(Q38878056)

7 September 2017

title

Translational value of mouse models in oncology drug development (English)

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7 September 2017

1

Stephen E Gould

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author name string

Melissa R Junttila

series ordinal

2

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7 September 2017

Frederic J de Sauvage

series ordinal

3

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7 September 2017

language of work or name

English

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publication date

1 May 2015

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7 September 2017

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7 September 2017

volume

21

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7 September 2017

issue

5

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7 September 2017

page(s)

431-439

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https://scigraph.springernature.com/pub.10.1038/nm.3853

7 September 2017

exact match

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cites work

Clinical development success rates for investigational drugs

1 reference

Genome editing. The new frontier of genome engineering with CRISPR-Cas9

21 January 2018

1 reference

Stable RNA interference rules for silencing

21 January 2018

1 reference

CRISPR-mediated direct mutation of cancer genes in the mouse liver

21 January 2018

1 reference

Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype.

21 January 2018

1 reference

Rapid modelling of cooperating genetic events in cancer through somatic genome editing

21 January 2018

1 reference

Patient-derived xenograft models: an emerging platform for translational cancer research

21 January 2018

1 reference

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

21 January 2018

1 reference

Evaluating cell lines as tumour models by comparison of genomic profiles

21 January 2018

1 reference

Parallel progression of primary tumours and metastases

21 January 2018

1 reference

Influence of tumour micro-environment heterogeneity on therapeutic response

21 January 2018

1 reference

A pilot clinical study of treatment guided by personalized tumorgrafts in patients with advanced cancer

21 January 2018

1 reference

Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomes

21 January 2018

1 reference

Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts

21 January 2018

1 reference

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution.

21 January 2018

1 reference

Molecular pathways: response and resistance to BRAF and MEK inhibitors in BRAF(V600E) tumors

21 January 2018

1 reference

Characterization of a large panel of patient-derived tumor xenografts representing the clinical heterogeneity of human colorectal cancer

21 January 2018

1 reference

KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.

21 January 2018

1 reference

Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer

21 January 2018

1 reference

Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation.

21 January 2018

1 reference

The mutational landscapes of genetic and chemical models of Kras-driven lung cancer

21 January 2018

1 reference

Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing.

21 January 2018

1 reference

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

21 January 2018

1 reference

Genetic basis for clinical response to CTLA-4 blockade in melanoma

21 January 2018

1 reference

Of mice and not men: differences between mouse and human immunology

21 January 2018

1 reference

Antigen cross-presentation of immune complexes

21 January 2018

1 reference

T cell genetic background determines default T helper phenotype development in vitro

21 January 2018

1 reference

Current advances in humanized mouse models

21 January 2018

1 reference

Humanized mice for immune system investigation: progress, promise and challenges

21 January 2018

1 reference

Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells.

21 January 2018

1 reference

Genetically engineered mouse models: closing the gap between preclinical data and trial outcomes

21 January 2018

1 reference

Stage-specific sensitivity to p53 restoration during lung cancer progression.

21 January 2018

1 reference

Restoration of p53 function leads to tumour regression in vivo

21 January 2018

1 reference

Modeling the therapeutic efficacy of p53 restoration in tumors

21 January 2018

1 reference

Selective activation of p53-mediated tumour suppression in high-grade tumours

21 January 2018

1 reference

Development of a second-generation antiandrogen for treatment of advanced prostate cancer

21 January 2018

1 reference

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

21 January 2018

1 reference

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

21 January 2018

1 reference

A comprehensive transcriptional portrait of human cancer cell lines

21 January 2018

1 reference

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.

