(Q38922557)

7 September 2017

Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer (English)

1 reference

protein-protein interaction

7 September 2017

1 reference

Diego Acosta-Alvear

4

0 references

Martin Kampmann

object named as

Martin Kampmann

5

0 references

Jonathan Weissman

12

object named as

Jonathan S Weissman

1 reference

7 September 2017

11

Peter Walter

1 reference

7 September 2017

Xiaokai Li

1

1 reference

7 September 2017

Teresa Colvin

2

1 reference

7 September 2017

Jennifer N Rauch

3

1 reference

7 September 2017

Bryan Dunyak

6

1 reference

7 September 2017

Byron Hann

7

1 reference

7 September 2017

Blake T Aftab

8

1 reference

7 September 2017

Megan Murnane

9

1 reference

7 September 2017

Min Cho

10

1 reference

7 September 2017

Michael Y Sherman

13

1 reference

7 September 2017

Jason E Gestwicki

14

1 reference

7 September 2017

6 January 2015

1 reference

Molecular Cancer Therapeutics

7 September 2017

1 reference

7 September 2017

14

1 reference

7 September 2017

3

1 reference

7 September 2017

642-648

1 reference

Hsp70-Bag3 interactions regulate cancer-related signaling networks

7 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

Targeting protein-protein interactions as an anticancer strategy

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

Hsp70 protein complexes as drug targets

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

Fine-tuning multiprotein complexes using small molecules

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

Molecular and cellular effects of NEDD8-activating enzyme inhibition in myeloma.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

Molecular chaperones in protein folding and proteostasis

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

BAG3: a multifaceted protein that regulates major cell pathways

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

Heat shock protein 70 (hsp70) as an emerging drug target.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

Inhibition of the p53-MDM2 interaction: targeting a protein-protein interface.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factors

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

A small molecule inhibitor of inducible heat shock protein 70.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4456214

Phase I trial of the selective mitochondrial toxin MKT 077 in chemo-resistant solid tumours

22 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25564440

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Pharmacokinetic analysis and antitumor efficacy of MKT-077, a novel antitumor agent

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25564440

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Bag3 gene expression is regulated by heat shock factor 1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25564440

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/1535-7163.MCT-14-0650

1 reference

7 September 2017

1 reference

7 September 2017

PubMed publication ID

25564440

1 reference