(Q38887214)

7 September 2017

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title

Insights into microbial cryptic gene activation and strain improvement: principle, application and technical aspects (English)

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7 September 2017

Kozo Ochi

1

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7 September 2017

publication date

6 July 2016

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The Journal of Antibiotics

7 September 2017

published in

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7 September 2017

volume

70

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7 September 2017

issue

1

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7 September 2017

page(s)

25-40

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Fungal secondary metabolites - strategies to activate silent gene clusters

7 September 2017

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Silent clusters - speak up!

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Strain improvement in actinomycetes in the postgenomic era.

21 January 2018

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The Sound of Silence: Activating Silent Biosynthetic Gene Clusters in Marine Microorganisms

21 January 2018

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Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms.

21 January 2018

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Future potential for anti-infectives from bacteria - how to exploit biodiversity and genomic potential

21 January 2018

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Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways

21 January 2018

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Triggers and cues that activate antibiotic production by actinomycetes

21 January 2018

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New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters

21 January 2018

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Towards a new science of secondary metabolism

21 January 2018

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Elicitation of secondary metabolism in actinomycetes.

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2016.82

Big effects from small changes: possible ways to explore nature's chemical diversity.

21 January 2018

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Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistance in Streptomyces lividans and Streptomyces coelicolor A3(2).

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2016.82

EshA accentuates ppGpp accumulation and is conditionally required for antibiotic production in Streptomyces coelicolor A3(2)

21 January 2018

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Structural basis for transcription regulation by alarmone ppGpp.

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2016.82

A rifampicin resistance mutation in the rpoB gene confers ppGpp-independent antibiotic production in Streptomyces coelicolor A3(2).

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2016.82

Genetic and physiological characterization of rpoB mutations that activate antibiotic production in Streptomyces lividans

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2016.82

Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12.

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2016.82

Activation of antibiotic biosynthesis by specified mutations in the rpoB gene (encoding the RNA polymerase beta subunit) of Streptomyces lividans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Streptomycin-resistant (rpsL) or rifampicin-resistant (rpoB) mutation in Pseudomonas putida KH146-2 confers enhanced tolerance to organic chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Improvement of alpha-amylase production by modulation of ribosomal component protein S12 in Bacillus subtilis 168.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Dramatic activation of antibiotic production in Streptomyces coelicolor by cumulative drug resistance mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Activation of Antibiotic Production in Bacillus spp. by Cumulative Drug Resistance Mutations

21 January 2018

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https://api.crossref.org/works/10.1038%2FJA.2016.82

Innovative approach for improvement of an antibiotic-overproducing industrial strain of Streptomyces albus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Activation of the dormant secondary metabolite production by introducing gentamicin-resistance in a marine-derived Penicillium purpurogenum G59

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Identification of novel mureidomycin analogues via rational activation of a cryptic gene cluster in Streptomyces roseosporus NRRL 15998.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Rare earth elements activate the secondary metabolite-biosynthetic gene clusters in Streptomyces coelicolor A3(2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Activation and products of the cryptic secondary metabolite biosynthetic gene clusters by rifampin resistance (rpoB) mutations in actinomycetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Scandium stimulates the production of amylase and bacilysin in Bacillus subtilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Undecaprenyl pyrophosphate involvement in susceptibility of Bacillus subtilis to rare earth elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

The world of subinhibitory antibiotic concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Effects of subinhibitory concentrations of antibiotics on SOS and DNA repair gene expression in Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Lincomycin at Subinhibitory Concentrations Potentiates Secondary Metabolite Production by Streptomyces spp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

High-throughput platform for the discovery of elicitors of silent bacterial gene clusters

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Activating the expression of bacterial cryptic genes by rpoB mutations in RNA polymerase or by rare earth elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Functional characterization of a Penicillium chrysogenum mutanase gene induced upon co-cultivation with Bacillus subtilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Inducing secondary metabolite production by the endophytic fungus Fusarium tricinctum through coculture with Bacillus subtilis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Mycolic acid-containing bacteria induce natural-product biosynthesis in Streptomyces species

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Arcyriaflavin E, a new cytotoxic indolocarbazole alkaloid isolated by combined-culture of mycolic acid-containing bacteria and Streptomyces cinnamoneus NBRC 13823.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Co-cultivation--a powerful emerging tool for enhancing the chemical diversity of microorganisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

New developments in microbial interspecies signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Metabolite induction via microorganism co-culture: a potential way to enhance chemical diversity for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Histone acetylation in chromatin structure and transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