21 January 2018

1 reference

Insensitivity of human prolactin receptors to nonhuman prolactins: relevance for experimental modeling of prolactin receptor-expressing human cells

21 January 2018

1 reference

Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models

21 January 2018

1 reference

CTLA-4 and PD-1/PD-L1 blockade: new immunotherapeutic modalities with durable clinical benefit in melanoma patients

21 January 2018

1 reference

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

21 January 2018

1 reference

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

21 January 2018

1 reference

Antitumor efficacy of a bispecific antibody that targets HER2 and activates T cells

21 January 2018

1 reference

Rebuilding cancer metastasis in the mouse

21 January 2018

1 reference

Mouse models of advanced spontaneous metastasis for experimental therapeutics

21 January 2018

1 reference

Genes that mediate breast cancer metastasis to the brain

21 January 2018

1 reference

Genes that mediate breast cancer metastasis to lung

21 January 2018

1 reference

Lymph node-independent liver metastasis in a model of metastatic colorectal cancer

21 January 2018

1 reference

New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)

21 January 2018

1 reference

Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials

21 January 2018

1 reference

Antitumor activity of targeted and cytotoxic agents in murine subcutaneous tumor models correlates with clinical response

21 January 2018

1 reference

A paracrine requirement for hedgehog signalling in cancer

21 January 2018

1 reference

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

21 January 2018

1 reference

Pharmacokinetic-pharmacodynamic analysis of vismodegib in preclinical models of mutational and ligand-dependent Hedgehog pathway activation

21 January 2018

1 reference

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

21 January 2018

1 reference

A randomized phase II trial of vismodegib versus placebo with FOLFOX or FOLFIRI and bevacizumab in patients with previously untreated metastatic colorectal cancer

21 January 2018

1 reference

Bridging the gap between preclinical and clinical studies using pharmacokinetic-pharmacodynamic modeling: an analysis of GDC-0973, a MEK inhibitor

21 January 2018

1 reference

Pharmacodynamics of 2-[4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridine-4-yl)-1H-pyrazol-1-yl]ethan-1-ol (GDC-0879), a potent and selective B-Raf kinase inhibitor: understanding relationships between systemic concentrations, phosphory

21 January 2018

1 reference

Guidelines for the welfare and use of animals in cancer research

21 January 2018

1 reference

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

21 January 2018

1 reference

Tumour heterogeneity in the clinic

21 January 2018

1 reference

Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity

21 January 2018

1 reference

21 January 2018

1 reference

Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing

21 January 2018

1 reference

CRISPR-Cas9 knockin mice for genome editing and cancer modeling

21 January 2018

1 reference

Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis

21 January 2018

1 reference

Organogenesis in a dish: modeling development and disease using organoid technologies

21 January 2018

1 reference

Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture

21 January 2018

1 reference

Organoid cultures derived from patients with advanced prostate cancer

21 January 2018

1 reference

Organoid models of human and mouse ductal pancreatic cancer

21 January 2018

1 reference

Absence of Thymus in a Mouse Mutant

21 January 2018

1 reference

Preclinical research: Make mouse studies work

21 January 2018

1 reference

Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas

21 January 2018

1 reference

12 December 2020

Heterotransplantation of a human malignant tumour to "Nude" mice

1 reference

12 December 2020

Opinion: Comparative biology of mouse versus human cells: modelling human cancer in mice

1 reference

12 December 2020

Phase I study of vismodegib in children with recurrent or refractory medulloblastoma: a pediatric brain tumor consortium study

1 reference

12 December 2020

CTLA-4 blockade in tumor models: an overview of preclinical and translational research

1 reference

12 December 2020

Prioritizing therapeutic targets using patient-derived xenograft models

1 reference

12 December 2020

Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids.

1 reference

12 December 2020

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

1 reference

12 December 2020

Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells

1 reference

12 December 2020

Genome engineering: the next genomic revolution

1 reference

12 December 2020

Clinical predictive value of the in vitro cell line, human xenograft, and mouse allograft preclinical cancer models

1 reference

12 December 2020

Identifiers

DOI

10.1038/NM.3853

1 reference

release_aguqy7rwo5eotb3igx7uiztye4

7 September 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/aguqy7rwo5eotb3igx7uiztye4

24 November 2022

mapped directly with Wikidata item

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