(Q38887432)

7 September 2017

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title

Targeting ceramide metabolism in obesity (English)

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7 September 2017

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Hanin Aburasayn

1

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7 September 2017

Rami Al Batran

series ordinal

2

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7 September 2017

John R Ussher

series ordinal

3

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7 September 2017

publication date

5 July 2016

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American Journal of Physiology - Endocrinology and Metabolism

7 September 2017

published in

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7 September 2017

volume

311

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7 September 2017

issue

2

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7 September 2017

page(s)

E423-35

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Ceramide content is increased in skeletal muscle from obese insulin-resistant humans

7 September 2017

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21 January 2018

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Ceramide-enriched membrane domains

21 January 2018

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Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance

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Ceramide kinase: the first decade

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Implication of sphingomyelin/ceramide molar ratio on the biological activity of sphingomyelinase

21 January 2018

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Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice

21 January 2018

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Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis

21 January 2018

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Ceramides - Lipotoxic Inducers of Metabolic Disorders

21 January 2018

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Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling

21 January 2018

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A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids

21 January 2018

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A ceramide-centric view of insulin resistance

21 January 2018

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Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure

21 January 2018

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Inhibition of sphingomyelin hydrolysis: targeting the lipid mediator ceramide as a key regulator of cellular fate

21 January 2018

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Insulin resistance is associated with higher intramyocellular triglycerides in type I but not type II myocytes concomitant with higher ceramide content

21 January 2018

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Role of intramyocelluar lipids in human health

21 January 2018

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Acid sphingomyelinase is required for lipid Raft TLR4 complex formation

21 January 2018

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Cis-9, trans-11 and trans-10, cis-12 CLA mixture does not change body composition, induces insulin resistance and increases serum HDL cholesterol level in rats.

21 January 2018

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Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: evidence for the role of sphingosine and sphinganine in hepatic VLDL-apoB100 overproduction.

21 January 2018

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Doxorubicin induces slow ceramide accumulation and late apoptosis in cultured adult rat ventricular myocytes

21 January 2018

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Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited

21 January 2018

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Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide.

21 January 2018

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Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes

21 January 2018

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Docosahexaenoic acid prevents trans-10, cis-12-conjugated linoleic acid-induced nonalcoholic fatty liver disease in mice by altering expression of hepatic genes regulating fatty acid synthesis and oxidation

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Accumulation of ceramide in slow-twitch muscle contributes to the development of insulin resistance in the obese JCR:LA-cp rat.

21 January 2018

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Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010

21 January 2018

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Obesity and Diabetes: The Increased Risk of Cancer and Cancer-Related Mortality

21 January 2018

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Variations among cell lines in the synthesis of sphingolipids in de novo and recycling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Ceramide and insulin resistance: how should the issue be approached?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Sustained Action of Ceramide on the Insulin Signaling Pathway in Muscle Cells: IMPLICATION OF THE DOUBLE-STRANDED RNA-ACTIVATED PROTEIN KINASE

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Targeting of PKCzeta and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance

21 January 2018

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Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice

21 January 2018

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An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice

21 January 2018

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Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

21 January 2018

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Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin.

21 January 2018

1 reference

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Ceramide inhibits insulin-stimulated Akt phosphorylation through activation of Rheb/mTORC1/S6K signaling in skeletal muscle

21 January 2018

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Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway

21 January 2018

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Targeting fatty acid and carbohydrate oxidation--a novel therapeutic intervention in the ischemic and failing heart.

21 January 2018

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Modulation of the expression of sphingosine 1-phosphate 2 receptors regulates the differentiation of pre-adipocytes

21 January 2018

1 reference

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Ceramide as a mediator of non-alcoholic Fatty liver disease and associated atherosclerosis

21 January 2018

1 reference

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PKB/Akt inhibits ceramide-induced apoptosis in neuroblastoma cells by blocking apoptosis-inducing factor (AIF) translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

The sphingolipid salvage pathway in ceramide metabolism and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Inhibition of ceramide de novo synthesis reduces liver lipid accumulation in rats with nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Ganglioside GM3 as a gatekeeper of obesity-associated insulin resistance: Evidence and mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

A review of ceramide analogs as potential anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Lipid mediators of insulin resistance: ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Hepatic ceramide may mediate brain insulin resistance and neurodegeneration in type 2 diabetes and non-alcoholic steatohepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Plasma dihydroceramide species associate with waist circumference in Mexican American families

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Palmitate-induced impairments of β-cell function are linked with generation of specific ceramide species via acylation of sphingosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

The endoplasmic reticulum-mitochondria connection: one touch, multiple functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Novel apoptosis inducing agents in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Sphingosine-1-phosphate inhibits the adipogenic differentiation of 3T3-L1 preadipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Ceramide and apoptosis: exploring the enigmatic connections between sphingolipid metabolism and programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Lipid-induced mitochondrial stress and insulin action in muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Evaluation of collagen in atherosclerotic plaques: the use of two coherent laser-based imaging methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Cardiomyocyte mitochondrial respiration is reduced by receptor for advanced glycation end-product signaling in a ceramide-dependent manner.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Lactosylceramide contributes to mitochondrial dysfunction in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Serine palmitoyltransferase inhibitor myriocin induces the regression of atherosclerotic plaques in hyperlipidemic ApoE-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Ceramide is a cardiotoxin in lipotoxic cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Ceramide kinase promotes tumor cell survival and mammary tumor recurrence

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Stress-induced apoptosis and the sphingomyelin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

N-3PUFA differentially modulate palmitate-induced lipotoxicity through alterations of its metabolism in C2C12 muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Mechanisms for insulin resistance: common threads and missing links

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

The phospholipase C inhibitor U73122 attenuates trans-10, cis-12 conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Partial purification and characterization of sphingosine N-acyltransferase (ceramide synthase) from bovine liver mitochondrion-rich fraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Mitochondrial fission mediates ceramide-induced metabolic disruption in skeletal muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Apoptosis as a novel target for cancer chemoprevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Myocardial AKT: the omnipresent nexus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Circulating tumor necrosis factor alpha concentrations are higher in abdominal versus peripheral obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

The role of cardiac lipotoxicity in the pathogenesis of diabetic cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Inhibition of serine palmitoyl transferase I reduces cardiac ceramide levels and increases glycolysis rates following diet-induced insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Plasma membrane production of ceramide from ganglioside GM3 in human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

TLR4 at the Crossroads of Nutrients, Gut Microbiota, and Metabolic Inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Chronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Regulation of plasma ceramide levels with fatty acid oversupply: evidence that the liver detects and secretes de novo synthesised ceramide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Regulation of the intrinsic apoptosis pathway by reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Enhanced insulin sensitivity in mice lacking ganglioside GM3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Adiponectin, driver or passenger on the road to insulin sensitivity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

The acid sphingomyelinase/ceramide pathway: biomedical significance and mechanisms of regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Lipotoxicity in obesity and diabetes-related cardiac dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Ceramide generated by acidic sphingomyelinase contributes to tumor necrosis factor-α-mediated apoptosis in human colon HT-29 cells through glycosphingolipids formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.00133.2016

10.1152/AJPENDO.00133.2016

21 January 2018

Identifiers

DOI

1 reference

7 September 2017

1 reference