The chromatin code of fungal secondary metabolite gene clusters

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Chromatin-level regulation of biosynthetic gene clusters

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Epigenome manipulation as a pathway to new natural product scaffolds and their congeners

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

LaeA, a regulator of secondary metabolism in Aspergillus spp

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Use and Discovery of Chemical Elicitors That Stimulate Biosynthetic Gene Clusters in Streptomyces Bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Chemical induction of silent biosynthetic pathway transcription in Aspergillus niger.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Loss of CclA, required for histone 3 lysine 4 methylation, decreases growth but increases secondary metabolite production in Aspergillus fumigatus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Epigenetic gene regulation in the bacterial world

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

DNA methylation landscapes: provocative insights from epigenomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Insights into naturally minimised Streptomyces albus J1074 genome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Heterologous expression of natural product biosynthetic gene clusters in Streptomyces coelicolor: from genome mining to manipulation of biosynthetic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Overproduction of Ristomycin A by activation of a silent gene cluster in Amycolatopsis japonicum MG417-CF17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

A new high-performance heterologous fungal expression system based on regulatory elements from the Aspergillus terreus terrein gene cluster.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Refactoring the silent spectinabilin gene cluster using a plug-and-play scaffold

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Recent advances in genome mining of secondary metabolite biosynthetic gene clusters and the development of heterologous expression systems in Aspergillus nidulans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Actinomycetes biosynthetic potential: how to bridge in silico and in vivo?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Reinvigorating natural product combinatorial biosynthesis with synthetic biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Activating secondary metabolism with stress and chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Chemical perturbation of secondary metabolism demonstrates important links to primary metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Natural products and synthetic biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Emerging mass spectrometry techniques for the direct analysis of microbial colonies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Imaging mass spectrometry reveals highly specific interactions between actinomycetes to activate specialized metabolic gene clusters

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Imaging mass spectrometry and genome mining via short sequence tagging identified the anti-infective agent arylomycin in Streptomyces roseosporus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

From microbial differentiation to ribosome engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Streptomycin resistance in mycobacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Novel mutation in 16S rRNA associated with streptomycin dependence in Mycobacterium tuberculosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Structural insights into translational fidelity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Mutations in rsmG, encoding a 16S rRNA methyltransferase, result in low-level streptomycin resistance and antibiotic overproduction in Streptomyces coelicolor A3(2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Identification of the RsmG methyltransferase target as 16S rRNA nucleotide G527 and characterization of Bacillus subtilis rsmG mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

An aberrant protein synthesis activity is linked with antibiotic overproduction in rpsL mutants of Streptomyces coelicolor A3(2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Increased expression of ribosome recycling factor is responsible for the enhanced protein synthesis during the late growth phase in an antibiotic-overproducing Streptomyces coelicolor ribosomal rpsL mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

The novel mutation K87E in ribosomal protein S12 enhances protein synthesis activity during the late growth phase in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Enhanced expression of S-adenosylmethionine synthetase causes overproduction of actinorhodin in Streptomyces coelicolor A3(2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Accumulation of S-adenosyl-L-methionine enhances production of actinorhodin but inhibits sporulation in Streptomyces lividans TK23.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Widespread activation of antibiotic biosynthesis by S-adenosylmethionine in streptomycetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

The mthA mutation conferring low-level resistance to streptomycin enhances antibiotic production in Bacillus subtilis by increasing the S-adenosylmethionine pool size

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Conversion of methionine to cysteine in Bacillus subtilis and its regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Novel links between antibiotic resistance and antibiotic production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Methylthioadenosine/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Guanine nucleotides guanosine 5'-diphosphate 3'-diphosphate and GTP co-operatively regulate the production of an antibiotic bacilysin in Bacillus subtilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

RNA Polymerase Mutation Activates the Production of a Dormant Antibiotic 3,3′-Neotrehalosadiamine via an Autoinduction Mechanism in Bacillus subtilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Regulation of secondary metabolism in streptomycetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

AdpA, a central transcriptional regulator in the A-factor regulatory cascade that leads to morphological development and secondary metabolism in Streptomyces griseus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

RelA protein is involved in induction of genetic competence in certain Bacillus subtilis strains by moderating the level of intracellular GTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Metabolic initiation of differentiation and secondary metabolism by Streptomyces griseus: significance of the stringent response (ppGpp) and GTP content in relation to A factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

