(Q38850026)

7 September 2017

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title

Next stop for the CRISPR revolution: RNA-guided epigenetic regulators (English)

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7 September 2017

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George Church

4

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author name string

Suhani Vora

series ordinal

1

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7 September 2017

Marcelle Tuttle

series ordinal

2

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7 September 2017

Jenny Cheng

series ordinal

3

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7 September 2017

language of work or name

English

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publication date

1 June 2016

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7 September 2017

13

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based on heuristic

inferred from page(s)

published in

FEBS Journal

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7 September 2017

283

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7 September 2017

17

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7 September 2017

3181-3193

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Epigenetic reprogramming of cancer cells via targeted DNA methylation.

7 September 2017

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Gene-specific targeting of H3K9 methylation is sufficient for initiating repression in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Locus-specific editing of histone modifications at endogenous enhancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Robust, synergistic regulation of human gene expression using TALE activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Synergistic and tunable human gene activation by combinations of synthetic transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

TALE-mediated epigenetic suppression of CDKN2A increases replication in human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Designer zinc finger proteins: tools for creating artificial DNA-binding functional proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

FLASH assembly of TALENs for high-throughput genome editing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Identification of 86 candidates for small non-messenger RNAs from the archaeon Archaeoglobus fulgidus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Small CRISPR RNAs guide antiviral defense in prokaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

An updated evolutionary classification of CRISPR-Cas systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Multiplex genome engineering using CRISPR/Cas systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

RNA-guided human genome engineering via Cas9

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

RNA-programmed genome editing in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Phage response to CRISPR-encoded resistance in Streptococcus thermophilus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Short motif sequences determine the targets of the prokaryotic CRISPR defence system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Genome engineering using the CRISPR-Cas9 system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Large-scale de novo DNA synthesis: technologies and applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

CRISPR-Cas systems for editing, regulating and targeting genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Use of designer nucleases for targeted gene and genome editing in plants

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

CRISPR RNA-guided activation of endogenous human genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

RNA-guided gene activation by CRISPR-Cas9-based transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

A CRISPR/Cas9-based system for reprogramming cell lineage specification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

A protein-tagging system for signal amplification in gene expression and fluorescence imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Highly efficient Cas9-mediated transcriptional programming

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Functional annotation of native enhancers with a Cas9-histone demethylase fusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Cas9 gRNA engineering for genome editing, activation and repression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Conformational control of DNA target cleavage by CRISPR-Cas9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

CRISPR-Cas9 knockin mice for genome editing and cancer modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

In vivo genome editing using Staphylococcus aureus Cas9

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

DNA targeting specificity of RNA-guided Cas9 nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Unraveling CRISPR-Cas9 genome engineering parameters via a library-on-library approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

WU-CRISPR: characteristics of functional guide RNAs for the CRISPR/Cas9 system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Review of the clinical development of alipogene tiparvovec gene therapy for lipoprotein lipase deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Orthogonal Cas9 proteins for RNA-guided gene regulation and editing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Comparison of TALE designer transcription factors and the CRISPR/dCas9 in regulation of gene expression by targeting enhancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

CRISPR-mediated Activation of Latent HIV-1 Expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

CRISPR/gRNA-directed synergistic activation mediator (SAM) induces specific, persistent and robust reactivation of the HIV-1 latent reservoirs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

In Vivo Transcriptional Activation Using CRISPR/Cas9 in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Epigenetic regulation by long noncoding RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

In vivo gene editing in dystrophic mouse muscle and muscle stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

Spell Checking Nature: Versatility of CRISPR/Cas9 for Developing Treatments for Inherited Disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13768

21 January 2018

Identifiers

DOI

10.1111/FEBS.13768

1 reference

7 September 2017

1 reference