(Q38872254)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25998442%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

title

PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25998442%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25998442%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Marie K Holt

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25998442%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Rafal Czapiewski

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25998442%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Wei Cui

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25998442%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

author name string

Thamil Selvee Ramasamy

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25998442%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Nick Murphy

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25998442%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Shi-Khai Wei

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25998442%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

language of work or name

English

0 references

publication date

22 May 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25998442%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

published in

Nature Communications

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25998442%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

volume

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25998442%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

page(s)

7212

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25998442%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

8 March 2020

copyright license

start time

22 May 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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9 September 2017

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9 September 2017

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9 September 2017

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mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

9 September 2017

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Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling

9 September 2017

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Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways

9 September 2017

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TGF-beta signalling is regulated by Schnurri-2-dependent nuclear translocation of CLIC4 and consequent stabilization of phospho-Smad2 and 3

9 September 2017

1 reference

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mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells

9 September 2017

1 reference

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Phospho-control of TGF-beta superfamily signaling

9 September 2017

1 reference

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Signaling cross-talk between TGF-beta/BMP and other pathways

9 September 2017

1 reference

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

9 September 2017

1 reference

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How the Smads regulate transcription

9 September 2017

1 reference

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TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility

9 September 2017

1 reference

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A ROCK inhibitor permits survival of dissociated human embryonic stem cells

9 September 2017

1 reference

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Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability

9 September 2017

1 reference

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PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling

9 September 2017

1 reference

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

9 September 2017

1 reference

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Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation

9 September 2017

1 reference

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Efficient differentiation of human embryonic stem cells to definitive endoderm

9 September 2017

1 reference

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Specificity and versatility in tgf-beta signaling through Smads

9 September 2017

1 reference

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

9 September 2017

1 reference

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Stably transfected human embryonic stem cell clones express OCT4-specific green fluorescent protein and maintain self-renewal and pluripotency

9 September 2017

1 reference

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

9 September 2017

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

9 September 2017

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Transcriptional control by the TGF-beta/Smad signaling system

9 September 2017

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A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

9 September 2017

1 reference

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Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

9 September 2017

1 reference

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Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-β pathway

9 September 2017

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9 September 2017

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Role of Rho/ROCK and p38 MAP kinase pathways in transforming growth factor-beta-mediated Smad-dependent growth inhibition of human breast carcinoma cells in vivo

14 September 2017

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Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis

14 September 2017

1 reference

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PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3.

14 September 2017

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Development of definitive endoderm from embryonic stem cells in culture

14 September 2017

1 reference

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Ubiquitin-dependent degradation of TGF-beta-activated smad2.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4455068

Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4455068

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4

17 June 2018

1 reference

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Where PI3K/Akt meets Smads: the crosstalk determines human embryonic stem cell fate

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4455068

Efficient differentiation of hepatocytes from human embryonic stem cells exhibiting markers recapitulating liver development in vivo.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4455068

Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4455068

Acceleration of Smad2 and Smad3 phosphorylation via c-Jun NH(2)-terminal kinase during human colorectal carcinogenesis.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4455068

Cyclin-dependent kinases regulate the antiproliferative function of Smads

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4455068

Nuclear exclusion of Smad2 is a mechanism leading to loss of competence

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4455068

Suppression of transforming growth factor-beta-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway

22 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25998442

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCOMMS8212

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25998442%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

8 March 2020

ADS bibcode

2015NatCo...6.7212Y

0 references

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25998442%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

PubMed publication ID

25998442

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25998442%20AND%20SRC:MED&resulttype=core&format=json