CodY is required for nutritional repression of Bacillus subtilis genetic competence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Insight into the polar reactivity of the onium chalcogen analogues of S-adenosyl-L-methionine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

A deficiency in S-adenosylmethionine synthetase interrupts assembly of the septal ring in Escherichia coli K-12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

A radically different mechanism for S-adenosylmethionine-dependent methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Studies on the role of the metK gene product of Escherichia coli K-12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Cloning and characterization of the metE gene encoding S-adenosylmethionine synthetase from Bacillus subtilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Epigenetic phase variation of the pap operon in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Quorum Sensing in Bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Salmonella typhimurium recognizes a chemically distinct form of the bacterial quorum-sensing signal AI-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Autoinducer 2 controls biofilm formation in Escherichia coli through a novel motility quorum-sensing regulator (MqsR, B3022)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Rifampicin-resistance, rpoB polymorphism and RNA polymerase genetic engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Phenotypes and gene expression profiles of Saccharopolyspora erythraea rifampicin-resistant (rif) mutants affected in erythromycin production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Antimicrobial drug resistance affects broad changes in metabolomic phenotype in addition to secondary metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

New horizons for (p)ppGpp in bacterial and plant physiology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Genetic factors that influence moenomycin production in streptomycetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

The magic spot: a ppGpp binding site on E. coli RNA polymerase responsible for regulation of transcription initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

The Mechanism of E. coli RNA Polymerase Regulation by ppGpp Is Suggested by the Structure of their Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

An alternative strategy for bacterial ribosome synthesis: Bacillus subtilis rRNA transcription regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Physiological analysis of the stringent response elicited in an extreme thermophilic bacterium, Thermus thermophilus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Direct regulation of GTP homeostasis by (p)ppGpp: a critical component of viability and stress resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

GTP dysregulation in Bacillus subtilis cells lacking (p)ppGpp results in phenotypic amino acid auxotrophy and failure to adapt to nutrient downshift and regulate biosynthesis genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Activation of dormant bacterial genes by Nonomuraea sp. strain ATCC 39727 mutant-type RNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Natural merodiploidy involving duplicated rpoB alleles affects secondary metabolism in a producer actinomycete.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Characterization of representative rpoB gene mutations leading to a significant change in toyocamycin production of Streptomyces diastatochromogenes 1628.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Overexpression of ribosome recycling factor is responsible for improvement of nucleotide antibiotic-toyocamycin in Streptomyces diastatochromogenes 1628.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Activation and enhancement of Fredericamycin A production in deepsea-derived Streptomyces somaliensis SCSIO ZH66 by using ribosome engineering and response surface methodology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Improved antibiotic production and silent gene activation in Streptomyces diastatochromogenes by ribosome engineering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Production of xylanase by an alkaline-tolerant marine-derived Streptomyces viridochromogenes strain and improvement by ribosome engineering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Heterologous expression of a plant RelA-SpoT homologue results in increased stress tolerance in Saccharomyces cerevisiae by accumulation of the bacterial alarmone ppGpp

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Identification of the bacterial alarmone guanosine 5'-diphosphate 3'-diphosphate (ppGpp) in plants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Arabidopsis RelA/SpoT homologs implicate (p)ppGpp in plant signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Inducible expression, enzymatic activity, and origin of higher plant homologues of bacterial RelA/SpoT stress proteins in Nicotiana tabacum

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

Overexpression of RelA/SpoT homologs, PpRSH2a and PpRSH2b, induces the growth suppression of the moss Physcomitrella patens

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1 reference

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Spontaneous and induced mutations to rifampicin, streptomycin and spectinomycin resistances in actinomycetes: mutagenic mechanisms and applications for strain improvement

21 January 2018

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Antibiotic overproduction by rpsL and rsmG mutants of various actinomycetes

21 January 2018

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Development of antibiotic-overproducing strains by site-directed mutagenesis of the rpsL gene in Streptomyces lividans

21 January 2018

1 reference

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Inactivation of KsgA, a 16S rRNA methyltransferase, causes vigorous emergence of mutants with high-level kasugamycin resistance

21 January 2018

1 reference

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A novel insertion mutation in Streptomyces coelicolor ribosomal S12 protein results in paromomycin resistance and antibiotic overproduction.

21 January 2018

1 reference

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Development of a Genetic System for Combinatorial Biosynthesis of Lipopeptides in Streptomyces fradiae and Heterologous Expression of the A54145 Biosynthesis Gene Cluster

21 January 2018

1 reference

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Effects of Escherichia coli ribosomal protein S12 mutations on cell-free protein synthesis.

