(Q38850597)

7 September 2017

title

Metabolite profiling of CHO cells: Molecular reflections of bioprocessing effectiveness (English)

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Royston Goodacre

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7 September 2017

author name string

Christopher A Sellick

1

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7 September 2017

Alexandra S Croxford

2

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Arfa R Maqsood

3

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Gill M Stephens

4

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Alan J Dickson

7

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publication date

14 July 2015

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7 September 2017

published in

Biotechnology Journal

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7 September 2017

volume

10

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issue

9

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7 September 2017

page(s)

1434-1445

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Production of recombinant protein therapeutics in cultivated mammalian cells

7 September 2017

cites work

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https://api.crossref.org/works/10.1002%2FBIOT.201400664

Mammalian stable expression of biotherapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

Understanding the intracellular effect of enhanced nutrient feeding toward high titer antibody production process

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

Metabolite profiling of recombinant CHO cells: designing tailored feeding regimes that enhance recombinant antibody production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

A single nutrient feed supports both chemically defined NS0 and CHO fed-batch processes: Improved productivity and lactate metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

Strategies for selecting recombinant CHO cell lines for cGMP manufacturing: realizing the potential in bioreactors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

In situ monitoring of intracellular glucose and glutamine in CHO cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

Metabolic responses of CHO cells to limitation of key amino acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

Metabolomics-based identification of apoptosis-inducing metabolites in recombinant fed-batch CHO culture media.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

Metabolite profiling of CHO cells with different growth characteristics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

Metabolic signatures of GS-CHO cell clones associated with butyrate treatment and culture phase transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

Probing the metabolism of an inducible mammalian expression system using extracellular isotopomer analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

LC-MS-based metabolic characterization of high monoclonal antibody-producing Chinese hamster ovary cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

Metabolic analysis of antibody producing CHO cells in fed-batch production

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

Metabolomics-driven approach for the improvement of Chinese hamster ovary cell growth: overexpression of malate dehydrogenase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

Combined in silico modeling and metabolomics analysis to characterize fed-batch CHO cell culture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

Parallel labeling experiments with [1,2-(13)C]glucose and [U-(13)C]glutamine provide new insights into CHO cell metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

Effective quenching processes for physiologically valid metabolite profiling of suspension cultured Mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

Metabolite extraction from suspension-cultured mammalian cells for global metabolite profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

Strategies for selecting recombinant CHO cell lines for cGMP manufacturing: improving the efficiency of cell line generation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture process

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

Correlation of antibody production rate with glucose and lactate metabolism in Chinese hamster ovary cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

On metabolic shift to lactate consumption in fed-batch culture of mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

Evidence for intracellular partitioning of serine and glycine metabolism in Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

Amino acids and mTOR signalling in anabolic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

Metabolic control at the cytosol-mitochondria interface in different growth phases of CHO cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

Dynamic model of CHO cell metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

Flux balance analysis of CHO cells before and after a metabolic switch from lactate production to consumption

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FBIOT.201400664

Analysis of Chinese hamster ovary cell metabolism through a combined computational and experimental approach

21 January 2018

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https://api.crossref.org/works/10.1002%2FBIOT.201400664

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Identifiers

DOI

10.1002/BIOT.201400664

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7 September 2017

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