumulating active p53 in the nucleus by inhibition of nuclear export: a novel strategy to promote the p53 tumor suppressor function
1 reference
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7 January 2021
based on heuristic
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Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B.
1 reference
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https://api.crossref.org/works/10.1002%2FHED.20529
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7 January 2021
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Activation of p53 in cervical carcinoma cells by small molecules.
1 reference
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https://api.crossref.org/works/10.1002%2FHED.20529
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7 January 2021
based on heuristic
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Leptomycin B stabilizes and activates p53 in primary prostatic epithelial cells and induces apoptosis in the LNCaP cell line
1 reference
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Crossref
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https://api.crossref.org/works/10.1002%2FHED.20529
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7 January 2021
based on heuristic
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Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy
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based on heuristic
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The IARC TP53 database: new online mutation analysis and recommendations to users
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7 January 2021
based on heuristic
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Rescuing the function of mutant p53.
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7 January 2021
based on heuristic
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Drug discovery and p53.
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy
1 reference
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https://api.crossref.org/works/10.1002%2FHED.20529
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7 January 2021
based on heuristic
inferred from DOI database lookup
An adenovirus mutant that replicates selectively in p53-deficient human tumor cells
1 reference
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https://api.crossref.org/works/10.1002%2FHED.20529
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7 January 2021
based on heuristic
inferred from DOI database lookup
ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents
1 reference
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https://api.crossref.org/works/10.1002%2FHED.20529
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7 January 2021
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inferred from DOI database lookup
Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015).
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Replication of an E1B 55-kilodalton protein-deficient adenovirus (ONYX-015) is restored by gain-of-function rather than loss-of-function p53 mutants
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain
1 reference
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Crossref
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https://api.crossref.org/works/10.1002%2FHED.20529
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7 January 2021
based on heuristic
inferred from DOI database lookup
Pharmacological rescue of mutant p53 conformation and function
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
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7 January 2021
based on heuristic
inferred from DOI database lookup
A fly with an ointment: Bcl-2 as an anti-mutator in tumors
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reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of the p53-rescue drug CP-31398 in vitro and in living cells.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CP-31398 restores DNA-binding activity to mutant p53 in vitro but does not affect p53 homologs p63 and p73
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Small molecules that reactivate mutant p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selective induction of apoptosis in mutant p53 premalignant and malignant cancer cells by PRIMA-1 through the c-Jun-NH2-kinase pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural distortion of p53 by the mutation R249S and its rescue by a designed peptide: implications for "mutant conformation".
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A peptide that binds and stabilizes p53 core domain: chaperone strategy for rescue of oncogenic mutants
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Kinetic Instability of p53 Core Domain Mutants
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ASPP1 and ASPP2: common activators of p53 family members
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hsp90 inhibitors as novel cancer chemotherapeutic agents
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mining the National Cancer Institute Anticancer Drug Discovery Database: cluster analysis of ellipticine analogs with p53-inverse and central nervous system-selective patterns of activity.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rescue of mutant p53 transcription function by ellipticine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ribozyme-mediated induction of apoptosis in human cancer cells by targeted repair of mutant p53 RNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHED.20529
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1002/HED.20529
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17230559
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17230559%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 December 2019
PubMed publication ID
17230559
1 reference
stated in
Europe PubMed Central
PubMed publication ID
17230559
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17230559%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 December 2019
ResearchGate publication ID
6571236
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