21 January 2018

1 reference

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Mutations in rpsL that confer streptomycin resistance show pleiotropic effects on virulence and the production of a carbapenem antibiotic in Erwinia carotovora

21 January 2018

1 reference

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Production improvement of antifungal, antitrypanosomal nucleoside sinefungin by rpoB mutation and optimization of resting cell system of Streptomyces incarnatus NRRL 8089.

21 January 2018

1 reference

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Methylbenzene-Containing Polyketides from a Streptomyces that Spontaneously Acquired Rifampicin Resistance: Structural Elucidation and Biosynthesis.

21 January 2018

1 reference

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A novel method for improving Streptomyces coelicolor A3(2) for production of actinorhodin by introduction of rpsL (encoding ribosomal protein S12) mutations conferring resistance to streptomycin

21 January 2018

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12 December 2020

[Screening of Clostridium strains through ribosome engineering for improved butanol production]

1 reference

12 December 2020

The regulator of streptomycin gene expression, StrR, of Streptomyces griseus is a DNA binding activator protein with multiple recognition sites

1 reference

12 December 2020

The rare earth, scandium, causes antibiotic overproduction in Streptomyces spp

1 reference

12 December 2020

Improved ethanol tolerance and ethanol production from glycerol in a streptomycin-resistant Klebsiella variicola mutant obtained by ribosome engineering

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12 December 2020

Development of a rifampicin-resistant Bacillus subtilis strain for natto-fermentation showing enhanced exoenzyme production

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12 December 2020

Bacterial DNA methylation: a cell cycle regulator?

1 reference

12 December 2020

The Role of Spontaneous Variants in the Acquisition of Streptomycin Resistance by the Shigellae

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12 December 2020

Genome shuffling of Clostridium acetobutylicum CICC 8012 for improved production of acetone-butanol-ethanol (ABE)

1 reference

12 December 2020

Development of the ability to produce secondary metabolites in Streptomyces through the acquisition of erythromycin resistance

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12 December 2020

Genome shuffling of Streptomyces viridochromogenes for improved production of avilamycin

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12 December 2020

Epigenetic remodeling of the fungal secondary metabolome

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12 December 2020

Activation of secondary metabolite-biosynthetic gene clusters by generating rsmG mutations in Streptomyces griseus

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12 December 2020

Initiation of Bacillus subtilis sporulation by the stringent response to partial amino acid deprivation

1 reference

12 December 2020

E. coli ribosomes with a C912 to U base change in the 16S rRNA are streptomycin resistant

1 reference

12 December 2020

Mycolic acid-containing bacteria activate heterologous secondary metabolite expression in Streptomyces lividans

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12 December 2020

Improvement of A21978C production in Streptomyces roseosporus by reporter-guided rpsL mutation selection

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12 December 2020

A functional pseudoknot in 16S ribosomal RNA

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12 December 2020

Activation of fungal silent gene clusters: a new avenue to drug discovery.

1 reference

12 December 2020

A cryptic antibiotic triggered by monensin

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12 December 2020

A magic bullet for antibiotic discovery

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12 December 2020

Acquisition of certain streptomycin-resistant (str) mutations enhances antibiotic production in bacteria

1 reference

12 December 2020

Construction of a new bacterial artificial chromosome (BAC) vector for cloning of large DNA fragments and heterologous expression in Streptomyces

1 reference

12 December 2020

Stationary-phase production of the antibiotic actinorhodin in Streptomyces coelicolor A3(2) is transcriptionally regulated

1 reference

12 December 2020

Synthetic biology advances for pharmaceutical production

1 reference

12 December 2020

Promomycin, a polyether promoting antibiotic production in Streptomyces spp.

1 reference

12 December 2020

Impact of interspecific interactions on antimicrobial activity among soil bacteria

1 reference

12 December 2020

S-Adenosylmethionine and methylation

2 references

12 December 2020

https://api.crossref.org/works/10.1038%2FJA.2016.82

7 January 2021

inferred from DOI database lookup

The 5' proximal helix of 16S rRNA is involved in the binding of streptomycin to the ribosome

1 reference

12 December 2020

Inducing secondary metabolite production by the soil-dwelling fungus Aspergillus terreus through bacterial co-culture

1 reference

https://api.crossref.org/works/10.1038%2FJA.2016.82

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/JA.2016.82

1 reference

Dimensions Publication ID

7 September 2017

1050793846

0 references

1 reference